Search PubMed⌕ Search

Biomedical subjects

L Bonomo

Publications and source records attributed to L Bonomo.

At least 235 records · Page 13Linked to original sources
PubMed1981

[Uncommon locations of celomic cysts: a possible cause of error in mediastinal radiology (author's transl)].

Five cases of uncommon locations of mediastinal celomic cysts are presented. All cases were surgically proved. The importance of these locations in the differential diagnosis of mediastinal masses is stressed. The evaluation of their inner structure by computerized tomography is, without doubt, the best progress in radiological diagnosis of the mediastinum. This method allows, atraumatically, to confirm or exclude the cystic nature of the lesion in one with its precise spatial localization.

Adult↗
PubMed1981

[Role of conventional radiology and computed tomography in pre-surgical TNM staging of lung tumours: experience on 41 cases (author's transl)].

Comparison between standard radiographic and CT evaluation with surgical exploration was carried on 41 patients affected by bronchogenic carcinoma. The standard radiographic and CT evaluation was mae only for "T" and "N". In the named 41 patients the surgical evaluation of the anatomic extent (only for T and N) was made. T was underestimated by standard radiographic; on the contrary N appeared underestimated by the two radiological methods.

Humans↗
PubMed1980

Analbuminemia: report of a case and review of the literature.

Idiopathic analbuminemia was fortuitously detected in a 30-year-old Italian woman. No associated disease condition could be revealed in this patient, the only consistent finding being a slight tendency to develop ankle edema. Asthenia and a moderate hypotension were also recorded. Trace amounts (5.2 mg/100 ml) of serum albumin were determined by immunochemical methods. Laboratory features also included increased circulating levels of cholesterol and beta-lipoproteins, as well as elevation of acute phase reactants and immunoglobulins. Albumin turnover studies showed low albumin synthesis and abnormally slow albumin degradation rate. No consanguinity of the percentage could be traced in this patient and an autosomal recessive transmission of the trait was suggested. An extensive review of the literature disclosed 19 additional cases of this rare condition, their occurrence actually challenging the vital role of albumin in man. Compensatory mechanisms certainly play a role but are only partially understood.

Adult↗
PubMed1980

A kinetic test for the assay of the C1 esterase-inhibitor.

The most satisfactory diagnostic procedure for hereditary angioneurotic oedema is the demonstration of low serum levels of C1 esterase-inhibitor. A modified method for the assay of this protein is described. It is based on the kinetic measurement of the C1 esterase-inhibitor when it inhibits the hydrolysis of N-acetyl-L-tyrosine-ethyl ester by C1 esterase. The relative C1 esterase-inhibitor concentration is based on the initial hydrolytic velocity, which can be evaluated from the pH change in a short time and within a small range. High reproducibility, cheap instrumentation and short time of analysis are some of the favorable aspects of this method in comparison with the 'end point titrimetric' method. Furthermore, this paper describes the mechanism of inhibition of C1 esterase by C1 esterase-inhibitor. The results are indicative of a non-competitive mechanism. The value of the Michaelis-Menten constant, Km, is 0.017 +/- 0.001 mol/l at 37 degrees C, in the optimum pH range 7.2-7.4. An estimate of KI in arbitrary units is also given.

Angioedema↗
PubMed1980

The behaviour of beta-2-microglobulin in acute and chronic leukaemias.

Two hundred-one patients (97 leukaemias, 18 lymphoproliferative disorders, 86 solid tumors) were studied for B2M by radioimmune technique. Serum levels were high in all cases, excepting for ALL which presented normal values in 81% of the patients. The follow-up of the microprotein was carried out in 17 patients with acute leukaemias. The data obtained seem to suggest that subjects with high serum levels of B2M at the beginning of the disease do not respond favourably to chemotherapy.

Acute Disease↗
PubMed1979

Macrophages in skin cancer: quantitative and functional studies.

The number of tumor-infiltrating macrophages was estimated in 43 patients with skin cancer, including 18 cases of squamous cell and 25 cases of basal cell carcinoma. Macrophages were identified in cell cultures by 2 assays, namely phagocytosis and resistance to detachment by trypsin. The average percentage of adherent cells for the 2 groups of skin tumors was 4.5 +/- 2.6 and 10.2 +/- 5.2, respectively, and the difference was statistically significant. Follow-up studies after surgical excision of the primary neoplasm showed a relatively low macrophage content in 2 of the 4 cases in which local recurrences occurred. Preliminary functional studies suggested that soluble factors may be released by neoplastic cells, accounting for the inhibitory effect of tumor cell supernatants on macrophage chemotaxis in vitro.

Adult↗
PubMed1979

Immunological and bacteriological studies in chronic pyelonephritis associated with kidney stones.

Histological and immunofluorescent techniques, urine, stone and renal fragment culture, demonstration of bacteria with fluorescent specific antisera in the renal tissue and determination of circulating antiGBM and antiTBM antibodies in the serum, were studied on the renal biopsies of 46 patients with chronic pyelonephritis (CPN) associated to kidney stones. Results show that the bacteria are often present in renal tissue of CPN with negative urine culture. The presence of C3 and C4 in some cases, and C3 and C3PA in others, at the tubular level associated with bacteria, suggest that the activation of the C system may be through the classic way, i.e., through the bacteriological immune complexes, or the alternate pathway, i.e., through the bacteria or their products. In conclusion, the evolution of the CPN may be related to the activation of the C system and the coagulation mechanism, as shown by frequent fibrinogen deposits.

Adolescent↗
PubMed1978

[Aneurysmal dilatation of the superior vena cava].

A case of aneurysmatic dilatation of the vena cava superior is presented. This lesion is rare and not commonly taken into consideration in the differential diagnosis of anterior mediastinal masses. Chest X-rays taken during inspiration and expiration and in the standing and reclining positions (particularly the second and fourth) revealed changes in the size of the mediastinal mass and pointed clearly to its venous nature. This deduction was then confirmed angiographically.

Adult↗
PubMed1978

Adenosine deaminase activity in acute lymphoblastic leukaemia: cytochemical, immunological and clinical correlations.

Adenosine deaminase (ADA) activity has been assessed in lymphoid cells of 23 patients with acute lymphoblastic leukaemia (ALL) in order to attempt a further characterization of ALL cells in addition to the well known cytochemical and immunological T and B lymphoid cell markers. ADA activity did not show any correlation with the immunological characterization of the patients investigated; in fact a wide range of ADA activity was observed with levels ranging from 0 to 32 U in T-ALL patients and nearly similar values (from 1.8 to 36 U) in the group of non T--non B ALL cases. Normal values ranged from 2 to 5 U (mean 2.9 U; s.d. +/- 0.8). Some cytochemical patterns (acid phosphatase and PAS) appeared well correlated with T markers of lymphoid cells, whereas they showed no significant relationship with ADA activity.

Acid Phosphatase↗
PubMed1978

Cryoimmunoglobulinemia in four sisters.

Mixed-typed cryoproteins, consisting of IgG and IgM, were demonstrated in the sera of four sisters. While the IgG component was polyclonal in every instance, in two of them the IgM component was found to be monoclonal with type chi light chains. Clinical diagnoses included the purpura-weakness-arthralgias syndrome, posthepatitis cirrhosis, congestive heart failure and mitral stenosis. The cryocrit differed in the four sisters, ranging from 3 to 16%; in addition, rheumatoid factor activity was consistently associated with both washed cryoprecipitates and their isolated IgM components. Endomembraneous deposits of IgG and IgM were revealed by immunofluorescent studies of the renal biopsy specimen from one patient. A genetic abnormality, possibly of the autosomal recessive type, is suggested in this instance of familial cryoglobulinemia.

Aged↗
PubMed1978

[3 cases of cardiac echinococcosis. Diagnostic considerations].

Three cases of cardiac hydatidosis are described, with emphasis on electro-vectorcardiographic, policardiographic and angiographic data. The cysts, plurime in two patients, were localized in different sites: in the first patient only one cyst was present in the interventricular septum; in the second one there were cysts in the right atrial wall and in the diaphragmatic ventricular wall; in the last one a multilocular disrupted sac involved the left ventricular wall partially occupying the left ventricular cavity. Multiple pericardial cysts were also present in this patient. The usefulness of different invasive and non invasive techniques is here discussed regarding topographic diagnosis of cardiac hydatidosis.

Adult↗