Earl D. Osborne (1895-1960).
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Biomedical subjects
Publications and source records attributed to L C Parish.
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A 29-year-old woman developed a pulsating, fixed drug eruption following a year's course of both oral and parenteral administration of tetracycline for pharyngitis. Patch testing of tetracycline powder under occlusion at the site confirmed the diagnosis.
Eighty-seven basal cell carcinomas were treated by surgical excision. Sites of removal were allowed to heal by secondary intention. Advantages of this method include histologic monitoring of the adequacy of incision, a less formidable surgical procedure, and a cosmetically acceptable scar.
A 27-year-old black man with Crohn's disease and nodules on the legs is described. Such nodules constitute one of three types of cutaneous manifestations which have a histological picture of a non-caseating granuloma. The two other varieties of skin lesions described are: that resulting from a direct spread from the gastrointestinal tract, and that resulting from spread over contiguous skin.
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One hundred and twenty-one patients were treated in a double-blind fashion with .025% betamethasone benzoate gel and 0.1% betamethasone valerate cream. Results were not statistically significant, although 14 of 16 patients with psoriasis showed excellent results with betamethasone benzoate gel, as opposed to six of 14 patients given betamethasone valerate cream.
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