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Biomedical subjects

L Aubert

Publications and source records attributed to L Aubert.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

[Malignant fibrous histiocytoma of soft tissue: atypical presentations. Value of combined surgery and chemotherapy].

The authors report five cases of malignant fibrous histiocytoma of the soft tissues, some of them with atypical presentation (necrotizing tumor, hypereosinophilic syndrome, dermatomyositis). This is the first case of polymyositis associated with malignant fibrous histiocytoma. The tumor occurs between the fifth and the seventh decade, principally as a mass on the proximal lower limb. Local recurrence and metastasis occurs in 50% of patients. Prognosis is dependent on both the surgical possibilities and the characteristics of the tumor (site, size, histologic grade). Surgery alone is inadequate. Adjuvant chemotherapy improves the 5-year survival.

Adult↗
PubMedDate not supplied

[Dense bone metastases and hypophosphatemic osteomalacia during the course of prostatic cancer (author's transl)].

In patient bearing an advenced prostatic carcinoma with bony metastases, a major hypophosphoremia had led to the detection of an osteomalacia. As far as we know, three observations of the same syndrome have been published previously. As a pathogenic hypothesis, we propose that this tumor secret a substance which inhibit the action of vitamine D. Hypophosphoremia could result from an hyperparathyroid due to hypocalcemia.

Aged↗
PubMedDate not supplied

[Callosogenital dysplasia].

A nosological entity, calloso-genital dysplasia, is described from a case of primary amenorrhoea with coloboma and total agenesis of the corpus callosum. Deficiency of the thalamic gonadotropic hormone secretion was elicited, together with normal or moderately elevated prolactinaemia, the significance of which is discussed. Thyrotropic, somatotropic and corticotropic functions were normal. It may be that the hypogonadotropic eunuchoidism of this 24-year old woman with normal olfaction evolved towards panhypopituitarism over a number of years, but in such a malformation that had not changed since birth the thalamic hypophysiotropic dysfunction seems to be fixed and stable. Unless a most unlikely coincidence occurred, the primary amenorrhoea seems to be related to the malformation. Agenesis of the corpus callosum with panhypopituitarism is well known, but this case is original in that the pituitary deficiency is very limited. A comparison with its mirror image, olfacto-genital dysplasia or Kallman's syndrome is tempting, but it remains to be documented anatomically by other cases.

Abnormalities, Multiple↗