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Biomedical subjects

L Arisz

Publications and source records attributed to L Arisz.

At least 145 records · Page 8Linked to original sources
PubMed1978

Loss of amino acids during hemodialysis: quantitative and qualitative investigations.

In three patients the total amino acid losses (free plus peptide-bound) in dialyzate have been assayed by means of gas-liquid chromatography. During a period 3--4 months the average losses varied from 115--178 mg per kg of body weight per dialysis treatment. The weekly mean essential amino acid losses amounted to 3--4% of the dietary intake. The concentrations in the dialyzate of non-essential amino acid fell considerably during the dialysis procedure, whereas the concentrations of most of the essential amino acids remained at a fairly constant level. It is concluded that considerable quantitative but no qualitative differences exist between the patients with respect to amino acid losses.

Amino Acids↗
PubMed1977

The clinical course of IgA nephropathy in adults.

Renal function was studied in 25 patients with IgA nephropathy, aged 15--48 years, during a mean follow-up period of 47 months. GFR remained normal in ten patients but decreased in 15, necessitating regular hemodialysis in five. The evolution of GFR was not related to the degree of increase of the serum IgA level or to the presence of recurrent respiratory tract infections. The mean age of the patients with decreased GFR was ten years older and the mean follow-up time 20 months longer than of patients with maintained renal function. Also these patients had more proteinuria and were more frequently hypertensive. Their initial renal biopsies showed histologic evidence of nephron loss. The hypothesis is discussed that IgA nephropathy in adults not infrequently follows a slowly progressive course.

Adolescent↗
PubMed1977

Impaired lymphocyte function and neutrophil damage during the first hours of hemodialysis.

Tests of T lymphocyte function, as lymphocyte stimulation by phytohemagglutinin (PHA) and concanavalin A (Con A), decreased during the first 2 hours of dialysis to approximately 20% of the predialysis value but returned to near normal within 4 hr. No change in the percentage of T cells was noted. Lymphocyte function in blood obtained from the arterial side fo the dialyzer 1 hour after the start of dialysis was better than that in blood from the venous side, though lower than before dialysis. Neutrophils in blood from the venous side of the dialyzer showed decreased density and decreased carbonyl iron phagocytosis. These changes were not found in blood from the arterial side of the dialyzer, suggesting that damaged neutrophils were retained in the patient. Neutrophil damage persisted during the first 4 hours of hemodialysis.

Antigens↗
PubMed1976

The effect of indomethacin on proteinuria and kidney function in the nephrotic syndrome.

In 19 nephrotic patients on a dietary intake of 20 mEq sodium/24 hours, indomethacin caused an immediate decrease in glomerular filtration rate (GFR) and urinary protein excretion, an effect completely reversible upon withdrawal of the drug. As a consequence of lower protein excretion, there was eventually a rise in GFR. It is proposed that the therapeutic effect of indomethacin in nephrotic syndrome is caused by its inhibiting action on renal prostaglandin synthesis, thereby potentiating the effect of the renin-angiotensin system on the kidney. The difference between the decrease in GFR (mean 35%) and proteinuria (mean 55%) and the more selective proteinuria during indomethacin administration may be explained by quantitative and qualitative differences in protein leakage between outer cortical and inner cortical nephron populations.

Adolescent↗
PubMed1976

The effect of indomethacin on kidney function and plasma renin activity in man.

125Iothalamate and 131I-hippuran clearances, sodium excretion and plasma renin activity (PRA) before and during indomethacin administration in an oral dose of 3 x 50 mg/day were studied in volunteers with a normal or reduced kidney function, as well on non-sodium-restricted as on sodium-restricted diet. Indomethacin induced a temporary sodium and water retention and a decrease in glomerular filtration rate. It also lowered PRA. The latter phenomenon did not depend on sodium retention and was present within 2 h after an oral dose of 50 mg. The results may be explained by indomethacin-induced inhibition of prostaglandin synthesis.

Glomerular Filtration Rate↗