Biomedical subjects

L Babić

Publications and source records attributed to L Babić.

At least 19 recordsLinked to original sources

PubMed1996

[Case report of a rare cause of hypopituitarism].

Hypopituitarism is an illness of the hypophysis with deficit of one or more pituitary hormones. It can be congenital or acquired. Etiologic factors of acquired hypophyseal insufficiency are numerous. Pituitary gland infarction is a frequent cause of hypopituitarism. Extracorporeal circulation, applied in cardiac surgery procedures, may also, by mechanism of ischemic necrosis, cause hypophyseal lesions and development of hypopituitarism. This paper presents a case of a female patient suffering from panhypopituitarism which developed after extracorporeal circulation during aortocoronary bypass surgery. The authors point to the extracorporeal circulation as a rare etiologic factor in development of hypopituitarism, as well as unusual clinical picture with dominant psychic disorders and diagnostic and treatment procedures.

Extracorporeal Circulation↗

PubMed1993

[The role of ultrasonography in the diagnosis of enlarged parathyroid glands].

The ultrasonographic diagnosis of parathyroid glands was introduced by the Japanese in 1975. Only after more perfect machines have been introduced, first of all by advancement of "real-time" technique, this method started being used as a routine. The paper shows results of ultrasonographic investigation in 200 patients separated into two groups. In the first group 100 patients were examined with a clinical suspect of primary hyperparathyroidism from which in 30 the existence of parathyroid gland adenoma was diagnosed. Scintigraphy of parathyroid glands was performed in the smaller group of patients; the comparison of these two methods was done, and in 77.7% cases coincidence was found. In the group of 10 operated patients comparison of the two mentioned methods was carried out, with surgical or pathohistologic findings and the coincidence was complete. In the second group 100 patients were examined belonging to the chronical program of hemodialysis, from which in 24 cases existence of swollen parathyroid glands was found. Comparison of ultrasonographic and scintigraphic findings was also done and the coincidence was 68.75%. At the end, the importance of ultrasonography in the first diagnostic stage of swollen parathyroid glands was pointed out.

Adenoma↗

PubMed1993

Renal osteodystrophy--pathophysiological aspects.

The aim of this study was to evaluate status of bone metabolism in patients on chronic maintenance dialysis, to elucidate dominant mechanisms in the genesis of renal osteodistrophy (ROD) with simultaneous measuring of biochemical regulators and parameters of bone metabolism and scintigraphic study of metabolic activity of the skeleton. We found that disturbance of skeletal homeostasis existed in all patients, dominant hyperparathyroid bone disease was found in most of them, mixed uremic osteodistrophy (hyperparathyroidism and vitamin D deficiency) was observed in less percent, i.e. only in 6% renal bone disease with low turnover due to osteomalacia or adynamic bone disease was present. Simultaneous determinations of most relevant factors of bone metabolism and scintiscan discover changes in skeletal homeostasis, and can prevent severe disturbances and treat adequately those ones which already exist.

Bone and Bones↗

PubMed1993

Hip scintigraphy in the diagnosis and evaluation of morbus Perthes.

During this research the role and significance of hip scintigraphy in diagnosis and evaluation of Perthes disease were examined. Three phase scan was applied in 35 patients clinically suspected of Perthes' disease. There were no false positive findings in 20 patients who did not suffer from Perthes' disease and all 15 who suffered from disease were scintigraphically positive. Our investigation confirmed clearly that late scintigraphy conducted with pinhole colimator can be used as a reliable method for diagnosis and evaluation of Perthes' disease.

Child↗

PubMed1993

Usage of quantitative static scintigraphy of the thyroid gland in defining the therapeutical dose of radioiodine.

In a group of 21 patients sent by endocrinologist for antihyperthyreosis therapy with radioactive iodine, we calculated and compared the weight of the thyroid gland by quantitative static scintigraphy, using two computed parameters--according to surface and volume of the gland. Statistically we came to the conclusion that weight of the thyroid gland calculated on the basis of surface gives significantly higher values than calculation by the use of volume. The calculation of weight of the thyroid gland using the surface of scan image is recommended, while quantitative static scintigraphy increases the standardisation of the procedure very much.

Adult↗

PubMed1992

[The metabolic X syndrome--4 case reports].

The study reviews current knowledge about metabolic X syndrome characterized by android obesity, arterial hypertension, insulin resistance with hyperinsulinemia and disturbed carbohydrate tolerance, a decrease of HDL cholesterol and an increase of the triglyceride rich VLDL particle level. The study describes 4 female patients having been diagnosed for this syndrome. Only an ontime and vigorous reduction of overweight, along with intensified physical activity can prevent later development of serious complications, first of all, in cardiovascular system.

Adult↗

PubMed1991

[Quantitative static scintigraphy of the thyroid gland].

The paper describes a static scintigram computer processed by the Siemens-Euromeni method which gives rather accurate parameters concerning the overall functional thyroid tissue mass, as well as functions of a certain thyroid gland node. It facilitates the calculation of the dimensions of the right-angled field which borders the thyroid gland (cm), radioactivity uptake (% of a given dose) in the whole gland, left and right lobe, the ratio between the left and right lobe uptake, the surface (cm2) of the whole gland and of the left and right lobe, the ratio between the left and right lobe surfaces, the number of impulses (imp) registered in the whole gland and in the left and right lobe, the volume (cm3) of the whole gland and of the left and right lobe, the ratio between the left and right lobe volume, as well as the surface and radioactivity uptake (% of a given dose and % of the total uptake) in the marked nodes. An additional calculation could offer an uptake ratio per surface unit between the node and paranodal tissue which, by the use of suppression tests offers a very accurate assessment of the function and compensation of each node. The method represents a significant contribution to an accurate assessment of the functional mass as well as to the assessment of nodal changes of the thyroid gland.

Humans↗

PubMed1991

[The importance of intact parathyroid hormone determination in the evaluation of parathyroid gland function].

The study investigates the importance of determining the intact parathormone in the evaluation of parathyroid gland function in different conditions of change in their function and the alteration of parathormone metabolism: primary and secondary hyperparathyroidism, hypoparathyroidism and hyperthyroidism. The role and place of intact parathormone determination in routine diagnostic schemes of calcium homeostasis disorders was reviewed by the simultaneous determination of the indicators of calcium and bone metabolism and other calcium homeostasis hormone regulators, as well as the C- and N-terminal parathormone fragments and by establishing their mutual links with the values of the intact parathormone.

Humans↗

PubMed1989

[Significance of highly sensitive (immunoradiometry assay) TSH in the evaluation of hypothalamo-hypophyseal-thyroid axis function].

A diagnostic value of immunoradiometric TSH assay in the evaluation of the function of hypothalamo-hypophyseal-thyroid axis was investigated in this paper. Normal values of basal TSH and TSH response during TRH test were determined by the use of ROC analysis. It was found out that there was a highly significant correlation between basal TSH and the responses during TRH test and that the diagnostic value of basal TSH in the evaluation of function of thyroid axis was almost identical to the diagnostic value of responses during TRH test. This finding pointed to the fact that basal TSH determination could replace the application of TRH test in diagnostic of thyroid axis disturbances. Comparing diagnostic value of basal TSH with other tests which served for the confirmation of thyroid axis disturbances, this test proved to be dominant, the most specific and the most sensitive in respect to other applied tests and could be regarded as the first step in diagnostic scheme of thyroid disturbances.

Humans↗

PubMed1989

[Radioimmunologic determination of growth factors. I. Determination of somatomedin C].

The authors' first experience in the determination of plasma somatomedin C concentration by the radioimmunologic method without extraction was put forward. The method itself was checked up through the routine indicators and the range of normal limits was established by the determination of this concentration in the plasma of 15 healthy persons. Values of plasma and serum determination greatly differentiated. By the determination of somatomedin C concentration and growth hormone during the insulin test in 8 persons it was shown that somatomedin C concentration did not change by the abrupt and short changes in growth hormone concentration. A good correlation was made by the comparison of sometomedin C and growth hormone basal concentration in 16 samples whereby the regulatory role of growth hormone in somatomedin C excretion was confirmed. In conclusion, radioimmunologic determination of sometomedin C in diagnostics and the therapy of growth disturbance was emphasized.

Female↗

PubMed1989

[Determination of 17-alpha-hydroxyprogesterone in the diagnosis of congenital adrenal hyperplasia].

On the basis of data from literature and by the use of commercial accessories radioimmunologic method of the determination od 17-alpha-hydroxiprogesteron (17-OHPG) serum level was determined in two variants: a) addition to the previous extraction, b) without extraction. It was initiated in the clinical work for diagnostic of congenital adrenal hyperplasia (CAH) induced by the enzymatic block of C21-hydroxilasis. 17-OHPG level was determined in a group of 15 children aged 2-12 of both sexes not suffering from endocrinous diseases. Mean values od X = 3.2 +/- 2.7 nmol/L and X = 4.3 +/- 3.3 nmol/L were obtained under a) and b), respectively. Also, 17-OHPG concentration was determined in 15 women without any endocrinous diseases by the method under b) and mean value of X = 2.5 +/- 1.7 nmol/L was obtained. 17-OHPG level was determined in a group of 7 children in whom CAH had been verified 3 days after the interruption of the substitutional therapy. According to the results of the investigation it was pointed out that there was a marked increase in 17-OHPG serum level (particularly by the use of b) method) which was far outside the range of reference values. In cases both with 17-OHPG determination and the daily pregnantriol excretion it was noticed that the increase in 17-OHPG was almost always accompanied by the increase in pregnantriol as well. Cortisolemia ranged from normal up to very lowered values.(ABSTRACT TRUNCATED AT 250 WORDS)

17-alpha-Hydroxyprogesterone↗

PubMed1988