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Biomedical subjects

L Bucci

Publications and source records attributed to L Bucci.

At least 55 records · Page 3Linked to original sources
PubMed1984

Rectal lymphoscintigraphy.

Regional lymph nodes of the rectum are not demonstrable by pedal lymphoscintigraphy. We have evaluated the technique of rectal lymphoscintigraphy, using a technique similar to that which has been used in the assessment of lymph nodes in breast and prostatic cancer. Thirty-five patients were studied: ten normal subjects and 25 patients with rectal cancer. In normal subjects, the lymph nodes accompanying the superior hemorrhoidal artery and the inferior mesenteric artery are demonstrable in succession; after three hours the aortic lymph nodes are demonstrable. The 25 patients with rectal cancer underwent resection of their primary tumor and the stage was defined according to Dukes (1932). In five patients (stage A) no alteration was demonstrable. In 11 patients (stage B) the demonstration of regional lymph nodes was delayed vs. the control group. In nine cases (stage C) the demonstration of regional lymph nodes was delayed and defective versus the control group.

Humans↗
PubMed1984

Short bowel syndrome: clinical manifestations following extensive intestinal by-pass.

A personal experience with 43 cases of end-to-side jejunoileal bypass is reported. Two major clinical entities appear to emerge from the present study and in accordance with data from the literature: liver failure and the so-called enteric disease from bypass. Such observations were confirmed by the results obtained from an experimental investigation on 96 Wistar rats. The fact that the intestinal bacterial contamination seems to be the common cause of both effects and complications of intestinal bypass should limit by itself possible further developments of the procedure.

Diarrhea↗
PubMed1984

Aneuploidy of lymphocytes in familial polyposis coli.

The "in vitro" aneuploidy of peripheral lymphocytes in 13 members of a family affected by familial polyposis coli and in 5 patients affected by familial adenomatosis and belonging to other two families, was examined. The increase in aneuploidy of lymphocytes was significant only in 6 of the 13 members of the family (2 affected by polyposis and 4 not affected) and in all 5 patients with polyposis. Aneuploidy could be, for these reasons, a marker for polyposis.

Aneuploidy↗
PubMed1983

[Functional electric stimulation. Our experience].

The use of F.E.S. in motor rehabilitation should be reserved for cases of central neurological lesions. F.E.S. tends to improve gait, reduce spasticity and improve the transfer of cortical information from the peripheral system. The treatment exploits the possibilities of reprogramming movement by developing new motor circuits and where possible restoring lost movements.

Electric Stimulation Therapy↗
PubMed1982

The central-nervous-system toxicity of long-term oral administration of L-tryptophan to porto-caval-shunted rats.

In a previous paper we have reported that the oral long-term administration of 200 mg/kd of L-tryptophan to rats with a porto-caval shunt causes significant loss of body weight, muscular hypertonicity and aggressivity, as well as marked alteration of the liver structure. We now report that tryptophan administered at the same dosage for the same length of time also induces significant alteration of the central nervous system. These results further demonstrate that high plasma levels of tryptophan are quite well tolerated by control animals but are quite toxic to rats with a porto-caval shunt. We also claim that the brain alterations observed in such animals are not secondary to liver dysfunction but to high levels of plasma tryptophan per se.

Animals↗
PubMed1980

Behavioral, electroencephalographic, and biochemical changes in porta-cava shunted rats.

Behavioral, electroencephalographic, and biochemical alterations have been studied in rats with porta-caval shunt, up to 45--50 days after the operation. No behavioral or electroencephalographic changes have been observed, while modifications of various amino acids both in plasma and brain have been found. Among all the amino acids considered of particular significance are the plasma and brain increases of tyrosine, phenylalanine, and tryptophan, since they are the precursors of biogenic amines. In fact, the increase of 5-HIAA found in regions of CNS which are richest in serotoninergic synapsis could indicate an increased turnover of 5-HT. On the other hand no significant alterations of turnover of catecholamines have been found.

Acetates↗
PubMed1980

Hepatic encephalopathy EEG and octopamine.

In a group of 30 patients with and without hepatic encephalopathy octopamine values were determined and EEG recorded. The data reported show no relationship between octopamine values and presence or seriousness of hepatic encephalopathy but showed a clear correlation between hepatic encophalopathy and electroencephologram disturbance.

Adult↗
PubMed1979

The toxic effects of long-term, oral administration of L-tryptophan in rats with portacaval shunt.

The oral, long-term administration of 200 mg/kg of L-tryptophan to rats previously submitted to a portacaval shunt causes significant loss of body weight, muscular hypertonicity and aggressivity, as well as marked alterations of the liver structure. Conversely, the same treatment is well tolerated by control animals. It is postulated that the derangement of tryptophan metabolism normally occurring in rats with portacaval shunt is by itself insufficient to induce behavioural changes and liver damage, which, on the contrary, develop when tryptophan metabolism is further altered by the administration of the amino acid to the animals for a long period of time.

Animals↗
PubMed1975

[Evaluation of hepatic encephalopathy in portacaval shunts and mesenterico-caval bypass with the jugular vein].

Data relating to 30 patients subjected to side-to-side porta-cava anastomosis and 30 to mesenterico-cava by-pass with the internal jugular vein are presented. At follow-up after a period of over 1 yr, encephalopathy was observed in 40% and 21% of the two groups respectively. Angiography of the coeliac tripod and superior mesenteric showed the existence of a post-operative hepatopetal flow in 80% of porta-cava cases. This incidence was only 30% in the mesenterico-cava group. The relation between the clinical and angiographic data is briefly discussed and neuropsychiatric findings in patients with a picture of hepatic encephalopathy are also presented.

Brain Diseases↗
PubMed1974

The biphasic effect of small doses of tranylcypromine on the spontaneous motor activity and learned conditioned behaviour in rats.

Tranylcypromine (TCP), a monoamine-oxidaone inhibitor with amphetamine-like property, has at first a depressant effect and 5 h later a stimulating effect on sponataneous motor activity and learned conditioned behaviour. This latter effect can be demonstrated by means of a modified conditioned avoidance response schedule and a specific time-schedule interval. While the depressant effect of tranylcypromine may be due to the initial increase of brain serotonin caused by this drug, its delayed stimulating effect is, very likely, related to norepinephrine brain increase occurring a few hours after TCP administration.

Animals↗