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Biomedical subjects

L Beckman

Publications and source records attributed to L Beckman.

At least 127 records · Page 7Linked to original sources
PubMed1977

Congenital dislocation of the hip joint in northern Sweden.

The incidence of neonatally diagnosed congeital dislocation of the hip joint (CDH) was found to vary between three hospitals in Northern Seden. The incidence was 10.0, 7.1 and 3.5 per thousand in hospitals A, B and C, repectively. The incidence increased during the period 1960-73 in hospitals A and B, but not in hospital C. At these hospitals the number of cases needing prolonged orthopaedic treatment showed an inverse relationship to the incidence of neonatally diagnosed CDH.

Female↗
PubMed1977

Population studies in northern Sweden. VIII. Ethnic heterogeneity and prenatal selection in the esterase D polymorphism.

The esterase D polymorphism was studied in samples of red cells from different populations and in extracts of chorionic tissue from abortuses and placentae at term. No frequency differences were found between Finns, Lapps, and Swedes. The high frequency of the ES D2 gene previously observed among Lapps was not confirmed in this study. The distribution of ES D phenotypes was very similar in spontaneously aborted fetuses, newborns and adults, hence there was no evidence for prenatal selection operating in this polymorphism.

Adult↗
PubMed1977

Red cell enzyme types in psoriasis.

Seven red cell enzyme systems were examined for electrophoretic variation in a series of psoriatic patients. In two polymorphic (ADA, ES D) and four non-polymorphic systems (SOD, MDH, LDH, Dia) no deviations from normal controls were found. In the acid phosphatase system the frequency of the pa gene was found to be decreased.

Acid Phosphatase↗
PubMed1977

Chromosome aberrations in workers exposed to arsenic.

The occurrence of chromosome aberrations was studied in short-term cultured lymphocytes from nine workers exposed to arsenic at the Rönnskär smeltery in northern Sweden. In the smelter workers, 87 aberrations were found in 819 mitoses. The number of aberrations varied individually from 0 to 25 aberrations per 100 cells. In a control material 13 aberrations were found in 1012 mitoses. The frequency of chromosome aberrations was significantly increased among the smelter workers, but due to the simultaneous exposure to other agents the effect of arsenic per se can not be assessed with certainty.

Arsenic Poisoning↗
PubMed1977

Genetic markers in psoriasis. Correlations to age at onset, continuity of symptoms and the risk of developing the disease.

In a study on genetic markers (22 HLA antigens, 6 blood group types, 3 serum groups and 3 red cell enzymes) in psoriatic patients the following statistically significant differences were found between patients and controls: 1) The HLA factors B13 and Bw17, the Lewis blood group Le(a-b-) and the blood group factor A were overrepresented among the patients. A decrease in the frequencies of the HLA factors B7 and B8 was noted, confirming several similar findings by other investigators. 2) In the Ss (MNSs), C3 and haptoglobin (Hp) systems the psoriatic patients showed a decreased frequency of heterozygotes. 3) Among patients with continuous symptoms the blood group factor A and the blood group Fy (a+b-) were overrepresented. 4) Patients with late onset of psoriasis showed an increase in the blood group (Fy(a+bb-) and a decrease in the haptoglobin type 2-2. Relative risk figures have been calculated for different phenotypes. Certain genetic combinations were found to be grossly overrepresented among the patients. The mechanisms behind the associations appear to differ. In three systems (Ss, C3 and Hp) the deviations in psoriatic patients suggest the presence of heterozygote advantage.

Adolescent↗
PubMed1977

Increased serum levels of the pregnancy zone protein in psoriasis.

On the basis of immunological studies on psoriasis in recent years, it seems probable that immunological mechanisms are of importance and that psoriasis could be regarded as an immunogenetic disease. In this study, increased serum levels of an immunosuppressive factor, the pregnancy zone protein (PZ), were found in psoriatic patients. Patients with elevated levels (greater than 2 S.D. units) of PZ showed a positive association with continuous symptoms and a negative association with blood groups A and Fy(a+b-). Thus, induction of PZ occurs mainly in psoriatic patients who have a particular genetic constitution. The results support the hypothesis that PZ is not only an immunosuppressive but also an immunoreactive protein.

Adolescent↗
PubMed1976

Serum naphythylamidase isoenzymes during hormonal treatment. Electrophoretic and quantitative studies.

Alterations in serum naphthylamidase isoenzymes were studied by electrophoretic and quantitative methods in women treated with oral contraceptives and women treated with naturally occurring conjugated estrogens for climacteric symptoms. In women treated with oral contraceptives the appearance of extra isoenzyme components was accompanied by a distinct and significant increase in the total serum naphthylamidase activity, whereas in treatment with conjugated estrogens no such increase was found. The result suggests that combined oral contraceptives and natural estrogens affect the serum naphthylamidase pattern in different ways.

Adult↗
PubMed1975

Phosphoglucomutase phenotypes and prenatal selection. Studies of spontaneous and induced abortions.

The PGM1 and PGM3 phenotypes were examined in extracts of chorionic tissue from 97 spontaneous and 266 induced abortions. Contamination by maternal tissue or blood cells was shown to be insignificant. A positive association was found between the PGM11 and PGM13 genes. No significant differences in phenotype distributions were found between the population of spontaneously aborted fetuses and the normal fetal or adult populations. Hence it was concluded that there is no evidence so far for prenatal selection operating in the PGM1 and PGM3 polymorphisms.

Abortion, Induced↗