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Biomedical subjects

L Brasseur

Publications and source records attributed to L Brasseur.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

[Update on the pharmacologic approach to pain].

Acute pain can be managed favourably by the use of paracetamol, non steroidal anti-inflammatory drugs, opioids and local anaesthetics, solely or in combination. Sophisticated methods of administration such as nerve blocks or patient-controlled analgesia will improve results. Chronic pain, on the other hand, presents a more complex situation and the pharmacological approach is only one aspect of bio-psycho-social management programmes. The role of opioids in the treatment of chronic non-cancer pain has still not been clarified. Adjuvant drugs are often required.

Acetaminophen↗
PubMedDate not supplied

Pulmonary diffusing capacity for carbon monoxide in simple coal workers' pneumoconiosis.

The lung diffusing capacity for carbon monoxide (DLCO single-breath) and its two components, the capillary blood volume (Vc) and the diffusing capacity of the membrane (DMCO) were measured at rest in 43 miners and 141 control subjects, the values in whom enabled reference formulae to be established; in 30 control subjects and in the majority of the miners these indices were measured during exercise. The main results are as follows: the diffusion indices are on average slightly decreased in simple coal workers' pneumoconiosis; both DMCO and Vc contribute to the lowering of DLCO, at rest and during exercise; individually Vc is more often significantly altered than DMCO; on effort the percentage increase of DLCO is normal in coal miners; the data during exercise suggest that smoking habit contributes more to lowering DLCO than does pneumoconiosis itself; lastly the diffusion indices are lower in miners with "pin-head" than those with micronodular opacities: this tendency is more pronounced during exercise. These findings are discussed.

Adult↗
PubMedDate not supplied

Blood gases in simple coal workers' pneumoconiosis.

Pulmonary gas exchange was measured at rest and during exercise in 30 normal males (14 smokers) and 43 coal workers free of obstructive syndrome, at three levels of oxygenation: hypoxia, normoxia and hyperoxia. The main results are the following: a) in normoxia PaO2 and (A--a)DO2 are slightly abnormal in coal workers at rest and during exercise; b) in hyperoxia (A--a)DO2 and venous admixture are higher in the miners at rest but not during exercise; c) in hypoxia (A--a)DO2 and DLO2 are abnormal in miners as compared with the control subjects; during exercise there is however no difference between the miners and the smokers of the control subjects; d) there is a correlation between PaO2 and (A--a)DO2 during exercise in normoxia and the various diffusion indices; e) (a--A)DCO2 and VD/VT show relatively slight increases in the miners; f) there are several differences between the miners with pin-head images and those with micronodular ones; g) at rest, (a--A)DCO2 and VD/VT are influenced by the degree of oxygenation. These various findings are discussed.

Carbon Dioxide↗
PubMedDate not supplied

[Blood gas measurements and automatization (author's transl)].

The Corning 175, a fully automatic new blood-gas analyzer, was tested and compared with manual analyzers (Eschweiler-Radiometer). The precision was evaluated by means of tonometered bloods and precision gas mixtures. With the Corning 175 four parameters are measured: pH, PCO2, PO2, barometric pressure, and four computed: HCO3-, BE, oxygen content, oxygen saturation. These are automatically corrected for patient hemoglobin and temperature. A microprocessor controls the sequencing of all operations during the calibrations and the measurements and continuously checks the performances of the electrodes and the entire system. The operator part is limited to the introduction of blood. The advantages and the fiability of the automatism in clinical routine are described.

Autoanalysis↗