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Biomedical subjects

L Blum

Publications and source records attributed to L Blum.

At least 73 records · Page 4Linked to original sources
PubMed1991

M. leprae- and BCG-induced chemiluminescence response of monocytes from leprosy patients and healthy subjects: effects of gamma-interferon and GM-CSF.

Mycobacterium leprae, in contrast to BCG, failed to trigger any chemiluminescence (CL) response in mononuclear cells from either leprosy patients or healthy subjects, a deficit not reversed by either interferon-gamma or GM-CSF. Chemiluminescence responses induced without mycobacteria or with BCG were found to be lower in leprosy patients than in controls. M. leprae were also less well phagocytosed than BCG. However, there was a significant difference in phagocytosis between healthy and tuberculoid leprosy subjects. Phagocytosis was not altered by the addition of either lymphokine, and no major differences between healthy subjects and patients were observed. Preincubating mononuclear cells with anti-mycobacteria antibodies (lepromatous patients' sera) did not increase the CL response nor the phagocytosis of M. leprae or BCG.

Antibodies, Bacterial↗
PubMed1990

Zones of the uterus: discrepancy between US and MR images.

The location of the boundaries among the endometrium, inner myometrium (dark), and outer myometrium (intermediate or bright) were compared on T2-weighted magnetic resonance (MR) and intravaginal ultrasound (US) images obtained within 24 hours of each other. Twelve women with normal reproductive cycles underwent a total of 21 pairs of examinations. The endometrium, inner myometrium (junctional zone), and outer myometrium were measured by three independent observers. The endometrial thickness was thinner with MR imaging (6.5 mm with MR imaging vs 7.9 mm with US early in the cycle [P = .001]; 9.9 mm with MR imaging vs 11.3 mm, respectively, late in the cycle [P = .045]). The junctional zone was thicker with MR imaging (4.4 vs 2.3 mm early [P less than .001]; 3.9 vs 2.2 mm late [P = .003]). The combined thickness of the endometrium and junctional zone was thicker with MR imaging (15.5 vs 12.7 mm early [P = .002]; 17.3 vs 15.8 mm late [P = .064]), confirming that the boundary between the junctional zone and outer myometrium is different with MR imaging versus US.

Adult↗
PubMed1990

Usefulness of a short femur in the in utero detection of skeletal dysplasias.

In 28 fetuses studied during a 4 1/2-year period, the initial femur was below 2 standard deviations (SDs) of the mean when compared with the biparietal diameter. These fetuses were considered at risk for skeletal dysplasias and were followed up. Studies were performed at a mean gestational age of 26.7 weeks (range, 15.3-41.0 weeks). Group 1 had a femur length 1-4 mm below the 2-SDs line (range, -2.0 to -4.0 SDs); no other abnormalities were detected. Interval examination of 12 femurs showed that 10 either remained shortened to the same degree or had a growth spurt. At birth, all subjects were healthy except one with mild growth retardation and one with a chromosomal abnormality. Of the two subjects that failed to continue normal growth, one was healthy and the other was a heterozygous achondroplastic dwarf. Group 2 had greater femoral shortness; all measurements were more than 5 mm below the 2-SD line (range, -4.3 to -31.0 SDs). All had fetal abnormalities and significant skeletal dysplasias. The authors conclude that the number of millimeters below the 2-SDs line is an accurate, easy criterion for evaluation of femoral length.

Bone Diseases, Developmental↗
PubMed1989

[Macrophage activation and Mycobacterium leprae: effect of interferon gamma on the production of oxygen free radicals by phagocytic cells].

Activation of the respiratory metabolic channel (F.O.R.), responsible in part for the bactericidal effect, was measured in vitro by a chemoluminescence test on circulating phagocytes. All mycobacteria tested, except for Mycobacterium leprae, induced a significant response. Its effect on lepromatous leprosy pathology is a subject for discussion.

Free Radicals↗
PubMed1983

Alcoholism in the elderly: an analysis of 50 patients.

The personal, demographic, and socioeconomic aspects of alcoholism in 50 elderly and 50 young alcoholics were examined. A higher number of elderly alcoholics were veterans, widowed, and had a long history of alcoholism when compared with younger alcoholics. During drinking bouts, the younger alcoholics had more blackouts, hallucinations, sleeping difficulties, and loss of appetite than did the elderly alcoholics. These findings must be interpreted with caution in view of the small sample size and the fact that geriatric alcoholics are not a homogeneous group.

Age Factors↗