Search PubMed⌕ Search

Biomedical subjects

L C Harris

Publications and source records attributed to L C Harris.

At least 55 records · Page 3Linked to original sources

Contribution of social and developmental factors to lead exposure during the first year of life.

The social and developmental correlates of early lead exposure were explored in an interim analysis of data from an ongoing longitudinal investigation in Cincinnati. Regardless of the apparent net availability of lead in the infant's physical environment, parental behavior was still significantly associated with infant blood lead levels. However, this was only the case after infants in the study reached 6 months of age and beyond when prewalking progression and early walking made parental management all the more critical. Future lead screening and abatement programs should include supports for the caretaker-child relationship.

Child Development↗

Neuroheptapeptide influence on attention and memory in man.

Twenty normal, male volunteers were administered a subcutaneous injection of either ACTH/MSH 4-10 or diluent and two weeks later received the alternate injection in a complete crossover, double-blind design with order balanced. Subjects were given a battery of psychological tests, including a continuous performance task (CPT), following each injection. Visual evoked responses were recorded during the CPT. Resting, eyes-closed EEGs were also obtained. ACTH/MSH 4-10 improved attention and in so doing improved visual-motor learning and visual, but not verbal, memory, EEG data were consistant with activation of the diffuse thalamic projection system.

Adrenocorticotropic Hormone↗

Clinical experience with an oral anticoagulant in children.

Nineteen cardiac patients were given warfarin sodium to prevent thrombosis and embolism. Empirical dosage resulted in long hospital stays to obtain a stable therapeutic prothrombin time. Using a dosage of 0 therefore 5-0 therefore 7 mg/kg, therapeutic levels were achieved in a much shorter time. When prothrombin time was excessive, it was successfully reduced with vitamin K or plasma. A haematoma in one case and haematuria in another were easily controlled. Warfarin sodium appears to be appropriate and effective for children requiring anticoagulants within the above dosage limits and with meticulous follow-up.

Administration, Oral↗