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Biomedical subjects

L Bengtsson

Publications and source records attributed to L Bengtsson.

45 records · Page 3Linked to original sources
PubMed1987

Preservation of myocardial high-energy phosphates in open-heart surgery with deep general hypothermia and multidose crystalloid cardioplegia.

Myocardial energy metabolism during deep general hypothermia (20 degrees C) and multidose crystalloid cardioplegia, and also during subsequent reperfusion, was studied in eight patients undergoing isolated aortic valve replacement. Six serial transmural biopsy samples from the left ventricular apex were analyzed for high-energy phosphates and their degradation products. Reductions in ATP, total adenine nucleotide content and energy charge were insignificant during cardioplegia, as were changes in adenosine and uric acid concentrations. During reperfusion, however, there was slight but significant reduction in total adenine nucleotide content, despite adequate oxygenation as indicated by reversal of lactate accumulation. These observations suggest that the reperfusion phase is accompanied by metabolic aberrations which are not overcome by good oxygenation in relation to the metabolic rate.

Adenine Nucleotides↗
PubMed1986

Thrombendarterectomy in chronic pulmonary embolism. Reports of 3 cases.

Thrombendarterectomy of the pulmonary artery was performed in three cases of chronic pulmonary embolism with pulmonary hypertension and right heart failure. The indications for such tissue-preserving surgery are discussed against the background of the presented cases and of the literature. These indications are unilateral vascular obstruction with good run-off in combination with "moderate" pulmonary hypertension. Patients with peripheral vascular changes in both lungs and equilibrated pressures respond poorly to thrombendarterectomy and present high surgical risk. For such patients hope lies in future resources for combined heart-lung transplantation.

Adult↗
PubMed1984

Anesthetic agents and sympatho-adrenal response to hemorrhage in the rat.

The sympatho-adrenal activity as reflected in plasma catecholamine levels was studied in rats subjected to a standardized hemorrhage. A comparison was performed between awake rats and rats anesthetized with diethylether, enflurane, barbiturate or ketamine. As expected diethylether increased sympathoadrenal activity. Enflurane induction increased adrenaline and decreased noradrenaline levels. Upon hemorrhage the sympatho-adrenal activity was depressed compared to the awake state. Barbiturate anesthesia depressed sympatho-adrenal activity. Ketamine increased noradrenaline levels and a relative hypertension was noticed during bleeding. The results focus attention on important differences in sympatho-adrenal activity between awake rats and rats anesthetized with different agents.

Anesthetics↗
PubMed1981

Dopamine infusion in man. Plasma catecholamine levels and pharmacokinetics.

Dopamine is widely used in the treatment of hypotensive conditions and/or impending renal failure, but the plasma levels of dopamine and other catecholamines in association with dopamine infusion are not known. Plasma catecholamines and dopamine pharmacokinetics during and after dopamine infusion were therefore studied in man. Two and 5 micrograms x kg-1 x min-1 of dopamine were infused for 30 min in two groups of five patients. Dose-dependent mean steady state levels with fairly large interindividual variations were reached within 5 min. Elimination of dopamine from plasma after termination of infusion had a biphasic course with t 1/2 alpha around 1 min and t 1/2 beta about 9 min in both groups. Noradrenaline plasma levels and blood pressure increased significantly in the 5 micrograms group. It is suggested that the vasoconstriction with deleterious effects on tissue perfusion, seen in conjunction with high-dose dopamine infusion, may be due to increased noradrenaline levels.

Adult↗
PubMed1980

Carcinoma of the gallbladder. Its relation to cholelithiasis and to the concept of prophylactic cholecystectomy.

Two hundred and thirteen cases of carcinoma of the gallbladder are reviewed with special reference to the presence or absence of symptoms of cholelithiasis. The majority of the patients (58%) had no history of cholelithiasis. Only one patient out of ten (11%) had gallstones known to have existed for more than a year, and the rest of the patients had a short history. A marked decrease in the cholecystectomy rate did not seem to affect the incidence of carcinoma over a period of eight years (1969--1976). Therefore cholecystectomy as prophylaxis against carcinoma does not seem to be justified. The only way to improve the prognosis of carcinoma of the gallbladder is to reduce the time between the onset of symptoms and surgery. The relative risk of carcinoma is ten times greater than symptoms and signs of cholecystitis are recorded and increases markedly beyond the age of sixty. Early surgery in these groups is recommended.

Aged↗
PubMed1980

Biliary carcinoma associated with methyldopa therapy.

In a retrospective study of 82 patients with biliary carcinoma a higher than expected prevalence of methyldopa therapy was found. Carcinogenesis by electrophile reactive metabolites of methyldopa is discussed.

Adult↗
PubMed1978

The incidence of carcinoma of the gallbladder and bile ducts in Sweden 1958 to 1972.

Between 1958 and 1972, 5913 carcinomas of the gallbladder and bile ducts were diagnosed in Sweden. These patients were divided into three groups, each covering a five year interval. The mean incidence was calculated for each group and related to age and sex. During the fifteen years of study a marked increase in the incidence was found, especially in elderly women.

Adult↗