Thymic involution and HIV progression.
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Biomedical subjects
Publications and source records attributed to L Beltz.
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Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for Gag, Pol, and Env, compared with levels present in intermediate and advanced progressors. CD8+ memory cytotoxic T lymphocytes may have an important role in controlling HIV-1 replication and preventing disease in long-term nonprogressors.
The compression of the neurovascular bundle of the upper limb (thoracic outlet syndrome, TOS) can be caused by osseous, muscular, fibrous, tumourous and habitual abnormalities of the cervicothoracic junction. Osseous causes can be shown in a conventional x-ray of the cervicothoracic junction. In about 40% of the cases there is a venous stenosis which can be proved by means of phlebography in a special patient position (provocation position). The type of stenosis and location provides information on the cause of it. We examined 34 patients.
Rhesus progenitor-enriched BM was exposed overnight to SIV and cultured in a limiting dilution assay where the potential for progenitor interaction with lymphocytes or macrophages was low. Virus was consistently isolated late in culture, detection being aided by coculture with CEM174 lymphoblasts. Although infected cells had reduced clonogenic activity, colonies were indistinguishable from those derived from uninfected BM with respect to proliferative potential, morphology, and longevity in culture. Primate immunodeficiency viruses, therefore, may infect immature BM populations, directly affecting hematopoietic activity.
This report deals with two cases of a spontaneous perirenal hematoma. In the first case the spontaneous perirenal hematoma resulted from hemorrhages from the vessels of the stratum fibrovasculare of the renal capsule. This bleedings led to the development of a granulation tissue which in turn is rich in small blood vessels. Due to the lytic activities of this granulation tissue the hematomas became resorbed and finally are transformed into a big pseudocyst which surrounds the lower half of the kidney. On the other hand the new-built vessels of the granulation tissue are the source of further bleedings thereby perpetuating the process. In the second case the perirenal hematoma resulted from two aneurysms of the renal artery. In both cases clinical and radiological investigations had been unable to demonstrate the lesion.
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13 of 30 patients suffering from pseudo-LE-syndrome showed a usually reversible enlargement of the heart during the acute stage of the disease. In two patients carditis occurring in pseudo-LE-syndrome lead to congestive heart failure and an additional patient died in the acute stage of carditis. As opposed to Systemic Lupus Erythematosus hypertension did not occur in a higher frequency than normal. In five cases cardiac catheter examinations showed slight elevation of the end-diastolic pressure in the right ventricle, in two cases an abnormal high mean pressure in the right atrium and a systolic gradient at the pulmonic valve was found. -Scintigrams showed definite enlargement of the spleen and to a lesser degree enlargement of the liver was seen. Laparascopy showed multiple concretions after peritonitis. Lymphographic changes in the retroperitoneal lymph nodes and lymphatic ducts were not observed in contrast to rheumatic diseases. Drug histories in most cases discovered intake of Venopyronum dragees prior to onset of the disease. But recurrent attacks of the disease also occurred without further intake of the drug.
Two patients with anomalous origin of the left coronary artery from the pulmonary artery are presented. Anatomy, embryology, the problem of the direction of blood flow in the anomalous vessel, and the clinical symptoms of this syndrome are discussed. In spite of large fibrotic areas in the myocardium, the ECG-changes were minimal. Therefore, a nearly normal ECG does not exclude this anomaly. In patients with sudden, unexpected death one should suspect an anomalous origin of a coronary artery. The classification in an "infantile" and "adult" type reflects the extent to which collateral vessels have developed. Ligation of the anomalous coronary artery at the side of its origin with concomitant aorto-coronary bypass appears to be a rational and the only effective way of therapy.
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