A global association function is proposed that characterizes the apparent overall equilibrium of drug protein binding. It is defined as a function of the total drug concentration and may be directly calculated from each experimental result. The binding transfer function represents the relative rates of change in the bound and free concentrations from the total concentration. Two applications are presented: one is an investigation of the effect of temperature on binding of salicylic acid to proteins in plasma; and the other is a comparison of the phenomenon in two different biological fluids (protein binding of sodium salicylate in plasma and in synovial fluid).

Blood Proteins↗

PubMed1985

[Conception of a program for the treatment and statistical interrogation of data, LOGIST].

This paper presents a general program which cannot only be used for the treatment and the statistical interrogations, but also for basic operations, such as the validity check and the preparation of data which is often necessary for other programs. Its use of language is simple, suitable and accessible to non-specialists. The program is sufficiently complete so that it can treat some complex problems without requiring complementary programs. It can treat several problems simultaneously. This allows one to gain data-reading time and the program is therefore economical. Its domain of use is large: epidemiological studies, psychological and sociological investigations, biological studies, clinical research, chronological follow-up, examinations of faculties, . . . . The program is written in FORTRAN IV and thus transferable. It contains more than 25 000 instructions but needs limited place in the core memory (less than 64 000 words). Its structure allows further evolution and addition of new procedures or new methods. A transformation into a conversational form is considered.

Computers↗

PubMed1984

[The microcomputer in bacteriology. Value in the automated performance of antibiograms in hospitals].

In microbiology, most computerization is carried out by means of important centralized computers. On the contrary, our work is based upon the use of inexpensive microcomputers. We have developed general programs for the acquisition of data, their correction, and retrieval of lists arranged according to desired parameters (hospital department, germ, or sample) and various statistics, especially with respect to germ sensitivity. This system has been used on a routine basis since April 1982 in the Bacteriology Laboratory of Nancy University Hospital. It could easily be adapted to other laboratories and could provide a wide range of essential epidemiological data on the resistance of bacterial strains to antibiotics and their evolution with time.

Computers↗

PubMed1983

[Method of file sorting for mini- and microcomputers].

The authors describe a new sorting method of files which belongs to the class of direct-addressing sorting methods. It makes use of a variant of the classical technique of 'virtual memory'. It is particularly well suited to mini- and micro-computers which have a small core memory (32 K words, for example) and are fitted with a direct-access peripheral device, such as a disc unit. When the file to be sorted is medium-sized (some thousand records), the running of the program essentially occurs inside the core memory and consequently, the method becomes very fast. This is very important because most medical files handled in our laboratory are in this category. However, the method is also suitable for big computers and large files; its implementation is easy. It does not require any magnetic tape unit, and it seems to us to be one of the fastest methods available.

Computers↗

PubMed1982

Comparison of gingival index and sulcus bleeding index as indicators of periodontal status.

Although the gingival index and sulcus bleeding index have been widely used as indicators of periodontal status, there is some disagreement among investigators as to their meaning and significance. A clinical study was undertaken to monitor the occurrence of gingival bleeding, oedema, and change in colour in subjects with and without periodontal disease, and it was found that the combinations of these clinical symptoms often did not correspond exactly with an index score. It is therefore suggested that any study of periodontal disease should be based on fundamental criteria, such as bleeding or oedema, rather than on composite indices.

Adult↗

PubMed1979

[Research method using discriminant subsets on minicomputers].

Given a set of elements (illnesses, medicines,...) characterised by criteria or attributes (symptoms, characteristics, colour,...), each able to assume a certain number of states (for colour, more than nine), the problem is to find a minimal discriminant chain, or in other words, the smallest sequence of criteria enabling one to distinguish the elements of the initial set, unless of course they are identical. This problem is very general, but when tackled together it often involves excessive calculations. Based on the research principles proposed by Begon and Tremolieres, the authors propose a method well adapted to criteria in several states, which can be used on a small computer, when searching for pseudo-minimal chains by sampling. An application of this method (in liaison with the 'Centre Anti-Poisons', Nancy Pr Larcan) has enabled us to carry out a search for discriminant chains for more than 2800 medical tablets by their external characteristics, among which 3 quantitative criteria were known with a certain margin of error, and 21 qualitative criteria, making a total of more than 60 different states.

Computers↗

PubMed1979

[About the different steps leading to the quality of medical informations (importance of medical computing (author's transl)].

To draw the best conclusions from a set of medical data, one must first choose correct, valid, representative and well-expressed information. So it's not sufficient to collect data, but we have to valid them before including them in the records. After having put out the general characteristics of any validation and defined the fields where they can be applied we recommend a method over three steps. First, the physician alone, then the physician with an informatician and again the physician seem concerned by the steps of control. It is particularly important to develop the validation of chronology and generally speaking of evolutive data. Of course, the costs of validation with respect to the large groups of data must be taken into account.

Computers↗

PubMedDate not supplied

[About the different steps leading to the quality of medical information (importance of medical computing) (author's transl)].

Chronology as Topic↗

PubMedDate not supplied

[Tooth by tooth epidemiological study of caries in 3,400 children].

The DMF index distribution and the D, M, and F distributions on the whole teeth were described from a representative sample including 3,400 children at ages 6, 9 and 12. Results showed a great symetry for dental caries on each side of the median sagittal plane. The main spots of dental attack were found and the importance of each tooth in the determination of various indexes was analyzed. At each age, the first permanent molars are the most atracked. Many children have three or four decayed molars. Concerning the eruption of permanent teeth and the loss of primary teeth, we found the same symetry of these events between upper and lower maxillar as well as from on side of the median sagittal plane to the other.

Child↗

PubMedDate not supplied

[Development of medical studies from high school to the thesis].

Explore the source record for details and available documents.

Adolescent↗