[Increased significance of direct immunofluorescence examination in dermatopathology].
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Fluorescent Antibody Technique↗
Biomedical subjects
L Buhl
Publications and source records attributed to L Buhl.
Urinary hypoxanthine and pseudouridine as indicators of tumor development in mesothelioma-transplanted nude mice.
A human mesothelioma was heterotransplanted to nude mice, and the urinary excretions of hypoxanthine, xanthine, pseudouridine, orotic acid, 7-methylguanine, and 1-methylhypoxanthine have been followed before and after the tumor transplantation. The compounds were measured by means of isotachophoresis, which has been found a rapid and precise method. The tumor reached maximum size within 30 days, and at this time a significantly increased excretion of pseudouridine and hypoxanthine was observed. Tumor growth was stopped by chemotherapy (vincristine, cyclophosphamide, prednisolone, and Adriamycin), and corresponding to this, a decrease occurred in both pseudouridine and hypoxanthine excretion to normal values.
Animals↗
Oxypurine release in cardiac disease. An indicator of general hypoxia in patients with cardiac arrest.
The excretion of hypoxanthine-xanthine and uric acid in urine and the concentrations in peripheral venous blood were determined in nine patients with cardiac arrest due to acute myocardial infarction (AMI), in ten control patients with AMI without cardiac arrest and in nine with angina pectoris. The patients with cardiac arrest showed a 6-fold increase in urinary excretion of hypoxanthine-xanthine 0-2 hours after cardiac arrest. No difference was observed in the uric acid excretion or the hypoxanthine-xanthine and uric acid concentrations in peripheral venous blood. The urinary excretion of hypoxanthine-xanthine increases considerably in connection with reversible cardiac arrest, indicating general tissue hypoxia. No relationship could be found between the duration of cardiac arrest and the increased hypoxanthine-xanthine excretion in the urine.
Coronary Disease↗
Urid acid accumulated in isolated kidney grafts: an assessment of agonal ischaemia.
Hypoxanthine-xanthine washed out from kidney tissue during preservation has previously been found to be a reliable measure of the in vitro assessment of the deleterious effect of ischaemia on the functional regenerative ability of the graft. We have now studied the question: can uric acid accumulation in the isolated kidney graft be employed as a retrospective measure of the agonal ischaemia? We have found that uric acid alone accumulates in renal tissue during the agonal phase, in an amount that remains unchanged during the subsequent in vitro ischaemia. The determination of hypoxanthine-xanthine and uric acid in kidney perfusate samples during preservation must thus be presumed to be an optimal clinical-chemical method of assessing the graft ischaemia.
Adenosine Diphosphate↗
[Drowning accidents of children in private swimming pools in 1965-1974].
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Adolescent↗
Temporofacial zygomycosis in a pregnant woman.
A 38-year-old Omani woman, seven months pregnant, developed extensive zygomycosis involving maxillary and temporal bones. No evidence of any underlying immune deficiency was detected except that which may be attributed to pregnancy. After delivery the patient was treated with repeated courses of amphotericin B, which resulted in a complete clinical resolution. Zygomycosis in uncomplicated pregnancy has not been previously described.
Adult↗
Renal hemosiderosis due to thalassemia: a light and electron microscopy study with electron probe X-ray microanalysis.
A kidney biopsy specimen with pronounced hemosiderosis from a patient with beta-thalassemia major was studied by light and electron microscopy, including X-ray microanalysis. Ferritin was absorbed from the glomerular ultrafiltrate through the parietal epithelial cells and the tubular epithelial cells and from the blood through the endothelial cells. It was transported in siderosomes into the surrounding basal lamina, where electron-dense deposits of hemosiderin were found in the outer part of the lamina densa and the reticular lamina. Fibrosis was seen as a reaction to the iron followed by severe atrophy of affected structures.
Adolescent↗
Late infantile neuronal ceroid lipofuscinosis: an ultrastructural investigation.
Late infantile neuronal lipofuscinosis was confirmed by electron microscopy in this case. At magnifications above 100,000 a particular alternating linear pattern of the curvilinear bodies was found.
Child↗
Lymphangioleiomyomatosis. Is fine needle aspiration cytodiagnosis possible?
Lymphangioleiomyomatosis is a rare condition characterized by a proliferation of the smooth muscle cells, mainly in the lymphatic system, giving rise to blockage of the thoracic duct with chylothorax and chyloascites. This condition was seen in a 34-year-old woman with an abdominal tumor that was subjected to fine needle aspiration. The cytologic diagnosis of this neoplasm is difficult since the cellularity and the cytologic picture indicate malignancy. The organoid configuration together with the chylus formation gave an important clue to the correct diagnosis, which, however, was not made until after a biopsy was performed and the cytologic and histologic findings were combined. The cytologic, histologic and electron microscopic findings are presented.
Abdominal Neoplasms↗