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Biomedical subjects

L Aubert

Publications and source records attributed to L Aubert.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Persistent fever of dental origin].

Based on 5 cases of unexplained prolonged fever, the authors stress the need to systematically look for a dental focus of infection. They discuss the difficulties in determining the site of the probable causal focus and stress the uncertain pathogenic relationship between the dental focus of infection and the fever. The extraction of infected teeth leads to a cure, however, the functional disadvantages of multiple extractions need to be carefully taken into account.

Adult↗
PubMed1989

[Waldenström's macroglobulinemia with cerebral lymphoproliferative involvement of tumor appearance (Bing and Neel syndrome). An anatomo-clinical case].

The authors report the case of a 58 year old woman with a 5 year history of Waldenström's disease, who presented with perivascular confluent and multifocal lymphoproliferative cerebral involvement (Bing and Neel syndrome). The lymphoproliferative process was limited to the brain matter and respected the meninges, posing the problem as to its origin. It resulted in a tumoral syndrome with intracranial hypertension leading to coma and death after 6 months. This case is reviewed in the light of two similar cases in the medical literature.

Brain Diseases↗
PubMed1984

[Diffuse diverticulosis of the small intestine and malabsorption syndrome. Apropos of a case].

A case of acquired jejuno-ileal malabsorption complicated by vitamin B12 malabsorption with macrocytic anemia and posterior column dysfunction is reported. Few such observations have been published in the medical literature. In the light of published studies and case-reports the authors review the pathogenic hypotheses concerning the formation of diverticula, the part played by bacterial infection in the mechanisms of malabsorption and the value of antibiotic therapy in the initial treatment of this condition.

Aged↗
PubMed1983

[Polycythemia vera and 2,3-diphosphoglycerate deficiency. Apropos of 2 cases].

Two cases of mistaken diagnosis of polycythemia vera leading to useless or dangerous treatments exemplify the old saying "primum non nocere". Absolute polycythemia which lacks both the specific characteristics of polycythemia vera and lacks both the specific characteristics of polycythemia vera and any tumoral etiology (particularly renal) but is accompanied with normal arterial oxygen saturation should suggest the possibility of an anomalous hemoglobin with increased affinity for oxygen. Two alternative mechanisms may be present: anomalous hemoglobins due to the substitution of an amino acid or, as in the two reported cases, a deficit in intraerythrocytic 2,3 diphosphoglyceride. In both cases, polycyhthemia is compensative and does not warrant therapy.

2,3-Diphosphoglycerate↗
PubMed1983

[Horton's disease. Paucisymptomatic forms. Apropos of a series of 37 cases].

Giant cell arteritis (Horton disease) is of growing significance among conditions met in elderly patients. Typical forms are no longer overlooked but occult or incomplete forms, in which one or more characteristic features are lacking, are misleading and may result in a dramatically effective therapeutic decision being deferred. These paucisymptomatic or misleading forms of giant cell arteritis are discussed with reference to 37 personal cases and a review of the medical literature. They have been categorized into ocular, febrile or anemic monosymptomatic forms, extraocular ischemic forms and pseudotumoral forms. Correct diagnosis is worthwhile, in order to avoid the serious consequences of overlooked disease and unnecessary traumatic investigations.

Anemia↗
PubMed1982

Polyarteritis nodosa with bilateral ureteric involvement.

Renal insufficiency in necrotizing vasculitis is usually the result of parenchymal damage. A case of polyarteritis nodosa presenting obstructive nephropathy with bilateral ureteric stenosis is reported. The role of the concurrent crescentic glomerulonephritis in the mechanism of renal failure is discussed.

Acute Kidney Injury↗
PubMed1982

[Clinical aspects, outcome and prognosis of Horton's disease. Retrospective study of 47 cases].

The authors report their experience of Horton's disease in 47 histologically confirmed cases treated between 1966 and 1979. The symptomatology is recalled with the incidence of the various clinical and biochemical signs. The actuarial survival curve shows a 71.2 p. cent three year and a 61 p. cent five year survival rate. There was no statistically significant difference at three years with a control population. The duration of maintenance therapy was, on average, of 24.8 months, never less than 15 months and sometimes reaching 60 months. The average maintenance dose was 12 mg. Specific and non-specific complications are discussed. The incidence of refractory and cortico-dependent forms shows that the optimal treatment for this disease has yet to be found; the often brilliant initial results of corticotherapy do not reflect its long-term efficacy.

Adult↗
PubMed1981

[45X/46XY/46XrY mosaic with banding and the Turner phenotype (author's transl)].

A chromosome make-up of 45X/46XY can be associated with gonadal dysgenesis, partial dwarfism and Turner-like congenital abnormalities according to Simpson's terminology, as can pure 45X. The Turner syndrome in the form of X/XY is rare. There is a double interest in the case that we report apart from its rarity; first because it has been possible to show lack fluorescence of the Y chromosome which can occur in the pathogenesis of clinical manifestations, when a third clone exists as an addition together with a ring chromosome Y. Because the risks of tumours developing are great when the caryotype includes a Y even if it is one with banding the adnexae should be removed routinely in these cases. A tumour can develop in these girls whereas there is practically no risk if the caryotype is 45X or a mosaic without a Y in it.

Child↗
PubMed1980

Progressive ophthalmoplegia associated with asymptomatic primary biliary cirrhosis. Histologic, histochemical, cytochemical, and ultrastructural studies of muscle and liver biopsy specimens.

The authors report a case of progressive ophthalmoplegia associated with asymptomatic primary biliary cirrhosis diagnosed by the finding of antimitochondrial antibodies and liver biopsy. Electron microscopic findings showed mitochondrial abnormalities, especially intramitochondrial paracrystalline inclusions, not only in skeletal muscle but also in hepatocytes. Enzymatic digestion revealed the acidic protein nature of the intramitochondrial paracrystalline inclusions of the hepatocyte. To the authors' best knowledge, the association of progressive ophthalmoplegia and primary biliary cirrhosis has not yet been reported in the literature. Despite the mitochondrial abnormalities in both skeletal muscle and liver and the presence of serum antimitochondrial antibodies, no apparent connection between these two diseases was found.

Adult↗