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Biomedical subjects

L Balus

Publications and source records attributed to L Balus.

36 records · Page 2Linked to original sources
PubMed1987

Subungual exostosis. Histological and clinical considerations on 30 cases.

The authors review 30 cases of subungual exostosis, 27 in the foot and 3 in the hand. In approximately 80% of the cases, errors in initial diagnosis had been made, and the affection had been confused with ordinary verrucae, mycoses or pyogenic disease. Histological examination showed that in some cases the neoformation ossified by an enchondral mechanism similar to that of osteocartilaginous exostosis, while more often the mechanism was of the intramembranous or mixed type. The treatment consisted of resection of the exostosis at its base after removing the nail. Complete healing occurred in all cases.

Adolescent↗
PubMed1986

Familial multiple trichodiscomas.

Two sisters developed multiple pure trichodiscomas. The report confirms the familial occurrence of these tumors recently described and analyzes some of their histologic and ultrastructural features.

Female↗
PubMed1985

Granulomatous slack skin.

A 39-year-old man had a two-year history of three indurated plaques that progressively underwent a cutis laxa-like transformation. Histopathologically a granulomatous, deep, dermal infiltrate was observed. It was composed mainly of numerous histiocytes and many multinucleate cells and foam cells. The case has the clinical and microscopic features of granulomatous slack skin (GSS), which may be considered to be a peculiar form of localized elastolysis. To date, there is no effective therapy for GSS.

Adult↗
PubMed1983

[Fibrofolliculoma, trichodiscoma and acrochordon. The Birt-Hogg-Dubé syndrome].

The Birt-Hogg-Dubé syndrome is characterized: a) clinically, by an asymptomatic eruption of dome-shaped papules involving the head, neck, chest, back and arms frequently associated with acrochordons; b) histologically, by multiple follicular tumors, namely fibrofolliculomas and trichodiscomas, representing benign proliferations of mesodermal and ectodermal components of the pilar apparatus; c) by the apparent autosomal dominant mode of inheritance. This study is concerned with two families whose various members belonging to two and three generations have the clinical and histological lesions of this syndrome. In several biopsies performed, the main finding was the fibrofolliculoma isolated or associated with perifollicular fibromas; in five biopsies, was noted a typical trichodiscoma associated, in two of them, with a perifollicular fibroma. Clinically, the fibrofolliculomas were indistinguishable from trichodiscomas. We believe that the Birt-Hogg-Dubé syndrome is an autonomous well individualized skin disease. Its existence supports the view of the close interaction between the epithelial and mesodermal components of the pilar complex.

Adult↗
PubMed1979

Effect of dicarboxylic acids on lentigo maligna.

Dicarboxylic acids from C8 to C14 are competitive inhibitors of tyrosinase in vitro, and here, the effect of a cream containing 15% azelaic acid (C9) on 3 cases of lentigo maligna is described. The lesions were treated for 90 days, with remarkable clinical and histological effect, maintained for up to 2 yr after cessation of treatment. Progress during treatment of one case was additionally monitored by electron microscopy, which revealed progressive elimination of abnormal melanocytes both basally and suprabasally, and their replacement by essentially normal cells engaged in normal melanogenesis. There was also progressive diminution in the general disorganization of the epidermis, and disappearance of lymphocyte response. It is concluded that dicarboxylic acids have a direct inhibitory and cytotoxic effect on abnormally active or structurally disordered melanocytes in lentigo maligna, but further investigations are required to establish their precise mode of action. Similar application of dicarboxylic acids to normal skin affects only a small proportion of melanocytes, suggesting that some phasic factor, or individual states of activity, may be concerned in their susceptibility.

Aged↗
PubMedDate not supplied

Macroscopic and microscopic characteristics of an African Blastomyces dermatitidis strain.

This report describes the macro- and microscopic characteristics of a strain of Blastomyces dermatitidis isolated in an Italian hospital from a Libyan patient suffering from cutaneous blastomycosis. The fungus was isolated with great difficulty because of the presence of a Proteus species on the lesion. Conversion of the mycelial into the yeast-like phase achieved the best results, using Columbia ANC culture medium. After 5-6 days, this transformation was only partial and presented swollen hyphae and yeast-like cells. The biological characteristics were typical of B. dermatitidis strains of African origin. The differences between African and North American strains are confirmed, in agreement with findings already reported in the literature.

Blastomyces↗
PubMedDate not supplied

[Verruciform xanthoma of the penis].

Verruciform xanthoma is a solitary verrucous lesion, usually occurring on the oral mucosa. It is characterized histologically by the presence of foam cells within elongated dermal papillae. Only few extra-oral case of V.X. have been reported. An unusual location of verruciform xanthoma of the penis is described.

Humans↗