Search PubMed⌕ Search

Biomedical subjects

L Belin

Publications and source records attributed to L Belin.

At least 55 records · Page 3Linked to original sources
PubMed1984

Immunotherapy with alginate-conjugated and alum-precipitated grass pollen extracts in patients with allergic rhinoconjunctivitis.

In order to compare the safety and the efficacy of two grass pollen extracts made from the same starting material, i.e. equal proportions of cocksfoot and timothy, a 3-year study was made on patients with hay fever. One product was a dialysed aqueous extract of pollens which was chemically conjugated to activated sodium alginate ( Conjuvac ). The other was a pyridine-extracted alum-precipitated crude extract (Allpyral). Forty patients with classical hay fever were admitted to the study. All gave positive result to prick and nasal/conjunctival testing with extracts of both cocksfoot and timothy grass. Thirty-five patients completed all 3 years of the study. Seventeen/eighteen Allpyral-treated and 17/17 Conjuvac -treated patients were subjectively improved. There was no significant difference in symptom scores between the two groups. Challenge tests showed a tendency to reduced sensitivity to allergen in the Conjuvac -treated but not in the Allpyral-treated group. The median values for specific IgG and IgE showed the same pattern of reaction as seen in earlier studies of pollen hyposensitization. There was, however, a greater increase of grass-specific IgG in the Conjuvac -treated patients. No serious adverse effects were seen in any of the treatment groups, but there were slightly fewer side effects in the Conjuvac group.

Adolescent↗
PubMed1983

Amines: possible causative agents in the development of bronchial hyperreactivity in workers manufacturing polyurethanes from isocyanates.

Investigations of respiratory symptoms among workers in a factory producing polyurethane foam included measurement of air pollution with amines and isocyanates and a simultaneous health investigation of the exposed workers. An increased bronchial reactivity to inhaled methacholine was found in the study group compared with two unexposed control groups. This finding, together with visual disturbances in the exposed group, were assumed to be caused mainly by the volatile amines. The concentrations of isocyanates in air were well below 0.005 ppm. The amine concentration was 1000 to 10 000 times higher than the isocyanate concentration. The most volatile amine, N-methylmorpholine, occurred in the air in concentrations higher than 10 ppm. The results indicate that not only the isocyanates but also the amines might well be responsible for respiratory symptoms among exposed workers in polyurethane foam production.

Adult↗
PubMed1983

Is mild byssinosis associated with small airways disease?

Attempts were made to determine if, in the mild stage of byssinosis, there are changes located to small airways and if bronchial reactivity is increased. Twenty-two cotton workers from two cotton mills outside Gothenburg were studied, 6 non-smokers without a history of byssinosis and 16 mild byssinotics, 10 of whom were smokers. They were examined before a Monday shift and then re-examined after another Monday shift, one or two weeks later. Spirometry, lung volumes, the single-breath nitrogen wash-out test and the maximum expiratory flows after air and helium-oxygen breathing were obtained. The bronchial reactivity to methacholine was also assessed before and after shift. We found no indication of deteriorated test values in the non-smoking group regardless of symptoms of byssinosis. However, the reactivity to methacholine was clearly increased compared to a control group. We conclude that changes of small airways are probably not characteristic for mild byssinosis and therefore probably not the predominant location of byssinotic lung changes.

Acute Disease↗
PubMed1981

Evaluation of circulating immune complex-like material for development of skin reactions in connection with penicillin therapy.

The levels of immune complex-like material in serum from 18 patients in connection with skin eruptions appearing during penicillin therapy were determined with a modified ELISA. Immune complex-like material could only be shown in the serum of 3 out of the 17 patients. However, according to ELISA results, the complexes appeared without the simultaneous presence of penicilloyl-specific antibodies. Neither could penicilloyl-specific antibodies be recorded in 9 patient treated with parenteral penicillin without adverse reactions. 3 of these patients had immune complex-like material in their serum. It was concluded that immune complex-like material with penicilloyl specificity is not likely to contribute to the development of skin eruptions often seen in connection with penicillin treatment.

Adolescent↗
PubMed1980

Introduction.

Explore the source record for details and available documents.

Adult↗
PubMed1977

Studies on humans exposed to airborne sewage sludge.

A clinical investigation was made among workers in a sewage treatment plant and age matched controls not exposed to sewage. Acute incidences of fever and eye symptoms were found in about 50% of the exposed population. Serum immunoglobulins, white blood cells and thrombocytes were elevated in the exposed group. A higher percentage of increased levels of C-reactive protein and fibrinogen degradation products was found in the exposed group. Although no definite cause-effect relationship can be established the responsible agent in the environment could well be endotoxins.

Air Pollution↗
PubMed1976

Diagnosis of reaginic allergy with house dust, animal dander and pollen allergens in adult patients. I. A comparison between RAST, skin tests and provocation tests.

RAST analyses were performed with house dust, animal dander and eleven pollen allergens in 410 adult patients with asthma and/or rhinitis and the findings were compared with skin test and provocation test results. The overall correlation between 1,316 provocation tests and RAST was 78% and the correlation between 1,778 skin tests and RAST was 66%. The relationships between RAST and in vivo tests differed considerably from allergen to allergen. No significant differences were found between various age groups. According to the in vivo tests the RAST showed more often positive results in patients with pronounced allergy than in patients with low-grade allergy. Higher RAST classes were most often combined with positive in vivo tests. It is concluded that in cases with RAST classes 2-4, a reasonably well-established allergy diagnosis can be reached without the inclusion of additional in vivo tests. In other cases, however, application of further diagnostic methods is required.

Adolescent↗
PubMed1975

Quantity and avidity of antibodies against birch pollen in atopic patients during hyposensitization. A preliminary study.

The degree and strength of the binding of radioactively labelled allergen by antibodies in the sera of birch pollen-sensitive individuals was studied during the course of hyposensitization with alun-precipitated aqueous-pyridine extracted birch pollen antigens using the ammonium-sulphate precipitation technique originally described by FARR. The allergen binding was measured before and after absorption of the sera with anti-human IgE antibodies conjugated to Sepharose. It was noted that IgE antibodies of low avidity caused clinical sensitivity as well as IgE antibodies of higher avidity. The nasal sensitivity to birch pollen allergen of six of the seven patients studied significantly decreased by the treatment without any quite uniform change of serum-binding capacity for the allergen. Thus the clinical improvement was accompanied either by disappearance of the specific IgE antibodies, concomitant with formation of antigen-binding non-IgE antibodies, or by increased formation of IgE antibodies with very slight contribution by non-IgE antibodies to the totally increased antigen-binding efficiency. It is felt that the serological antibody changes may not reflect the most relevant immunological events during successful hyposensitization therapy.

Adolescent↗