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Biomedical subjects

L Burd

Publications and source records attributed to L Burd.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Tourette disorder in North Dakota.

This paper describes the symptom profiles of a large group of patients with Gilles de la Tourette disorder (TD). In Part one we report the results of a questionnaire study of patients in North Dakota with TD. The data suggest that TD patients have high rates of academic and social problems. Obsessive-compulsive symptomatology is quite high in this population. This report is unique in that these results are reported using an available data base to allow for pooling of future research in TD patients in other settings. In Part two of this paper we discuss important findings from our clinic population of 130 TD patients.

Adolescent↗
PubMedDate not supplied

Familial pervasive development disorder, Tourette disorder and hyperlexia.

Four children and one adult have been found to have Pervasive Developmental Disorder, Tourette disorder and hyperlexia in North Dakota, a state with a population of 204,161 children ages 0-18. Assuming that these are independent disorders the probability of these three disorders occurring by chance in one child is 3.39 x 10(-12). Two of these individuals are from the same family. This suggests evidence for genetic linkage among these three disorders.

Adult↗
PubMedDate not supplied

A clinical pharmacological approach to treating Tourette syndrome in children and adolescents.

Tourette Syndrome (TS) is a neuropsychiatric movement disorder characterized by the presence of multiple motor and phonic tics. Monoamine neurotransmitter dysfunction has been implicated in the expression of the condition. Standard as well as novel pharmacologic treatments for TS as a sole entity or as a condition co-morbid with attention deficit-hyperactivity disorder (ADHD) and/or obsessive-compulsive disorder (OCD) target these presumed neurotransmitter abnormalities. Choice of a specific medication is also predicated upon an individual patient's symptom profile, a cost-benefit analysis of desired effects versus side effects, and the impact on co-morbid conditions. Maximum involvement of the patient and parent or significant other is encouraged. It is emphasized that pharmacologic treatment is primarily symptomatic, usually not affecting the longer term outcome of specific syndromes per se. The integration of pharmacologic with psychoeducational interventions is encouraged.

Adolescent↗
PubMedDate not supplied

Differential responsiveness to lithium in patients with Tourette disorder.

The current status of the use of lithium in the treatment of tic disorders is reviewed. Areas of pathophysiologic overlap between bipolar and tic symptomatology are explored from the standpoint of shared etiology versus co-morbidity. Data from ten cases of children and adolescents with tic disorders treated with lithium are presented. Five exhibited a positive response to tic and associated symptoms, while five did not. Treatment responders versus nonresponders were compared along a number of parameters including co-morbidity with other syndromes, family history, prior medication history, medication used concurrently with lithium, and medication used subsequent to treatment with lithium. Differences between the two groups are explored.

Child↗
PubMedDate not supplied

Tourette disorder and schizophrenia in children.

In North Dakota children, the prevalence rate for DSM-III schizophrenia is 0.19 per 10,000 for both sexes; for males 0.35 per 10,000 and 0 per 10,000 for females. In this report we utilize case studies to convey the symptomatic courses of the 2 child patients with DSM-III-R defined schizophrenia. Both patients first developed Tourette Disorder (TD) and later developed schizophrenia by DSM-III and by DSM-III-R criteria. Among North Dakota children with TD the prevalence rate of schizophrenia is 8.7% for boys. The ramifications of concordance for the two disorders are explored.

Child↗
PubMedDate not supplied

Tourette disorder and mutational falsetto.

Speech, language and voice disorders associated with Tourette Disorder (TD) are reviewed. Two cases of TD associated with falsetto are presented. The relationship between abnormalities in vocal pitch and tic symptomatology is explored.

Adolescent↗
PubMedDate not supplied

Diagnosis of autism and other pervasive developmental disorders.

Problems in the diagnosis of autism and other pervasive developmental disorders are reviewed. Modification and application of recent developments in neuroimaging, molecular genetics and population studies are presented. A prioritized list of needed investigations is discussed.

Autistic Disorder↗
PubMedDate not supplied

Rett syndrome: case reports and management strategies.

Rett Syndrome (RS) is a mental retardation syndrome occurring in females consisting of normal pre-, peri-, and neonatal growth and development, followed by rapid regression after 3 but before 30 months, an arrest of the regression and a developmental plateau. The regression results in autistic behavior, with loss of production and comprehension of language, seizures, hyperventilation, characteristic hand-wringing, and ataxic gait. Four case histories of RS from the authors' practice are presented. Management strategies are presented and needed research is suggested.

Adolescent↗
PubMedDate not supplied

A role for biogenic amines in developmental language disorders.

The authors discuss the current uncertainty regarding etiology, treatment, and classification of developmental language disorders (DLD). Referring to previous reports in the literature, they propose a specific subclass of DLD associated with a hypothesized dysfunction of the dopaminergic system of the basal ganglia. Mechanisms of dysfunction and treatment implications are discussed.

Basal Ganglia↗
PubMedDate not supplied

A second visually impaired, mentally retarded male with pervasive developmental disorder, Tourette disorder and Ganser's syndrome: diagnostic classification and treatment.

The authors report a second visually impaired, mentally retarded male who presents with symptoms consistent with atypical pervasive developmental disorder, Tourette disorder, and a syndrome of approximate answers (Ganser's syndrome). Both this case and an earlier reported case are significant in that they identify two children with strikingly similar long-standing symptoms and developmental histories. Since these findings may have broader relevance to children with multiple coexisting disorders, diagnostic and intervention strategies in this population are reviewed.

Adolescent↗
PubMedDate not supplied

Epidemiology of fetal alcohol syndrome in American Indians, Alaskan Natives, and Canadian Aboriginal peoples: a review of the literature.

A critical review of available reports on the epidemiology of fetal alcohol syndrome among American Indians, Alaskan Natives, and Aboriginal peoples of Canada was completed. A search of Medline, the National Institute on Alcohol Abuse and Alcoholism Database, and other relevant data bases was conducted. The reference lists of several publications on fetal alcohol syndrome were reviewed, and four prominent researchers and four government agencies were contacted to identify unpublished articles. This search identified 10 studies, 8 of them cross-sectional. Four of these studies used primary data from the authors' evaluations of children suspected of having fetal alcohol syndrome; the other six used secondary data. The prevalence of fetal alcohol syndrome in the American Indians of the United States and Aboriginal peoples of Canada was consistently high across the 10 studies. These studies have significant restrictions which limit both the confidence in the rates reported and the generalizability of the results. Three studies used data from the province of British Columbia. No study evaluated all children in the study area. Only two studies reviewed death certificates. In only one study were examiners blinded to maternal alcohol use, and no study presented evidence on the sensitivity and specificity of either the screening efforts or diagnostic criteria. Such evidence is especially important in studies of secondary data and in studies that report rates for newborn populations. Studies of the sensitivity and specificity of both the screening and diagnostic criteria for fetal alcohol syndrome would be useful areas for further study. Other study designs, including longitudinal cohort studies, are needed. Additional studies of populations of the American Indians, Alaskan Natives, and Aboriginal peoples of Canada, where low rates of fetal alcohol syndrome are suspected, should be completed. Reviews of death certificates may also bea potentially important source of cases.

Alaska↗