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Biomedical subjects

L Bello

Publications and source records attributed to L Bello.

41 records · Page 3Linked to original sources
PubMedDate not supplied

Urinary epidermal growth factor (EGF) levels and epidermal growth factor receptor (EGF-R) expression in human cerebral tumors. Clinical considerations.

The levels of Epidermal Growth Factor (EGF) in urine samples collected from 58 patients (22 low grade gliomas, 13 anaplastic gliomas, 15 glioblastomas and 8 meningiomas) with cerebral tumors admitted at our Institute during 1994 were determined. EGF levels were measured by a specific RIA method. A preoperative and one or two postoperative determinations were performed. Further samples were collected before and at three weeks after postoperative radiotherapy and/or chemotherapy. EGF-Receptor (EGF-R) was determined by an immunohistochemical method on specimens of the same tumor. Preoperative levels showed a positive correlation with the degree of tumor anaplasia. A decrease of the postoperative levels of EGF was observed in all patients who underwent surgery and the entity of the decrease seemed to be well correlated with the extent of the tumoral resection. A strict correlation between EGF levels fluctuations and clinical and neuroradiological features was documented in patients submitted to radiotherapy and/or chemotherapy. The preliminary results on EGF-R expression suggest the existence of a correlation between EGF levels and the receptor expression. In 4 cases of glioblastoma low preoperative levels were associated to an high receptor expression in 2 cases while in the remainder the receptor was not detectable. An high receptor expression is pathognomonic of meningiomatous tissue, even if is not correlated to the biological behaviour and histological features of the neoplasia. These preliminary data suggest the reliability of EGF levels/EGF-R determination in the diagnosis and follow-up of patients with cerebral tumors particularly for those of glial origin. Our data confirmed the role of the EGF system in the development and growth of human gliomas and meningiomas.

Adult↗
PubMedDate not supplied

Early postoperative seizures and endovenous phenytoin. Preliminary clinical data.

Early seizures represent a major complication in the post operative course of patients operated on for supratentorial tumors or AVMs. The real effectiveness of the AEDs prophylaxis to reduce the occurrence of post operative seizures is controversial. We proposed a prophylactic treatment with endovenous PHT consisting of two infusions of PHT (mean dosage of 18 mg/kg; mean time of 1 hr) perioperatively and during the first postoperative day. The interruption of the previous oral anticonvulsant treatment is not required. The endovenous route should permit a rapid reach of the therapeutical range. Sixty-six patients were treated. Fifty-one patients received two infusions and 15 patients only one infusion. The serum concentration of PHT performed at 24 hrs of operation was in most of patients (more than 80%) in the lower part of the therapeutical range while at 24 hrs of the second infusion was in the higher part or over the range. The overall prevalence of seizures was 10.6%. In the first group the incidence was 7.8%, in the second one was 20%. All the seizures appeared within 48 hrs of the operation. All the patients in the first group had single seizures, 2 patients of the second one experienced two seizures. No status epilepticus was observed. Alteration of consciousness and mild hypotension were the most common side effects. They never required major measurements and were mild, transient and completely reversible. We are starting with a randomized study based on a larger sample of patients which will allow a more reliable statistical analysis.

Adolescent↗