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Biomedical subjects

L C Mark

Publications and source records attributed to L C Mark.

39 records · Page 3Linked to original sources

Determination of optically active thiopental, thiamylal, and their metabolites in human urine.

Methods involving solvent extraction and gas-liquid chromatography have been developed for quantitative determination of certain thiobarbiturates and their major metabolites in urine. The structures of the metabolites identified were confirmed by the use of gas chromatography/mass spectrometry and 13C-nuclear magnetic resonance spectroscopy. The present analytic methods were applied to the quantitative determination of (R)-(+)- and (S)-(-)-thiopental as well as (R)-(+)- and (S)-(-)-thiamylal and their major metabolites excreted in human urine. Minor metabolites were isolated and identified.

Chromatography, Gas↗