Congenital sensory neuropathy with anhidrosis.
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Child↗
Biomedical subjects
L C Thakur
Publications and source records attributed to L C Thakur.
Influence of type I and type II diabetes mellitus on phenytoin steady-state levels.
Phenytoin kinetics was studied in male type I and type II diabetic patients, ten in each group. Age and sex matched epileptic patients receiving phenytoin alone served as control groups. Steady-state concentration of phenytoin was significantly lower in both types of diabetics compared to respective controls. The Vmax and Vmax/Km of phenytoin were significantly increased in type I diabetics. The Vmax was unaltered in type II diabetics but the Vmax/Km was higher in them. Protein binding of the drug was decreased in both groups. It is concluded that phenytoin kinetics is increased in both types of diabetics which may be responsible for the lower steady-state concentration of the drug.
Adult↗
Cryptogenic chorea.
A total of 40 cases of cryptogenic chorea were studied over a period of 4 years in JIPMER Hospital which serves the population of Pondicherry and adjoining regions of South India. Analysis of our cases showed the highest incidence for the 10-15 year age group with no sex predilection. Arthralgia and non-specific fever preceded the onset of chorea in most patients. The majority had generalized chorea of variable severity. Laboratory evidence of rheumatic fever was absent in all cases. The socioeconomic, environmental and cultural factors contributing to persistently high rate of infections together with the absence of evidence of a rheumatic process indicate a non-rheumatic aetiology.
Adolescent↗
Childhood neurocysticercosis in south India.
A total of 21 cases of childhood neurocysticercosis seen over five years (1985-89) at JIPMER hospital Pondicherry, are reported. Nine of these patients were males and twelve females. Their age ranged between 5 to 15 years. The presenting features were convulsive seizures (14), features of raised intracranial pressure (6) and meningoencephalitis syndrome (1). Diagnosis of neurocysticercosis was based on positive CSF serological tests (11), CT morphology (11), brain biopsy (1) and autopsy (1). Praziquantel therapy was given in 4 cases, 3 of them showed remarkable improvement in neurological status and one died of acute reaction.
Adolescent↗