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Biomedical subjects

L Butturini

Publications and source records attributed to L Butturini.

35 records · Page 2Linked to original sources
PubMed1985

[The hormonal response to hypercalcemic stimulation: the difference between male and female young people].

The aim of our study was to evaluate the pattern of response of thyroid Calcitonin (CT) secretory cells in young healthy people after specific stimulation. For this purpose, test of 60'' i.v. calcium infusion in a dose of 4 mg/Kg lean body mass was employed. Blood samples were taken at times-5', 0', 2', 5', 10', 15', and 30' after the infusion, to determine total Calcium (Ca), ionized calcium (Ca++) and CT concentrations. As a result, plasma CT increased significantly (f = 24.51, p less than 0.000001) in both sexes, while males showed stimulated CT values about double than the female ones: the difference was statistically significant throughout the test. In males too, we observed a strong and significant (r = 0.92, p less than 0.01) correlation between ionized calcium increases and CT responses. This correlation was found neither in males as regards total calcium, nor in females. In conclusion, our data confirm the higher CT secretion in males, indicating also a more constant pattern of response in this sex. Eventually, ionized calcium proves to be the real effective provocative stimulus for CT secretion.

Adult↗
PubMedDate not supplied

Whole blood filterability in elderly obese women.

In order to establish whether obesity alters whole blood filterability, the corrected whole blood filtration (VRBC) was measured in 54 elderly obese women (mean age +/- SE = 67 +/- 2 years) without (n = 15) or with associated cardiovascular risk factors such as impaired glucose tolerance (IGT) (n = 11), non-insulin dependent diabetes mellitus (NIDDM) (n = 14) or hypertension (n = 14). Twenty-two age matched women with normal body weight participated as controls. VRBC values were similar in normal controls and obese women with normal glucose tolerance (NGT), whereas they were significantly lower in obese subjects with hypertension, NIDDM or IGT. When subjects with normal and impaired glucose tolerance were combined, a significant negative correlation was found between glucose incretory areas during OGTT and VRBC values. These data demonstrate that obesity per se does not alter whole blood filterability; furthermore, our results indicate that this modification is a precocious and sensitive index of altered glucose metabolism.

Aged↗
PubMedDate not supplied

[Sequential calcitriol-calcitonin in the therapy of osteoporosis].

Different therapeutic regimens have been proposed by Authors in the treatment of involutional (and particularly postmenopausal) osteoporosis. Following the up to date concepts on bone remodelling, an ADFR (Activate, Depress, Free, Repeat) trial was performed in 20 females affected by involutional osteoporosis. They were treated with Calcitriol 2 mcg/d for 7 days, followed by a 21 days period of 100 U/d Salmon Calcitonin + 1 g/d Calcitonin, followed by a 2-month period of Calcium alone. The cycles were repeated for 1 year and the results of densitometric examinations (radial mineral content evaluated by single photon absorptiometer, and vertebral mineral content evaluated by dual photon absorptiometer) and of biochemical markers (Ca++, P, osteocalcin, alkaline phosphatase, hydroxyproline) controlled every 3 months, were compared with those obtained in a group of patients treated only with Salmon Calcitonin and in a group treated with Calcium for 1 year. After two therapeutical cycles radial bone mineral density significantly increased; vertebral bone density also increased but not significantly. The effects were more evident in comparison to calcitonin alone treatment. A significant reduction in serum osteocalcin was documented. At the end of the therapy no further improvement was registered. This suggests that some variations and adaptation of therapeutic strategy are needed to achieve a more important and substantial improvement of bone conditions.

Administration, Oral↗
PubMedDate not supplied

Amikacin-induced liver toxicity: correlations between biochemical indexes and ultrastructural features in an experimental model.

In previous studies, aminoglycosides (AG) as gentamicin (G), dibekacin (D), tobramycin (T), netilmicin (N) and Sysomicin (S) were proved to induce ultrastructural alterations in the liver of experimental animals. The aim of this studies is to investigate the effect of amikacin (AK) on rabbit liver which is commonly used in infections resistant to other AG; this was done studying both the common blood parameters and ultrastructural changes. The study was accomplished in 24 New-Zealand rabbits, twelve received 20 mg/kg AK every 12 hours for 2 weeks. Thereafter the animals were anesthesized and liver slices were obtained for transmission electron microscopy. As results obvious signs of primary and secondary microcholestasis associated to mitochondrial cristae detachment and phospholipid aggregations were noted; this last finding was less marked when compared to previous studies employing other AG. In the AK treated group, blood tests showed a significant increased in only Blood Urea Nitrogen (BUN) and an insignificant rise in AST levels. Our findings are consistent with an AK induced liver toxicity albeit less evident with respect to the other AG.

Amikacin↗
PubMedDate not supplied

[Ultrastructural study of the liver in rabbits treated with diclofenac].

The existence of alterations of common indexes of hepatic function, and the case-reports of acute hepatitis after the use of diclofenac sodium are the rationale for this experimental study, in which 8 rabbits were given 15 mg/kg day of diclofenac, to check ultrastructural modifications with respect to a control group. The analysis showed the typical signs of primary and secondary microcholestasis, indicating the existence of liver distress. This finding, from a clinical standpoint, suggests caution in the administration of this drug, chiefly in the hepatopathic patients.

Animals↗