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Biomedical subjects

L Bette

Publications and source records attributed to L Bette.

At least 55 records · Page 3Linked to original sources
PubMed1978

Radioisotopic diagnosis and quantitation of left to right shunts in childhood and adolescence.

In 187 patients (141 adults and 46 children) left to right shunts were assessed using quantitative radionuclide angiography. After injection of 99mTc into the femoral vein time activity curves were registered over both lungs and the heart (Ohio Nuclear Camera, ON SIGMA 400, 110, HP 5407 computer). Using a modified gamma function area ratio technique the shunt sizes were calculated. The radioisotopic method allows a precise quantitation of left to right shunts ranging from 15--80%. There was a good agreement between the shunt sizes calculated by the radioisotopic method and oximetry or dye-dilution at cardiac catheterization (adults r = 0,87, children r = 0,85). The shunts sizes assessed with this nontraumatic method appear sufficiently reliable to be a real alternative to conventional techniques in screening for shunts.

Adolescent↗
PubMed1978

[Coincidence of malformations of the cardiovascular system as well as of the kidneys and of the efferent urinary tract (author's transl)].

Excretion urograms were prepared subsequent to angiocardiograph in a total of 115 cardiac catheter examinations. 104 of these examinations were evaluated. In 17 cases (16.3%), malformation of the kidney or the ureter was found. In consideration of the fact that such fundings are often directly linked to therapeutic consequences (plastic operations), the additional preparation of an excretion urogram is indicated during cardiac catheter examinations.

Angiocardiography↗
PubMed1978

[Determination of cardiac output and ejection fraction using radionuclide angiography. A comparsion with conventional diagnostic methods in cardiology (author's transl)].

Cardiac output and ejection fraction of left and right ventricle were determined in 75 patients with different heart diseases applying a newly developed method which combines radionuclide angiography and triggered blood pool scintigraphy. The comparison of cardiac output and ejection fraction as determined by dye-dilution or thermodilution technique and left ventricular angiography is excellent (coefficient of correlation r equal to 0.86 and r equal to 0.91). Cardiac output and ejection fraction can be determined with this method in single non-invasive operation, i.e. under physiological conditions. The ejection fractions can be determined with high statistical accuracy from time-activity curves of both ventricles. Similar to cine-angiography it is possible to evaluate the ventricular volume, the regional contraction patterns and aneurysmata. Outpatients can be investigated in 30 min. Since the radiation dose in comparison to cine-angiography is very low, this investigation can be repeated several times without harm to the patient. There are no risks as described for cardiac catheterization and contrast angiography. Patients with low cardiac output and ejection fraction can be classified as "high risk patients". In these patients cardiac catheterization can be avoided by applying the described method.

Cardiac Output↗
PubMed1976

[Effect of cardiac catheter investigations and angiocardiography on enzyme activity in serum (author's transl)].

The serum activities of LDH, alpha-HBDH, CK, GOT and GPT wer investigated in 124 patients who had undergone cardiac catheterization with angiocardiography or coronary angiography. The determinations were made before and 2, 16 and 40 hours after the investigation. There was no significant influence on the enzyme activities. Lengthy intracardial catheter manipulation, trans-septal puncture and ventriculography may cause transient clinically unimportant increases in activity, especially of CK within normal limits. Distinctly pathological enzyme values were only measured in individual cases of intramyocardial contrast media depots after ventriculogram.

Adult↗
PubMed1976

[Influence of a pressure agent on blood concentrations of glucose, lactate, pyruvate and free fatty acids (author's transl)].

In 34 unselected patients blood concentrations of glucose, lactate, pyruvate and free fatty acids (FFA) were determined after i.v. injection of a pressure agent containing theophylline esterified with norephedrine and theophylline esterified with norepinephrine (Akrinor) with and without beta-adrenergic blockade. After Akrinor a significant increase of FFA concentration of 32% is observed, which can be abolished by beta-receptor blocking agents. Our findings indicate that the Akrinor-induced lipolysis is mainly due to a direct sympathomimetic effect on the beta-receptors of adipose tissue. there are only slight effects on carbohydrate metabolism (decrease of pyruvate concentration, increase of lactate/pyruvate ratio) which are not influenced by beta-receptor blockade. According to our results there are important metabolic differences between Akrinor and the classical catecholamines.

Blood Glucose↗
PubMed1975

[Effect of Akrinor on cardiovascular-dynamics before and after blockade of adrenergic beta-receptors by propranolol].

On healthy volunteers it is tested whether the cardiovascular and central stimulating effect of Akrinor and the depressive effect of propranolol influence each other mutually. Akrinor causes an increase in arterial pressure, in cardiac stroke volume and cardiac output in connection with a decrease in peripheral vascular resistance and in heart rate. These changes are abolished by propranolol whereas the central stimulating effect on the respiratory minute volume and the oxygen consumption is not influenced. After blocking of the beta-receptors, Akrinor exerts a diminished influence on the cardiovascular dynamics, a stimulation of the alpha-receptors cannot be evidenced. The findings are being discussed and compared with the effect of noradrenaline and adrenaline.

Drug Combinations↗
PubMed1975

[Determination of cardiac output using impedance-cardiography in comparison with conventional methods during rest and under pharmacological stress].

A recording of the changes in the transthoracic resistance as a function of the cardiac cycle enables--in connection with the ejection time--a non-invasive determination of the cardiac output (impedance cardiography). On volunteers without heart diseases the cardiac output according to the Fick principle, the impedance-cardiographic and sphygmographic method at rest and under pharmacological influence is synchronously measured and statistically compared with the found cardiac output according to Fick. Especially under pharmacological influence the impedance-cardiographically determined values do not show a sufficient correlation. The range of error, is causes as well as the limited possibility of application of the method are being discussed.

Cardiac Output↗