Biomedical subjects
Publications and source records attributed to L C Fuith.
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Interferons are known to modulate several cellular functions by the induction of different proteins. In our study a gamma-interferon-mediated presentation of one of the most important ovarian tumor markers (CA-125) on the cell surface was demonstrated using two ovarian carcinoma cell lines in vitro (HTB-77 and SKOV-3). This induction was found to be dependent on an intact protein biosynthesis. The gamma-interferon effect reached a maximum on the third day of treatment. Under such conditions the CA-125 concentration was increased intracellularly, on the cell surface, and in the supernatant culture medium. The surface antigen was shed rapidly with a half-life of 1 day. The addition of dexamethasone to gamma-interferon treated HTB-77 cells improved CA-125 expression synergistically. HLA-DR and CA-125 expression was found to be regulated by interferons in different ways. The demonstration of CA-125 expression provides an important insight into the potential regulatory mechanism governing this tumor marker. Since interferons are naturally occurring substances as well as therapeutically administered agents, it seems necessary to pay attention to possible tumor marker modulation.
The employment of tumour markers in gynaecology has gained increasing importance in recent times. Beta HCG for chorionic carcinoma and alpha 1 fetoprotein for germ cell tumours are an essential part of postoperative surveillance. Initial analyses of the amylase isoenzymes are available. CEA, TPA, and CA 125 are recognized as established tumour markers. Very promising results have been obtained using SCC in patients with cervical carcinoma. Neopterin, a marker for cell-mediated immunity, provides good prognostic information.
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Within a 3-years period the presence of nosocomial bacteriaemias was analyzed retrospectively among 13.878 hospitalized patients. The incidence was 0.050%. Antibiotic prophylaxis and the operative technique play an important role in achieving a low incidence of morbidity due to infection. The management of a severe infection includes antibiotic therapy according to culture sensitivity and intensive care.
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CA 125 serum concentrations drawn immediately following delivery exceeded 35 U/ml in all cases (median 276 U/ml). One week post partum elevations of CA 125 were still found, but the median level decreased to 45 U/ml. Six weeks after parturition no positivity was detected in the serum (median 12 U/ml). Considerable CA 125 levels were present in the human milk 1 week after delivery (median 208 U/ml). CA 125 was still found in the milk after 6 weeks (median 153 U/ml). We conclude that positive CA 125 concentrations in the serum after parturition derive from an antigen transfer to the maternal circulation during the placental separation. Furthermore, CA 125 seems to be synthesized by the lactating breast.
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