Biomedical subjects
Publications and source records attributed to L Bondeson.
The distinct cytologic picture of a fine needle aspirate from a case of adult rhabdomyoma is described. The presence of cytoplasmic cross striations was a diagnostic feature that could be demonstrated in some tumor cells with all routine stains used (Papanicolaou, May-Grünwald-Giemsa and hematoxylin and eosin).
From a case illustrated, it appears that irradiation may induce changes in normal breast epithelium indistinguishable from malignancy by means of aspiration cytology. This fact must be considered in the choice of diagnostic methods for the evaluation of lesions in irradiated breast tissue.
The cytology of adenoma of the nipple in a fine needle aspirate has so far not been reported. Such a case is described, and the very important cytologic distinction of this lesion from Paget's disease is emphasized.
Aspiration cytology from four benign dermal eccrine cylindromas and five adenoid cystic carcinomas were compared. These two lesions were found to have so much in common morphologically that they may be indistinguishable on a purely cytologic basis. Accordingly, we recommend a restricted excision to obtain a histopathologic diagnosis before more extensive surgery is performed whenever a lesion is cytologically consistent with adenoid cystic carcinoma but clinically shows a picture that does not exclude dermal eccrine cylindroma.
Morphometry was applied to smears of fine needle aspirates from 26 oxyphilic thyroid neoplasms. Thirteen tumors were considered benign as judged from histologic findings and clinical follow-up for 2 to 20 years after the operation. Thirteen tumors were considered malignant histologically; four of these had proven metastases. In each case the mean and standard deviation of the projected nuclear area were calculated from 200 nuclei in the smear. Our results indicate that morphometric estimation of mean nuclear size and/or degree of anisokaryosis is of no practical value in distinguishing between benign and malignant thyroid neoplasms of the oxyphilic type.
The cytologic picture of fine needle aspirates from a rare type of breast carcinoma with stromal proliferation of osteoclastlike giant cells is described. Cytochemical demonstration of nonspecific esterase activity in the giant cells is in accordance with the assumed histiocytic origin of these elements.
The cytologic findings in the cerebrospinal fluid in a case of primary intracranial epidermoid carcinoma are presented. The presence of a few squamous cells showing hyaline cytoplasm compatible with keratinization suggested the possible nature of the tomographically observed lesion. These tumors may arise in congenital epidermoid cysts at the base of the brain. Because of their location and meningeal spread, such tumors may cause severe symptoms and death despite a minute size, as illustrated by this case.
The light and electron microscopic appearance of fine needle aspirates from a case of a solid and papillary neoplasm of the pancreas is described. This rare type of tumor, which is often large when detected and usually occurs in young women, has a favorable prognosis if treated surgically. Thus, it is important to distinguish this lesion from other pancreatic neoplasms with regard to the choice of therapy. Possible cytologic differential diagnoses and the aid of electron microscopy in this context are discussed.
OBJECTIVE: To draw attention to some hitherto unnoticed clinicopathological aspects of primary hyperparathyroidism in patients who develop hypercalcaemic crisis. DESIGN: Retrospective review of records and histopathological archive material. SETTING: University hospital. SUBJECTS: 54 patients treated for primary hyperparathyroidism with hypercalcaemic crisis between 1961 and 1988. MAIN OUTCOME MEASURES: Correlation of age, serum calcium concentration, histopathological appearance and size of tumours associated with hypercalcaemic crisis. RESULTS: 11/54 (20%) of the patients with hypercalcaemic crisis were younger than 40 years of age. Among 460 patients treated at the same hospital for primary hyperparathyroidism without hypercalcaemic crisis, 23 (5%) belonged to the same age category (p less than 0.001). There was no difference between the two groups of patients regarding histopathological characteristics, with the exception of mitotic activity which was remarkably high in some benign lesions causing hypercalcaemic crisis. The correlation between tumour size and degree of hypercalcaemia was poor, and one-third of the adenomas did not exceed 2 cm in diameter. CONCLUSIONS: Young age is a risk factor regarding the development of hypercalcaemic crisis in primary hyperparathyroidism; the proportions of the pathological entities causing hypercalcaemic crisis do not differ markedly from other cases of primary hyperparathyroidism; the correlation between adenoma size and degree of hypercalcaemia is poor; oxyphil adenomas are as likely to be associated with hypercalcaemic crisis as other types of parathyroid adenoma; and some benign parathyroid lesions associated with hypercalcaemic crisis (hyperplastic glands as well as adenomas) show high mitotic activity.