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Biomedical subjects

L B Talner

Publications and source records attributed to L B Talner.

At least 73 records · Page 4Linked to original sources
PubMed1975

Inhibition of active sodium transport by radiographic contrast media.

We demonstrate that salts of diatrizoate and iothalamate, radiographic contrast agents, depress the active transport of sodium in the urinary bladder of the Columbian toad, Bufo marinus. Isolated toad bladders were incubated in isotonic Ringer's solutions with isosmolar displacement of sodium chloride by contrast media in experimental solutions. Sodium transport as measured both by short-circuit current (SCC) and by isotopic sodium flux was significantly depressed in the presence of sodium diatrizoate. Sodium transport measured by SCC was significantly depressed with sodium iothalamate and meglumine iothalamate. Equimolar methylsulfate Ringer's solution did not depress SCC. Although contrast media in isotonic Ringer's solutions depressed basal SCC, the vasopressin-stimulated increment in SCC was not depressed by contrast media. Separate experiments with hyperosmolar solutions (786 mM, as utilized in angiography) demonstrated equivalent suppression of SCC by contrast media and by other solutions made hyperosmolar with glucose or sodium methylsulfate, implying a general or nonspecific effect of hyperosomolarity. Inhibition of SCC by contrast media was reversible when the agents were removed by serial changes with standard Ringer's solution. Inhibition of sodium transport by contrast media might provide a basis for studies on some of the clinical toxicities of these agents.

Animals↗
PubMed1975

Renal artery dissection: a complication of catheter arteriography.

Renal artery dissection is a rare complication of catheter arteriography. Predisposing factors include atherosclerosis and fibromuscular dysplasia. Optimum management requires aortographic documentation of the extent of vascular obstruction. Dissections causing incomplete obstruction of blood flow can be treated with systemic anticoagulation to prevent downstream thrombosis and should be followed with serial isotope blood flow studies and LDH measurements. Dissection causing complete vascular obstruction usually requires immediate surgery, although spontaneous reestablishment of flow may occur. The 3 patients discussed illustrate a spectrum of findings, including the acute development of renovascular hypertension.

Adult↗
PubMed1974

Inferior vena caval extension of renal carcinoma: a lost cause? Roentgenographic and pathologic findings in surgical patients.

Using angiography it is possible to accurately define venous extension of renal carcinomas preoperatively. Modern surgical techniques permit successful removal of the tumors and vena cava en bloc. The left renal vein can be ligated, although a syndrome of temporary renal dysfunction may occur. The long term prognosis of such patients appears to correlate best with the pathologic stage of the resected specimen and cannot be predicted by preoperative studies unless these show evidence of metastases.

Aged↗
PubMed1972

Megacalyces.

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Adolescent↗