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Biomedical subjects

L Bariani

Publications and source records attributed to L Bariani.

33 records · Page 2Linked to original sources
PubMed1983

[Migration of hepatic macrophages after cyclophosphamide or whole body irradiation].

The liver macrophages behaviour after cyclophosphamide or total-body irradiation (1000 rads - 60Co) has been studied in the mouse previously injected with colloidal carbon. In these conditions an early increase of carbon-laden macrophages in the central zone of the liver lobules has been observed. Carbon-containing mononuclear cells were also observed in the lumina of the hepatic collecting system. Possible implications of these findings are discussed; a migration of macrophages from the liver to elsewhere is suggested.

Animals↗
PubMed1982

[Effect of antiblastic polychemotherapy (CMF) on the number of circulating monocytes in patients with breast cancer].

The behaviour of the number of circulating monocytes has been studied in 34 patients suffering from breast cancer and subjected to antiblastic polychemotherapy in accordance with the CMF pattern. In 25 patients the absolute number of monocytes fell after treatment, while in 9 it rose. The percentage of monocytopenic patients rose from 29% to 50% of the total series. The pathogenetic mechanisms of this behaviour are discussed and it is emphasized that antiblastic treatment with cytostatic drugs can be included among the causes of monocytopenia.

Adult↗
PubMed1978

[Phagocytic lymphocyte-like elements (PLLE) and irradiation in vitro].

The peripheral blood of rats contains lymphocyte-like phagocytes after intracardial injection of India ink. In vitro irradiation of whole blood (1000 r - 60Co), causes marked reduction in whole lymphocytes but does not modify the number and morphological integrity of the phagocytes, which can therefore be held to be comparatively radioresistant: as such, they could belong either to the mononucleate phagocyte system or to the lymphatic system (T4 lymphocytes). Since T-lymphocytes are not capable of phagocytosis, the former hypothesis would appear the most probable.

Animals↗
PubMedDate not supplied

Multiple chromosomal associations and paracentromeric region instability in a case of acute leukemia.

A case of acute myelomonocytic leukema is described, which was characterized cytogenetically by the presence of centromeric elongations, somatic crossovers, selective endoreduplication figures, and multiple chromosomal clusters. The demonstration of these phenomena by selective staining techniques for the chromosome bands (Q, C, G and S) and the nucleolar areas (acridine-orange, amido black B 10) raises some biological aspects involved in the proliferation of leukemic cells, such as nucleolar persistance during the metaphase and the non-separation of chromatids in the clusters during the anaphase. These structural abnormalities may represent the background for the explanation of the appearance of subclones in neoplastic disorders.

Adult↗
PubMedDate not supplied

Hypoparathyroidism in chronic alcohol intoxication: a preliminary report.

It is well known that osteoporosis is more common in chronic alcoholists than in age-matched controls. Possible aetiological factors could be: malabsorption of calcium and vitamin D, liver disease, abnormal parathyroid function. With this study, the authors investigated parathyroid hormone (PTH) behaviour in thirteen selected patients with alcohol abuse, free from any clinical or humoral sign of hepatopathy, and in ten healthy subjects as a control group. In alcohol abusers a significant reduction of plasmatic PTH, compared to normal calcium levels were found. A possible direct interaction effect between ethyl alcohol and PTH may be suggested, even if further studies are required.

Adult↗
PubMedDate not supplied

[A "plethora", minor and transient, as an immediate cause of a cerebrovascular accident].

Even if the well-known predisposing factors play an essential role in the realization of cerebrovascular accidents, in these last years the possible importance of the hemoreologic parameters is still a topic under discussion. The authors found a significant increase of the considered hemoreologic parameters (HT, Hb, RBC) in the patients hospitalized for cerebrovascular accidents compared to controls, without differences for gender, even if this increase remained into the limits of normal range. Conversely, no significant differences were found concerning the considered metabolic parameters.

Aged↗
PubMedDate not supplied

Acute sublingual nifedipine and adrenergic activation: a chronobiologic attempt of optimized administration in healthy subjects.

Nifedipine has been shown to increase heart rate and plasma catecholamines, due to an adrenergic activation. Two healthy male subjects, after a period of sinchronization, have self-measured heart rate (HR) every 30 min for two consecutive days through a portable, non invasive, automatic device. The data were then analysed by means of chronobiologic procedures, to verify their personal HR acrophase. Forty-eight hours later, the same subjects repeated the trial, assuming 20 mg of sublingual nifedipine just one hour before their calculated HR acrophase, and data were analysed at the same way. After drug assumption, both HR acrophases and mesors failed to show any modification.

Administration, Sublingual↗
PubMedDate not supplied

Temporal organization of cerebrovascular accidents: a retrospective, preliminary study about stroke in Ferrara, Italy.

An epidemiologic retrospective study was conducted from January 1984 to December 1988 on subjects admitted into the Institute of Semeiotica Medica of the University of Ferrara (as a general medicine, unselective department) and presenting a stroke. Year, month and hour of onset of symptoms in 141 patients (all resident in Ferrara, mean age 74.3 +/- 8.3 years) were carefully recorded. The definition of precise clock hour was reached only in 108 cases. The data were then analyzed by means of Halberg's single cosinor. Time series analysis showed a seasonal pattern of disease onset, characterized by a circannual rhythm with acrophase in late winter - early spring (-83.9 degrees). A significant circadian rhythm was found too, with acrophase at afternoon (-242.8 degrees).

Aged↗
PubMedDate not supplied

[Erythrocyte carbonic anhydrase in subjects on periodic hemodialysis].

Red cell carbonic anhydrase isoenzymes I and II have been measured by means of cellulose acetate membrane electrophoresis in patients with chronic renal failure and dependent on periodic hemodialysis; these patients showed a chronic anemia due to many factors. Carbonic anhydrase isoenzymes were higher in uremic and anemic patients than in the controls. Since hemoglobin can act as a protons acceptor from the active site of carbonic anhydrase during the hydratation of CO2 (and vice-versa), the increase of carbonic anhydrase can facilitate, via the Bohr effect, the transfer of the oxygen to the peripheral tissues. Therefore an increase of red cell carbonic anhydrase can constitute a compensating mechanism of anemic hypoxia in uremic patients.

Adult↗
PubMedDate not supplied

Erythroblastic islands in the bone marrow of rheumatoid arthritis with anaemia.

An increase of erythroblastic islands with recognizable central macrophages was observed in bone marrow of six rheumatoid arthritis (RA) patients suffering from anaemia. Since erythroblastic islands are more prominent in anaemic conditions associated with ineffective erythropoiesis, it is possible that this morphological finding might be an expression of the increased ineffective erythropoiesis observed in RA patients with anaemia.

Aged↗
PubMedDate not supplied

[The heterozygote beta-thalassemic patient with regard to radiological hazards].

Since anaemia of varying degree is a quite common finding in heterozygous beta-thalassaemia, a research was done to see if beta-thalassaemia heterozygotes occupationally exposed to long-term continuous external radiation should be more susceptible to haematopoietic damage than non thalassaemic subjects. We examined peripheral haematological findings of 20 beta-thalassaemia heterozygotes previously exposed to a mean of 10.7 mSv, compared with 22 non thalassaemic subjects exposed to 6 mSv, and with 50 not exposed beta-thalassaemia heterozygotes. The obtained results suggest that whole-body external irradiation--with the mean doses reported--does not cause noteworthy changes in beta-thalassaemia heterozygotes.

Adolescent↗