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Biomedical subjects

L Brand

Publications and source records attributed to L Brand.

137 records · Page 8Linked to original sources
PubMedDate not supplied

Determination of optically active thiopental, thiamylal, and their metabolites in human urine.

Methods involving solvent extraction and gas-liquid chromatography have been developed for quantitative determination of certain thiobarbiturates and their major metabolites in urine. The structures of the metabolites identified were confirmed by the use of gas chromatography/mass spectrometry and 13C-nuclear magnetic resonance spectroscopy. The present analytic methods were applied to the quantitative determination of (R)-(+)- and (S)-(-)-thiopental as well as (R)-(+)- and (S)-(-)-thiamylal and their major metabolites excreted in human urine. Minor metabolites were isolated and identified.

Chromatography, Gas↗
PubMedDate not supplied

[Postoperative digestive complications of thoracic surgery].

The authors investigated the pathologic digestive manifestations that have developed after 2000 surgical interventions in the thoracic-pulmonary field. Four categories of digestive disturbances have been considered: paresis (dynamic ileus), including acute gastric dilation; haemorrhage; mechanical ileus, and digestive perforation. The digestive pathology developed either autonomously or in association with other symptoms of shock. A total of 788 digestive complications have been recorded (39%), of which: 654 cases of dynamic ileus, 118 cases of haemorrhage, 2 cases of mechanical ileus, 4 cases of perforation and 10 cases of mixed complications. In fact haemorrhage is more frequent, haemorrhagic gastritis being found in most of the deceased patients, following prolonged postoperative evolution. The simultaneous or succesive development was noted of digestive complication and respiratory failure in a total of 126 patients (6,3% of the total number of cases investigated). Pulmonary failure became more severe after the onset of dynamic ileus, especially after acute gastric dilatation. The development of any digestive complication represented in all cases an aggravation factor, especially when accompanying respiratory failure. The decrease with time of the incidence of digestive complications, from 57% to 21,8%, is due to changes that have occured in anesthesy techniques, of which NLA appears to play the most important role.

Gastrointestinal Diseases↗
PubMedDate not supplied

[Contribution to the improvement of the results of tracheal surgery].

The authors present, in the light of their personal experience acquired in the performance of surgical interventions on the trachea (a total of 13 interventions in 11 patients), some particularities of the surgical technique, as well as of the anesthetic procedures capable to improve the immediate and the late results of these interventions. The techniques suggested are aimed at preventing the operatory risks in the surgical procedures on the trachea, which is classified by the authors in three groups: tracheal risks, vascular risks, and anesthetic risks. The validity of these techniques is confirmed by the success of the surgical procedures applied, followed by the definitive recovery of the patients which were operated with the most recent experience of the authors. Two clinical observations are presented: a case of circumferential resection of the trachea in the mediastinal portion for cicatriceal stenosis, followed by termino-terminal anastomosis, and a case of cuneiform resection of the trachea in its supracarenal section for tumoral stenosis.

Adult↗