Search PubMed⌕ Search

Biomedical subjects

L C Parish

Publications and source records attributed to L C Parish.

At least 37 records · Page 2Linked to original sources
PubMed1995

Scabies.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗
PubMed1995

MaltaDerm '94.

Explore the source record for details and available documents.

Dermatology↗
PubMed1995

Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris.

BACKGROUND: Systemic and topical antimicrobials are effective in the treatment of inflammatory acne vulgaris; however, widespread use of these agents is becoming increasingly associated with the emergence of resistant pathogens raising concerns about microorganism resistance and highlighting the need for alternative nonantimicrobial agents for the treatment of acne. Nicotinamide gel provides potent antiinflammatory activity without the risk of inducing bacterial resistance. METHODS: In our double-blind investigation, the safety and efficacy of topically applied 4% nicotinamide gel was compared to 1% clindamycin gel for the treatment of moderate inflammatory acne vulgaris. Seventy-six patients were randomly assigned to apply either 4% nicotinamide gel (n = 38) or 1% clindamycin gel (n = 38) twice daily for 8 weeks. Efficacy was evaluated at 4 and 8 weeks using a Physician's Global Evaluation, Acne Lesion Counts, and an Acne Severity Rating. RESULTS: After 8 weeks, both treatments produced comparable (P = 0.19) beneficial results in the Physician's Global Evaluation of Inflammatory Acne; 82% of the patients treated with nicotinamide gel and 68% treated with clindamycin gel were improved. Both treatments produced statistically similar reductions in acne lesions (papules/pustules; -60%, nicotinamide vs. -43%, clindamycin, P = 0.168), and acne severity (-52% nicotinamide group vs. -38% clindamycin group, P = 0.161). CONCLUSIONS: These data demonstrate that 4% nicotinamide gel is of comparable efficacy to 1% clindamycin gel in the treatment of acne vulgaris. Because topical clindamycin, like other antimicrobials, is associated with emergence of resistant microorganisms, nicotinamide gel is a desirable alternative treatment for acne vulgaris.

Acne Vulgaris↗
PubMed1994

Ectoparasites as sexually transmitted diseases.

Although Sarcoptes scabii and Phthirus pubis infestations in humans are not always associated with the presence of other sexually transmitted diseases, usually they are. Therefore, patients presenting with scabies or P. pubis should be routinely tested for various sexually transmitted diseases. These very uncomfortable infestations are easily curable with proper therapy. Lindane 1% preparations effectively exterminate both vermin. We have not seen any resistant strains. Especially with P. pubis, all household contacts should be treated to avoid reinfestation.

Animals↗
PubMed1993

Systemic antimicrobial therapy for skin and skin structure infections: comparison of fleroxacin and ceftazidime.

Intravenous fleroxacin, 400 mg once a day, was compared with ceftazidime, 0.5-2 g three times a day or 1-2 g twice a day, for the treatment of skin and skin structure infections. Duration of treatment was 4-21 days. The study was a multicenter, unblinded comparison. Of the 316 patients enrolled, 212 were randomized to treatment with fleroxacin and 104 to ceftazidime (2:1 ratio); 92 fleroxacin-treated patients and 50 ceftazidime-treated patients were included in the standard analysis of efficacy. The most common diagnoses were wound infections and cellulitis, which affected 36% and 30% of the fleroxacin group, and 24% and 24% of the ceftazidime group, respectively. In the fleroxacin group, 82% of the infecting organisms were eradicated, and in the ceftazidime group, 79%. The overall rates of bacteriologic cure, by infection, were 79% for the fleroxacin group and 74% for the ceftazidime group, and those for clinical cure were 82% and 73%, respectively. It could not be concluded with 95% confidence that the two regimens resulted in equivalent cure rates because the range of between-group differences was outside the stipulated limits of +/- 15%. The percentage of patients with one or more adverse events was approximately twice as high (17% vs. 9%) in the fleroxacin group than in the ceftazidime group. The most frequent event in both groups was nausea. In this study, intravenous therapy with fleroxacin or ceftazidime produced similar bacteriologic and clinical cure rates, but the statistical requirements permitting a conclusion of equivalence at protocol levels were not met.

Adolescent↗
PubMed1993

Clarithromycin in the treatment of skin and skin structure infections: two multicenter clinical studies. Clarithromycin Study Group.

BACKGROUND: Clarithromycin is a new macrolide analog of erythromycin with activity against a number of dermatologic pathogens. METHODS: The efficacy and safety of clarithromycin, 250 mg bid, were compared with those of reference drugs, cefadroxil and erythromycin, in two multicenter studies: (1) a randomized, double-blind 45-center study, in which clarithromycin or cefadroxil 500 mg bid was given for 5-14 days; and (2) a single-blind 31-center study, in which clarithromycin or erythromycin, 250 mg qid, was given for < or = 14 days. RESULTS: In the first study, efficacy and safety were evaluated in 299 and 538 patients, respectively. In the second study, the numbers were 141 and 261 patients, respectively. Overall, clarithromycin was as effective and safe as cefadroxil and erythromycin. CONCLUSIONS: Clarithromycin provides an alternative therapy to cefadroxil and erythromycin for skin and skin structure infections, especially in beta-lactam allergic patients.

Cefadroxil↗
PubMed1993

Zoonoses of dermatological interest.

The zoonoses are those diseases transmitted from animals to humans. Although commonly thought to be infectious in origin such as scabies or dermatophytosis, inflammatory processes may also be zoonotic. Contact dermatitis may result from allergens being carried from animals to humans. Although the scabies mite is somewhat species specific, various mites sometimes have the opportunity of producing skin disease on man (ie, canine scabies, porcine scabies, and feline scabies [notoedric mange]); cheyletiellosis is caused by a similar mite, often found in rabbits. The index case of superficial fungal infections may be the household pet, whereas the cause of flea bite dermatitis (papular urticaria) may be the lack of an animal, resulting in the flea choosing a human for feeding. Understanding zoonotic skin diseases will improve the clinician's diagnostic skills. Both the human and animal patient will then receive more effective treatment in a quicker fashion.

Animals↗
PubMed1992

Truncal morbilliform eruption due to nifedipine.

A fifty-year-old white woman noted a morbilliform eruption that involved her trunk, arms, and legs but spared her face, following oral administration of nifedipine, a calcium channel blocker. Other dermatologic reactions to nifedipine have included edema with erythema, erythromelalgia, exfoliative erythroderma, leukocytoclastic vasculitis, purpura, and fixed drug reactions.

Drug Eruptions↗
PubMed1991

Systemic management of cutaneous bacterial infections.

Cutaneous bacterial infections can be treated by a variety of modalities, although systemic antimicrobial agents usually provide the most efficacious and efficient means for treatment. Oral administration allows outpatient management, thus decreasing the overall cost of treatment. Although gram-negative organisms are increasingly implicated in dermatologic infections, the bacteria that are commonly found in skin infections include group A beta-hemolytic Streptococcus and Staphylococcus aureus, which cause many types of pyoderma or impetigo. Not every patient exhibits the common signs of bacterial skin infection, which can include redness, crusting, induration, increased local temperature, serous exudate, a purulent discharge, pustules, bullae, or a foul-smelling odor, as well as such symptoms as malaise, pain, and tenderness. Bacterial confirmation may also be difficult. Beta-lactam antibiotics, tetracycline, and erythromycin have proven useful in this setting; however, increasing resistance is problematic. The management of bacterial infections of the skin and skin structure has been expanded during the past decade with the introduction of the new fluoroquinolones--agents with a wide spectrum of antimicrobial activity and good pharmacokinetic characteristics. While the clinical efficacy of each agent must be considered in the light of risk of adverse events and potential drug interactions, ciprofloxacin, enoxacin, ofloxacin, and temafloxacin appear to be most useful for cutaneous bacterial infections.

Anti-Infective Agents↗