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Biomedical subjects

L B Larsen

Publications and source records attributed to L B Larsen.

28 records · Page 2Linked to original sources
PubMed1995

The age-dependent incidence of injuries due to road traffic accidents in Odense, Denmark from 1980 to 1992.

The study was based on data concerning persons treated at Odense University Hospital as a result of road traffic accidents in the period 1980-92. Incidence rates of road traffic accident injuries were calculated on the basis of the population in Odense municipality. The study group included persons older or even 65 years of age, while persons younger than 65 years of age were used as a reference group.

Accidents, Traffic↗
PubMed1994

[Bicycle accidents 1980-1992. Do the official traffic accident statistics show the true picture?].

In Denmark, official statistics concerning road traffic accidents are based upon police recordings. In this study, these official data are compared to data from the emergency room at Odense University Hospital from the period 1980 to 1992. The purpose is to examine whether the official statistics show a reliable picture of the development in accident numbers compared to data from the emergency room. The results confirm that it is necessary to use data from the emergency room to describe the true development in numbers of bicycle accidents.

Accidents, Traffic↗
PubMed1994

[Aquatic injuries].

The pattern of injury sustained in an aquascape is described. The most serious and the highest number of injuries were sustained in the water chute (head, face). 15 percent of the injuries were bone or dental fractures. Prophylactic advice is given.

Adolescent↗
PubMed1993

Procathepsin D cannot autoactivate to cathepsin D at acid pH.

The amino acid sequence of the propart of bovine procathepsin D was determined at the protein level. Incubation of the isolated procathepsin D at pH 3.5-5.0 for 30-120 min leads to a 2 kDa reduction in its molecular mass, as seen by SDS-PAGE. The activation product is pseudocathepsin D and is the result of a proteolytic cleavage between LeuP26 and IleP27 in the propart. Incubation at pH 5.0 for 20 h of either procathepsin D or pseudocathepsin D results in both cases in approximately equal amounts of pseudocathepsin D and a further processed intermediate, nine amino acids shorter than pseudocathepsin D. No reaction products corresponding to cathepsin D with a mature amino terminus were observed, showing that autoproteolysis alone cannot generate the mature form found in the lysosomes.

Amino Acid Sequence↗
PubMed1989

Effects of 3-deazaadenosine, an inducer of HL-60 cell differentiation, on human blood cells in vitro.

The adenosine analogue 3-deazaadenosine (c3 Ado) induces differentiation of human promyelocytic leukemia HL-60 cells in vitro. c3 Ado affects in vitro viability and growth of cells involved indirectly (cytokine-producing cells) and directly (transformed myeloid cells) in leukemic cell differentiation. Growth inhibition of proliferating cells is achieved at c3 Ado concentrations between 10-100 microM. Concentrations higher than 100 microM affect viability of proliferating and nonproliferating cells.

Cell Differentiation↗