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Biomedical subjects

L Asch

Publications and source records attributed to L Asch.

At least 19 recordsLinked to original sources
PubMed1992

[Sciatic radiculalgia with muscular hypertrophy].

A 52-year-old male developed hypertrophy of the right calf after several bouts of right lumbar pain with sciatica. Electromyography disclosed evidence of demyelination in the territories of the right S1 and S2 roots. Microscopic studies showed both atrophic muscle fibers scattered among fibers of normal caliber and a large number of hypertrophic fibers. Post-sciatica hypertrophy of the calf is a true muscle hypertrophy with muscle weakness. Electromyography may show unusual tracings with repeated complex bursts or continuous activity of motor units. Muscle enzyme levels may be elevated. The size of hypertrophied fibers varies across cases. The cause of the muscle fiber hypertrophy may be either stretching due to the action of antagonists or unusual electrical activity.

Electromyography↗
PubMed1989

[Ossification after transplantation of model cartilage in the rat patella].

The cartilage model of the rat's patella constitutes a formation susceptible of inducing ossification, following its transplantation in a variety of sites (muscle, thyroïd, testis, ovary, anterior chamber of the eye, etc.), including those considered inappropriate in other experiments of induced ossification (liver, kidney). So we have an experimental model allowing the influence on the osteogenesis of various factors, local or general, natural or experimental, to be studied. Ossification occurs in this model only in cases of histocompatibility between donor and recipient. It is constant after autotransplantation or isotransplantation. It is never seen after heterotransplantation. In cases of homotransplantation its frequency varies: this is not influenced by the technical conditions of implantation but by tissue compatibility and the age of the animals giving and receiving. A private perichondrium cartilage retains its osteogenic potency. A cartilage killed by alcohol or cold no longer demonstrates its osteoformative capacities, even when put into contact with a living cartilage. Our findings are difficult to reconcile with the hypotheses invoking the osteogenic potency of the periosteum, or the intervention of substances either inducing osteoformation or inhibiting vascular invasion, for the explanation of endochondral ossification. However, they lead one to the opinion that chondrocytes play an active role in its release.

Aging↗
PubMed1988

[Experimental studies on the factors of osteogenesis by transplantation of patellar cartilage framework in rats].

The cartilage framework of the patella in rats is capable of inducing ossification after homotransplantation in many various sites: muscle, thyroid, testicle, ovary, kidney, anterior chamber of the eye, etc. The frequency of ossification does not depend on the technical conditions of the transplant, but on the age of the donors and receivers; it approximates 84 p. cent when the two rats are three weeks old. It is close to 100 p. cent in case of autotransplant. It is non-existent in case of heterotransplantation. A cartilage that is killed by alcohol or cold, has no longer osteogenetic abilities, even if it is placed in contact with live cartilage. The transplant of patellar cartilaginous framework represents a model which may be used to study the factors responsible for physiological ossification as well as the effect of various experimental conditions on osteogenesis.

Animals↗