Biomedical subjects
Publications and source records attributed to L Blom.
Recently, physiotherapy students in Denmark have been spending part of their hospital training period in a factory environment, studying working postures and work methods. It is concluded that physiotherapists so trained can provide patients with a better service and treatment through their improved knowledge of the causes of illness.
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Groups of rats were fed biphenyl at various dose levels in a semisynthetic diet and in a commercial chow. The effect levels for induction of polycystic kidney lesions were established by means of urinalysis, organ weight changes, light and electron microscopy, and enzyme histochemistry. The no-effect level, was less than 50 mg/kg bw./day and 300 mg/kg bw./day, when feeding the semisynthetic diet and the commercial chow respectively. This difference in effect level due to the diet is an indication that the diet is of great influence on the results of toxicological experiments.
Ulberg's whole-body autoradiographic technic has been used to illustrate the distribution pattern, the uptake to the oocytes and the excretion into the egg-white of 14C-trimethroprim, 3H-tetracycline and 14C-urea in Japanese quails. Marked differences were found in the uptake by the follicular epithelium between the oocytes of different size. Furthermore it is observed, that the part of the compound which reaches the yolk remains there, while the rest of the compound is excreted from the body. In the oviduct, the compounds showed variations in the distribution pattern between the differen parts, apparently according to the passive diffusion concept. Some of the drugs showed peculiar localisation in high concentrations as in the retina and in the pecten of the quails eye.
The laboratory animal is susceptible to biological variation due to a variety of causes. Thus genetic variation and nutrition have become recognized to influence the reaction of the animal to experimental procedures. Severe kidney injury was observed at our institute in preliminary studies with 1% butylated hydroxytoluene (BHT) incorporated in a semisynthetic diet fed to Wistar rats for one month. These lesions together with nephrocalcinosis, a common finding in rats fed a semisynthetic diet might suggest that the animals in our experiment were predisposed to kidney damage. In order to show the influence of the rat strain and the type of diet a study was performed with both Wistar and Sprague-Dawley rats fed a semisynthetic or commercial diet mixed with 1% BHT. It was observed that the semisynthetic diet had a marked effect on the severity of the kidney lesions and that the lesions were independent of the rat strain used. In addition, an apparent sex variation was found.
1. Injection sites were examined on the 7th d after intramuscular injection of vehicles alone or containing antibiotics or chemotherapeutics. 2. Eight out of 13 preparations caused necroses, the largest of which were seen after injection of tetracyclines and sulphonamides.
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Glycosylated hemoglobin A (HbA1c), considered to reflect long-term metabolic control of diabetes, was analyzed in 131 patients, aged 2 5/12-19 6/12 yr, with juvenile-onset diabetes. Using stepwise multiple regression HbA1c, fasting blood glucose and plasma 3-hydroxybutyrate were analyzed as dependent variables versus independent variables such as age of the patients, duration of the disease, level of plasma immunoreactive C-peptide (IRCP), insulin dose, and number of insulin injections (one or two) per day. HbA1c was inversely related only to IRCP concentration. A low but significant, positive correlation was found between HbA1c and the duration of diabetes. Stepwise addition of the other independent variables did not further increase the fraction of explained variance. HbA1c was also correlated with a subjective rating score of the metabolic control performed by the treating physician. Fasting plasma glucose was significantly related to HbA1c but not to any of the independent variables. Fasting 3-hydroxybutyrate showed an inverse correlation to the age of the patient. The present study showed that in juvenile-onset diabetic patients, endogenous insulin secretion as reflected by IRCP was the factor best correlated with a low level of HbA1c. After the cessation of endogenous insulin secretion, there is a progressive deterioration of metabolic control and multiple injections of insulin rather than one or two per day may be needed to reach optimal control in the patients.