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Biomedical subjects

L C Chen

Publications and source records attributed to L C Chen.

222 records · Page 13Linked to original sources
PubMedDate not supplied

Modulation of epidermal growth factor receptors by gamma interferon in a breast cancer cell line.

Interferons (IFNs) may inhibit cell growth via their interaction with growth factors and their receptors. We examined the ability of IFN to modulate Epidermal Growth Factor (EGF) receptor binding in a human breast carcinoma cell line, MDA 468. Gamma interferon and alpha interferon inhibited growth of MDA 468 cells in a dose and time-dependent manner. IFN-gamma and Epidermal Growth Factor (EGF), a known inhibitor of MDA 468 growth, inhibited growth in an additive fashion. Growth inhibition by gamma but not alpha interferon was associated with a decrease in the number of EGF receptors (EGFRs) after 5 days. Scatchard analysis of receptor binding data revealed that gamma but not alpha interferon reduced the number of available EGF receptor binding sites without any change in the affinity of the receptor. IFN significantly affected EGF receptor expression, and the decrease in receptor expression was associated with growth inhibition.

Breast Neoplasms↗
PubMedDate not supplied

Serum osteocalcin levels of normal children in Taiwan.

Osteocalcin is mainly secreted by osteoblasts, and then diffuses into blood which can be detected by several experimental methods. This study determined the osteocalcin level by solid phase fluorescent immunosorbent assay (Pharmacia CAP; Sweden), a well-established and accurate laboratory method for determining the minor concentration of substances in blood. A total of 332 healthy children were enrolled in the study, including 176 boys and 156 girls ranging in age from one to fifteen years. It was concluded that (1) quantitative osteocalcin (OCs) value varies between 30.2 to 41.0 ng/ml; (2) there is an incremental tendency in both sexes until puberty; (3) girls generally have a higher osteocalcin level than boys before mid-puberty (2-12 years old). The differences are statistically significant.

Adolescent↗
PubMedDate not supplied

Pemphigus vulgaris.

Pemphigus vulgaris is an autoimmune vesiculobullous disease of the skin and the mucous membrane. It most commonly involves the population of the fifth and sixth decades, and is extremely rare in children. We report a case of this disease in a 13-year-old boy, who was documented to have pemphigus vulgaris with historical, histopathological, and immunological criterion. He received corticosteroid and immunosuppressive drugs and a good response was achieved. We concluded that pemphigus vulgaris is a rare disease in children, but it should be kept in mind as a differential diagnosis of oral ulceration along with skin manifestation in children.

Adolescent↗