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Biomedical subjects

L Bellodi

Publications and source records attributed to L Bellodi.

At least 127 records · Page 7Linked to original sources
PubMed1986

Genetic modelling in schizophrenia according to HLA typing.

Studying families of schizophrenic patients, we observed that the risk of developing the overt form of the illness could be enhanced by some factors. Among these various factors we focused our attention on a biological variable, namely the presence or the absence of particular HLA antigens: partitioning our schizophrenic patients according to their HLA structure (i.e. those with HLA-A1 or CRAG-A1 antigens and those with HLA-non-CRAG-A1 antigens, respectively), revealed different illness distribution in the two groups. From a genetic point of view, this finding suggests the presence of heterogeneity in the hypothetical liability system related to schizophrenia and we evaluated the heterogeneity hypothesis by applying alternative genetic models to our data, trying to detect more biologically homogeneous subgroups of the disease.

Adolescent↗
PubMed1986

[The significance of antipolysaccharide C antibodies from Streptococcus group A. Their importance in the diagnosis of streptococcal infections].

Here is underlined the role of quantitative determination of streptococcus A polysaccharide C antibody for the diagnosis of streptococcal infection. The Authors suggest to associate this determination with antistreptolysin titer and/or bacterial esoenzyme antibody titer, in order to achieve a wider spectrum of streptococcus induced antibodies for therapeutic and prophylactic applications.

Antibodies, Bacterial↗
PubMed1985

Effect of HLA type on age at onset in schizophrenic disorders.

In a sample of 229 patients affected by schizophrenic disorders according to DSM-III, the authors tested the effect of the HLA type, sex and severity of the disease with respect to the distribution of age at onset. All the three factors reached, independently, a statistically significant value: that is, HLA A1 positive males affected by the severe form of the illness show the earliest breakdown of the disease. This finding partially confirms previous results, and particularly the importance of the HLA influence is discussed.

Adolescent↗
PubMed1981

Possible linkage between primary affective disorder susceptibility locus and HLA haplotypes.

The authors analyzed the concordance of sib pairs of HLA typing in cases where both sibs had affective illness and where the sibs were discordant. They detected an excess of HLA similarities in doubly affected sibs and a lack of similarities in discordant sibs. Therefore, the authors hypothesize that HLA may be linked with a primary affective disorder susceptibility locus or it may be associated with such a locus in some other way.

Disease Susceptibility↗
PubMed1978

HLA typing and affective disorders: a study in the Italian population.

HLA phenotype distribution was investigated in 91 affective patients. Significant increases over those of the control population were found in HLA-A 29 and in Bw 22 frequencies, while A 10 and A 30 were decreased. No significant difference was shown between the two clinical subgroups (41 unipolar patients and 50 bipolar ones). On comparing our data with those from other authors, Bw 16 was significantly increased. However, a high degree of heterogeneity was also shown for this antigen. Of some interest is the finding that relapsed and non-relapsed patients during long-term lithium therapy display diverging HLA phenotype distributions, with B 5 increased among the non-relapsed subjects.

Bipolar Disorder↗
PubMed1977

Histocompatibility antigens and effects of neuroactive drugs on phytohaemagglutinin stimulation of lymphocytes in vitro.

The effects of a psychopharmacological agent, sulpiride, and of some neuromediators, dopamine, norepinephrine and propranolol, on the uptake of 3H-thymidine by lymphocytes stimulated in vitro with phytohaemagglutinin (PHA) were studied. The lymphoctes were obtained from two populations of subjects, one with HLA-AL CRAG antigens of the HLA-SD series and one without. We found that the presence of the CRAG antigens in the lymphocytes led in the presence of the various drugs to behaviour different from what was seen when the antigens were not present. When the two groups were pooled, PHA lymphocytes activation was inhibited by dopamine, sulpiride, and propranolol and was not effected by norepinephrine.

Cross Reactions↗
PubMed1976

HLA-SD antigens and schizophrenia: statistical and genetical considerations.

The HLA-SD phenotype distributions of hebephrenic and paranoid schizophrenics, and of the two groups combined, in an Italian population and in a combined group from the Swedish population have been analyzed statistically. There is a significantly decreased frequency of HLA-A10 in all of these. Theae are some preliminary indications of an increased frequency (a positive association) for some of the other antigens of the HLA-SD series, but there is insufficient data at present for evaluating the significance of these findings. Differences between hebephrenic and paranoid schizophrenics have been detected.

Diagnosis, Differential↗
PubMed1976

MHPG, amitriptyline and affective disorders. A longitudinal study.

The daily urinary excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) were studied longitudinally in five unipolar depressed patients. The patients were followed first during a pretreatment period, and then during a treatment period in which amitriptyline was administered. The data we have obtained suggest that: (1) there is a wide individual variability in MHPG pretreatment levels: (2) amitriptyline modifies MHPG levels in a way which seems to be related to the pretreatment MHPG; (3) amitriptyline may produce a sustained improvement in depressive symptoms, independent of the pretreatment MHPG values, and (4) the time course of modifications in MHPG excretion is shorter than the time course of improvement in depression. Some theoretical implication of these findings are discussed in terms of the catecholamine hypothesis of affective disorders.

Adult↗
PubMed1976

The HLA system and the clinical response to treatment with chlorpromazine.

A group of 33 schizophrenic patients were typed for HLA-SD antigens and their qualitative clinical responses to chlorpromazine therapy determined. A highly significant positive correlation was found between response to chlorpromazine and HLA-AI positive, while HLA-A2 positive subjects showed a significant negative correlation to chlorpromazine treatment. In a second group of 17 patients the clinical response to chlorpromazine were evaluated quantitatively, by WPRS, in HLA-AI positive and HLA-AI negative patients. There were no pre-treatment differences in the scores. After treatment the scores of positive patients were significantly lower, indicating that they responded to a greater degree. Since the frequency of HLA-AI in hebephrenic patients is higher than that in other schizophrenics this may explain our earlier finding that hebephrenics, as a group, respond better to chlorpromazine than do other schizophrenics.

Anxiety↗