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Biomedical subjects

L Bodner

Publications and source records attributed to L Bodner.

At least 55 records · Page 3Linked to original sources
PubMed1991

Lipid pigment (lipofuscin) accumulation in rat tongue muscle with aging.

Lipid pigment (lipofuscin) was examined in perioral and tongue muscles of aging rats. While in perioral striated muscle the pigmented granules could not be found, a considerable accumulation with aging could be noted in the tongue muscle. Unlike the human tongue muscle, in which the pigmented granules were stored in clusters of different sizes at the nuclear poles of the muscle fibers, in rats, they were scattered randomly through the cytoplasm. The results of this study suggest that lipofuscin can be used as a marker for aging of the tongue muscle in the rat.

Aging↗
PubMed1991

Intravascular papillary endothelial hyperplasia of the mandibular mucosa.

Intravascular papillary endothelial hyperplasia (IPEH) usually presents as a cutaneous lesion consisting of a reactive proliferation of endothelial cells that arise in an organizing thrombus. This lesion can easily be mistaken for an angiosarcoma. Oral presentations are rare, and when they do occur the most common site is the lip. A rare case of IPEH affecting the mandibular buccal mucosa is described.

Connective Tissue↗
PubMed1991

Extraction wound healing in desalivated rats.

Wound licking has been shown to promote extraoral wound healing among animals. Although the oral mucosa is bathed in saliva. Little information about the role of saliva in oral wound healing is found. The present study evaluates the healing of extraction wounds in desalivated rats. Experimental rats underwent sialadenectomy of the submandibular and sublingual glands and ligation of the parotid ducts. Maxillary left first molars were extracted. Rats were killed at 0, 1, 3, 5, 7, 10, 14, and 21 days after surgery and maxillae were prepared for light microscopy examination. Generally, a delay in socket healing in the desalivated rats was found. No differences were observed in blood clot formation. Replacement of the clot by granulation tissue was relatively slow concomitant with a longer inflammatory process. Bone formation kinetics were slower among the experimental rats.

Animals↗
PubMed1991

Salivary gland cysts of the oral cavity: clinical observation and surgical management.

Mucoceles are common cystic lesions of the oral mucosa. Extravasation mucoceles are mainly found in the lower lip of young patients, whereas retention mucoceles are usually located in the cheek or palate of older patients. The disparate site and age incidences of extravasation and retention mucoceles suggest that these two types are not related and have different pathogenesis. Treatment modalities for mucoceles are reviewed, with special attention to the cryosurgical technique for the treatment of oral ranulas.

Adolescent↗
PubMed1989

Transport of alpha-aminoisobutyric acid into rat parotid after X-irradiation.

Rat parotid gland exposed to 20 Gy X-irradiation exhibits functional alteration 3 days after exposure. The flow rate of saliva and the uptake of alpha-aminoisobutyric acid by the gland was reduced to 50 per cent of values for the control nonirradiated glands. When the same gland was studied in an in vitro system it functioned normally. K+ release and alpha-aminoisobutyric acid uptake by the irradiated dispersed acinar cells was comparable to the control. Transport alteration from the circulatory system into the parotid gland may cause the initial radiation-induced damage.

Aminoisobutyric Acids↗
PubMed1988

Age-related impairment in rat parotid cell alpha 1-adrenergic action at the level of inositol trisphosphate responsiveness.

Alpha 1-Adrenergic-stimulated calcium efflux from rat parotid cell aggregates declines approx. 40% between 3 and 24 months of age, with the bulk of the reduction occurring between 12 and 24 months. Intracellular free calcium levels following alpha 1-adrenoceptor stimulation are also reduced about 40% between 3 and 24 months. No significant age differences in stimulation of inositol mono-, bis- or trisphosphate production are observed. However, the ability of inositol trisphosphate to directly stimulate calcium efflux is reduced by about 50% with increasing age. Concentrations of this inositol phosphate required for maximal calcium release do not change between 3 and 24 months. Differences in response are not due to a reduction in uptake of inositol trisphosphate into older cells, but suggest an age-related defect in the ability of inositol trisphosphate to liberate calcium from intracellular stores. Such dysfunction may be at least partially responsible for impaired alpha 1-adrenergic responsiveness during aging.

Age Factors↗
PubMed1988

Dentigerous cysts associated with supernumerary teeth.

Dentigerous cysts associated with supernumerary teeth are rare and estimated to constitute 5-6% of all dentigerous cysts. They resemble the usual dentigerous cysts in terms of sex predilection and age distribution. The vast majority, about 90%, are associated with a maxillary mesiodens. The literature is reviewed and 6 additional cases reported.

Adult↗
PubMed1987

Growth potential of peripheral ossifying fibroma.

The peripheral ossifying fibroma (POF), a benign gingival overgrowth, occurs mainly in the anterior portion of the maxilla in young adults. The size of the lesion is usually less than 1.5 cm. A unique case of POF in the posterior mandible of a 70-year-old female is presented. The lesion was 6 cm in the largest diameter. It is apparent that POF can become a sizeable tumor unless it is surgically excised in an early stage.

Aged↗
PubMed1986

Cytomegalovirus colitis in acquired immune deficiency syndrome: radiologic spectrum.

Six cases of cytomegalovirus (CMV) colitis are described. The radiographic manifestations of this colitis are nonspecific and usually mimic the findings of ulcerative colitis with diffuse mucosal ulceration or granulomatous colitis with aphthous ulceration and skip areas. Terminal ileal involvement was noted in 1 patient. Nonspecific edema was present in 2 other cases. One patient demonstrated unusual cecal and ascending colonic nodularity due to pseudomembranes and, in another, large, flat discrete ulcerations were identified. Angiography, in 1 case, demonstrated marked hypervascularity and identified a site of hemorrhage in the ascending colon. With the radiographic identification of colitis in an immunocompromised patient, particularly a patient with acquired immunodeficiency syndrome (AIDS), CMV colitis must be strongly considered in the differential diagnosis. Endoscopic biopsy is the most effective method of establishing the diagnosis.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Assessment of age-related changes in the submandibular and sublingual salivary glands of the rat using stereological analysis.

The histological structure of these glands was examined in male rats in two adult age groups. In the submandibular gland, the proportional volume of acinar tissue at 6 months was reduced by 17 per cent at 24 months, being replaced partly by an increased proportion of ducts and partly by increased fibrosis. No volumetric changes occurred in the granular tubules. In the sublingual gland, no volumetric changes were detected in any component tissues. The findings support the concept that biological ageing in the salivary glands does not occur as a uniform generalized process throughout all the salivary tissues.

Aging↗
PubMed1986

Uptake and secretion of technetium pertechnetate by the rat parotid gland.

The ability of acinar cells of the rat parotid gland to transport technetium pertechnetate (99mTcO-4) was examined. After intravenous injection, 99mTcO-4 was rapidly detected in parotid saliva. There was an excellent correlation between saliva and plasma 99mTcO-4 levels. The saliva to plasma ratio was always less than 1, consistent with the inability of rat parotid gland duct cells to concentrate the anion. Output of 99mTcO-4 by the parotid gland closely mimicked fluctuations in parotid saliva flow rate. In vitro, enzymatically dispersed parotid acinar cells accumulated 99mTcO-4 from the incubation medium in a biphasic manner. This uptake was partially blocked by 10(-4) M NaI. Cells which had accumulated 99mTcO-4 showed increased radionuclide efflux after exposure to 10(-5) M carbachol.

Animals↗
PubMed1985

Characteristics of stimulated parotid gland secretion in the aging rat.

The production of pilocarpine-stimulated parotid saliva was evaluated in young adult and aged male and female rats. Parotid salivary flow rate was about 50% lower in aged animals of both sexes. Saliva of aged animals had the same Na+ concentration as that of young rats but contained about 40% more protein. Salivary K+ concentration was similar in young and aged males but not females.

Aging↗
PubMed1985

Emergency combined angiographic and endoscopic Neodymium-YAG laser treatment of a complicated case of massive upper gastrointestinal hemorrhage.

Emergency combined angiographic and endoscopic Neodymium-YAG laser treatment is described in an elderly patient with massive hemorrhage from the afferent limb stump of a Billroth II anastomosis after surgical resection of a gastric carcinoma. In patients with bleeding lesions, who are not operative candidates, such an approach can be life-saving.

Aged↗
PubMed1984

Submandibular gland secretory function in young adult and aged rats.

An evaluation of submandibular gland secretory function was performed in young adult and aged male and female rats. No significant alterations in submandibular salivary flow rate or the concentrations of total protein, Na+,K+ and neutral sugar in the secreted saliva, were observed between different aged animals. Significant sex differences in salivary flow rate and total protein content were found.

Aging↗