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Biomedical subjects

L Brayer

Publications and source records attributed to L Brayer.

At least 37 records · Page 2Linked to original sources
PubMed1977

Chlorhexide and fluoride in prevention of plaque and caries in hamsters.

The effect of combined administration of chlorhexidine and fluoride in the drinking water of hamsters on plaque and caries prevention was studied. Plaque indices of the hamsters receiving chlorhexidine either alone or simultaneously with fluoride were significantly lower than those of the control and fluoride only treated hamsters. The type of plaque indices used in this investigation was area scores. The necessity of quantitatively assessing plaque by several parameters was emphasized. The degrees of caries of the experimental groups were significantly lower than of the control group during the cariogenic diet regime. The anticariogenic effect of chlorhexidine and fluoride at low concentrations each provided simultaneously with a cariogenic diet, was confirmed. The differences in caries rate between the experimental groups were not significant. No additive effect on the cariostatic action of chlorhexidine and fluoride was observed when both reagents were applied simultaneously due probably to the low F concentration in the drinking water. The results did not show a direct quantitative relationship between plaque and caries.

Animals↗
PubMed1977

Effect of fluoride on autogenous iliac cancellous bone and marrow transplants in surgically created intrabony pockets in dogs.

The effect of the osteogenic capacity of fluoride on autogenous iliac cancellous bone and marrow transplants was studied in experimentally created periodontal defects. Eight dogs, 2 years old, weighing between 10 to 15 kg each, were used. The right side of the upper jaw served for creation of the experimental (fluoride-treated) pockets and the left side for the control (saline-treated) pockets. Fluoride treatment was carried out by a single topical application of a high concentration of fluoride in the periodontal defects and by application of a low concentration of fluoride to the bone marrow transplants. Intraoral periapical radiographs were taken immediately after implantation, and at time of sacrifice. Changes during bone healing were assessed histologically and by radioopacity measurements. The newly formed bone in the control and fluoride-treated areas did not differ in quality. Radioopacity in the experimental defects was significantly higher in comparison with that found in the control areas. The increase was probably due to greater bone formation in the fluoride-treated defects. The difference decreased with the duration of the healing intervals. Cementum was deposited in both control and experimental sites.

Alveolar Process↗
PubMed1977

Effect of sodium fluoride rinsing on dental plaque accumulation.

1. Daily rinsing with water does not prevent plaque accumulation and leads to increased levels of gingival inflammation. 2. Toothbrushing or mouth rinsing with sodium fluoride alone decreases plaque accumulation and improves gingival health. 3. The combined method (toothbrushing and rinsing with sodium fluoride) is the most effective. Confirmation of the above results and conclusions requires additional experiments carried out over a longer period of time.

Adult↗
PubMedDate not supplied

Effect of brushing the teeth with a fluoride-containing and fluoridefree dentifrice on the gingiva of dogs.

The effect of brushing the teeth with a fluoride-containing or fluoridefree dentifrice on gingivitis induced by a soft diet was studied in four dogs. Changes in the gingival status were recorded at different stages of the experiment by the gingival indexes, which are a reflection of the external appearance, and by the amount of gingival fluid that is influenced by the pocket depth. The two factors appeared to be directly related although the range of the gingival index was much narrower than that of the amount of gingival fluid. No evident retardation in the improvement of the gingival condition occurred after brushing the teeth with a dentifrice that contained fluoride as compared with using a fluoridefree dentifrice or saline.

Animals↗
PubMedDate not supplied

The effect of sustained-release varnish of chlorhexidine in dental plastic shells on salivary Streptococcus mutans.

The suppression of S. mutans is a predominate factor in preventing tooth decay. Sustained-release-delivery varnish of chlorhexidine was applied to dental plastic shells and administered to eight volunteers to be worn while sleeping. Salivary bacterial samples were taken on days 0, 7, 14, 21, 28, 35. A statistically significant reduction in S. mutans counts was recorded during the course of the study while a non-significant reduction in the total bacterial counts was found. Our results indicate that the application of chlorhexidine in the form of slow-release varnish in plastic shells is an effective intraoral drug delivery system resulting in reduction of S. mutans.

Chlorhexidine↗
PubMedDate not supplied

Topical varnish containing strontium in a sustained-release device as treatment for dentin hypersensitivity.

The purpose of this study was to assess the effect of topical application of a sustained-release device in form of a varnish containing strontium chloride on dentinal hypersensitivity. Sixty teeth were selected in ten patients. The teeth were divided in a) varnish application containing strontium chloride, b) varnish application with no active ingredient, c) untreated teeth. Varnish application was carried out by the patients once daily for 30 days. Results show a marked decrease in hypersensitivity to both mechanical (54%) and thermal stimuli (38%) as compared to the placebo and untreated group.

Delayed-Action Preparations↗