Biomedical subjects

L B Postnikova

Publications and source records attributed to L B Postnikova.

3 recordsLinked to original sources

PubMed2004

[Metabolism of proinflammatory cytokine (interleukin-1 beta) and oxidant activity of neutrophils in various forms of chronic bronchitis].

AIM: To study content of interleukin-1 beta (IL-1 beta) and free radical oxidation in neutrophils of blood, saliva and bronchoalveolar lavage (BAL) in chronic bronchitis for prediction of obstructive defects. MATERIAL AND METHODS: Enzyme immunoassay was used to measure IL-1 beta in the blood, saliva, BAL of 49 males with chronic bronchitis aged 39-72 years. Functional ability of the neutrophils to generate free oxygen radicals was assessed by luminol-dependent chemiluminescence. RESULTS: Patients with chronic obstructive bronchitis exhibited excessive accumulation of IL-1 beta in the blood and BAL, enhanced activity of hematosalivary barrier for IL-1 beta and production of active oxygen radicals by systemic and tissue neutrophils. CONCLUSION: Elevated concentration of systemic and tissue IL-1 beta, activation of free radical oxidation by blood neutrophils and BAL, enhancement of hematosalivary barrier for IL-1 beta can be considered as prognostically unfavourable factors of bronchial obstruction in patients with chronic bronchitis.

Adult↗

PubMed2004

[Significance of biochemical parameters of saliva in the diagnosis of chronic obstructive pulmonary disease at exacerbation].

The levels of calcium, magnesium and iron were examined on an automated biochemical analyzer in saliva and blood serum of 102 patients with chronic obstructive disease of lungs (CODL) and of 20 healthy subjects. Reliably reduced levels of magnesium and iron in saliva as well as low permeability of the hematosalivary barrier (HSB) for magnesium and its high permeability for iron were detected in group 2 and 3 of patients. The dynamic level of iron in saliva reached the normal value, whereas, a stable salivary deficiency was typical of magnesium. The above tests of levels of magnesium and iron in saliva and the determination of the distribution factor for the above cations can be used in evaluating a severity of bronchial obstruction and therapy efficiency in patients with CODL.

Adult↗

PubMed1996

[Mucociliary function in acute pneumonia].

Radioaerosol method was employed to follow up mucociliary transport (MT) efficacy in 97 patients with acute pneumonia (AP). The most pronounced suppression of MT was found in repeated and lingering AP. If causative agents were represented by adenoviruses, streptococci and influenza bacillus suppression of MT appeared more noticeable. Correlations of MT with pulmonary ventilation support the role of mucociliary insufficiency in genesis of bronchial obstruction in AP. The majority of the convalescents fail to achieve complete recovery of MT.

Acute Disease↗