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Biomedical subjects

L Bianco

Publications and source records attributed to L Bianco.

At least 37 records · Page 2Linked to original sources
PubMed1983

Effect of ibopamine on peripheral haemodynamics.

Peripheral haemodynamics was studied in healthy volunteers by strain gauge plethysmography after administration of ibopamine (IB), diisobutyric ester of N-methyl-dopamine, an orally active dopaminergic agonist. Seven subjects received a single oral dose of ibopamine of 150 mg and 6 received a daily dose of 150 mg (50 mg t.i.d.) for 5 consecutive days. Arterial resting blood flow and venous capacity increased and peripheral resistance decreased significantly. Six further subjects were then studied; 3 h after an oral dose of ibopamine 150 mg, the parenteral administration of Sulpiride 50 mg, a specific vascular dopaminergic antagonist, was found significantly to counteract its peripheral activity. Heart rate and arterial blood pressure were never affected and tolerability was good.

Adult↗
PubMed1978

[Preoperative renutrition in patients with esophageal stenosis].

UNLABELLED: 50 patients suffering from dysphagia and oesophageal stenosis were treated in the period 1975-77. Of these 31 had renutrition of longer than two weeks and are the subject of the present study. Three nutrition systems were employed: 1) total parenteral feeding (7 patients), 2) feeding by naso-gastric tube or gastric fistula (15 patients), 3) feeding per os with semiliquid foods (9 patients). The patients were suffering from benign cicatricial stenosis (5), tumours of the cardia (7), tumours of the oesophagus (19). Short-term survival, weight behaviour and the course of certain blood parameters (Hb, GR, cholesterol, albumin, total proteins) are reported. CONCLUSIONS: --in benign cicatricial stenosis and tumours of the cardia, a normal protein-caloric amount (2000-3500 KCal., 80-120 g/24 h of proteins) is sufficient to obtain weight increase and stabilization of blood examinations. The administration route is unimportant; --in malignant stenosis, 4000-6000 KCal. and 100-130 g of protein/24 h must be provided to obtain the same result. In patients treated with total parenteral nutrition the weight loss persists. The reason for this behaviour is not known; it is likely that enzymatic blocks exist in substrate utilization; --further study is needed to improve results obtained and to clarify the reasons for such behaviour.

Adult↗
PubMed1973

[Not Available].

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China↗
PubMedDate not supplied

[Insulin response to food in obese women].

The effects of two standard meals (meal A: 20 g proteins, 20 g lipids, 80 g maltodextrin; meal B: meal A plus 52 g lipids) on insulin and C-peptide secretion and on plasma levels of glucose and free fatty acids (FFA) was studied in 12 obese women separated into two groups according to the onset of obesity. One group (n = 6) developed into obesity after puberty (OP), the other (n = 6) became obese after pregnancy (OG). Meals A.--In OP women, the maximum insulin response was reached at 30 min after meal (141.8 +/- 14.2 microU/ml) and insulinaemia fell to the basal values at 180 min; in OG women the insulin response was linear in the interval 30-150 min after meal. The maximum secretion of C-peptide occurred between 30 min and 90 min in OP and between 60 min and 120 min in OG; the secretion rate was similar in the two groups. Blood glucose levels returned to the basal values at 120 min after meal in OP and at 180 min in OG. FFA levels significantly decreased after meal in both groups (p less than 0.01 vs basal values). Meal B.--Insulin secretion was decreased at 30 min after meal in OP and at 150 min in OG and the levels of C-peptide was not modified in both groups. The glycaemic response was unchanged in OP, but was lower in OG women (p less than 0.02). These results show that OP women present stronger and more rapid insulin response to meals than the OG women; this conclusion is supported by the analysis of the secretion of C-peptide. Blood glucose levels return to basal values faster in OP than in OG women. The blood level of FFA after the standard meals A and B are normal both in OP and OG women.

Adult↗
PubMedDate not supplied

[The role of vitamin E in the therapy of thalassemia].

Serum vitamin E values are depressed in thalassaemia owing to increased consumption because of the oxidative stress imposed both to red cells and other tissues by haemochromatosis. A study of vitamin E deficiency was carried over a period of about 2 years in 161 transfusion dependent thalassaemic patients aged 4 months to 18 years (including 74 splenectomized subjects) all following the same transfusion and chelation protocol (pretransfusion Hb = 11 gr/dl and daily chelation with subcutaneous infusion of desferrioxamine 12 hr a day). Serum vitamin E levels were determined by Martinek's method. The mean value for the entire series was 0.45 +/- 0.21 mg/dl (normal value 0.76 +/- 0.22), with no differences between splenectomized (0.43 +/- 0.19) and not--splenectomized (0.45 +/- 0.21) subjects. Values of less than 0.32 mg/dl (mean-2SD) were found in 50 patients (31,1%). Below--normal values were noted in 5/11 patients at the time of diagnosis. 124 subjects with less than 0.54 mg/dl received 5-10 mg/Kg/day vitamin E per os. In 38 cases it has been possible to control vitamin E level after one year of therapy. Mean values before treatment were 0.36 +/- 0.13 mg/dl and 1.19 +/- 0.35 mg/dl after therapy. No patient failed to respond and no adverse effect was recorded. These results show that by no means all thalassaemic patients are vitamin E deficient to the point where replacement therapy is necessary, and oral administration can easily correct low serum levels, contrary to what has been found by other workers.

Adolescent↗