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L Angervall

Publications and source records attributed to L Angervall.

At least 55 records · Page 3Linked to original sources
PubMed1983

Myxoid chondrosarcoma of the synovial tissue. A clinicopathologic, histochemical, and ultrastructural analysis.

The first case of a myxoid chondrosarcoma, originating in the synovia of the joint and tendon sheaths of the ankle in a 37-year-old man, is reported. Light microscopically the tumor was similar to extraskeletal myxoid chondrosarcoma as previously described. The chondromatous nature of the tumor was further indicated by the histochemical analysis, which revealed the presence of chondroitin 4- and 6-sulphate in the tumor matrix. Ultrastructurally, chondroblast-like cells with dilated rough endoplasmic reticulum, abundant glycogen, some lipid droplets and numerous microvilli-like projections of the cytoplasm dominated. Also mitochondria-rich cells were observed as well as intermediate cell forms. Based on the observations in this case, the frequent occurrence of synovial chondromatosis, the assumed synovial origin of extraskeletal chondromas and the wide morphologic and functional spectrum synovial intima cells may cover, it is suggested that the myxoid chondrosarcoma originated from the synovial intima cells.

Adult↗
PubMed1983

Clear-cell sarcoma of tendons and aponeuroses. An immunohistochemical and electron microscopic analysis indicating neural crest origin.

A clinico-pathological, light microscopic and immunohistochemical study of 15 clear-cell sarcomas, with an ultrastructural analysis of 6 of the tumors, is presented. The tumors showed a strong predilection for tendons and aponeuroses of the extremities in predominantly young and middle-aged people. The clinical setting, course and light microscopic appearance agree well with the original description by Enzinger (1965). Nine of the 15 patients developed metastases, most of them including lymph nodes, and 8 of the patients had died at the time of follow-up (median follow-up time 4.8 years). Reducing pigment was demonstrated within the cells of 2 tumors. Ultrastructurally the 6 tumors studied had a uniform appearance with characteristically rounded or oval tumor cells with a single nucleus containing one or two very prominent nucleoli, a light-staining cytoplasm with a moderate amount of organelles and a variable content of glycogen. Polymorphic melanosomes were seen in the cells of one of the tumors. External laminas enclosed groups of tumor cells and invested parts of individual tumor cells. With immunoperoxidase analysis for S-100 protein positive staining was observed in the vast majority of the tumor cells of all 15 clear-cell sarcomas. Metastases appearing in 9 of the 15 cases showed positive staining for S-100 protein. There was a strong staining of the cytoplasm and generally a weak and varying staining of nuclei. The immunohistochemical and electron microscopic findings indicate that clear-cell sarcoma is a homogenous entity among soft tissue sarcomas, of probable neural crest derivation.

Adolescent↗
PubMed1983

Enzyme histochemistry of malignant fibroblastic histiocytic tumors. A light and electron microscopic analysis.

The enzyme pattern of 13 cases of malignant fibrous histiocytoma (MFH) and 11 cases of myxofibrosarcoma (MFS), a malignant myxomatous soft tissue tumor of fibroblastic histiocytic origin, has been studied. 6 of the 13 MFHs were analyzed enzyme histochemically at the light microscopic level and 7 on the ultrastructural level; of the 11 MFSs 9 were analyzed enzyme histochemically at the light microscopic level and 2 on the ultrastructural level. Differences were observed in the subjectively estimated enzyme activity between low grade MFS and high grade MFS and MFH, and also between histiocyte-like and fibroblast-like tumor cells. Generally a strong reaction of oxidoreductase enzymes (NADH2-diaphorase, NADPH2-diaphorase, glucose-6-phosphate dehydrogenase) and hydrolytic enzymes (acid phosphatase and leucine aminopeptidase) was found in the high grade tumors and was usually higher in the histiocyte-like than in the fibroblast-like cells. Ultrastructurally acid phosphatase occurred predominantly in primary and secondary lysosomes and Golgi zones of the histiocyte-like cells. A strong reaction of alkaline phosphatase was found light microscopically in 2 of 5 MFHs and 5 of 9 MFSs. Ultrastructurally alkaline phosphatase was located along the cytoplasmic membrane of predominantly fibroblast-like cells in 3 of 7 MFHs and 1 of 2 MFSs. The results agree with the concept of two main cell types in MFH and MFS, fibroblasts and histiocytes.

Adult↗
PubMed1982

A multivariate analysis of the prognosis after surgical treatment of malignant soft-tissue tumors.

Ninety-seven patients who had received their primary and definitive surgical treatment for a soft-tissue sarcoma during the years 1956--1976 were studied with respect to local recurrence, metastasis, and survival. The aim of the treatment was to eradicate the tumor while preserving good function. The influence of host and tumor properties and different diagnostic and surgical procedures on the prognosis was studied by means of nonparametric multivariate analysis. Ninety-four percent of the tumors were located in the extremities. Malignant fibrous histiocytoma was the most common histologic type. A four-grade scale of histologic malignancy was used. Eighty-eight percent of the tumors were Grade III or IV. In 85% of the patients with an extremity lesion, local extirpation was carried out. The overall local recurrence rate was 21.7% and in 76 patients who underwent an adequate surgical procedure it was 6.6%. The overall five-year survival rate was 59%. The survival depended on the local control of the primary tumor, which was related to the adequacy of the surgical procedure and to the histologic grade of malignancy. No patient with a Grade I or II tumor died. The five-year survival rate for patients with Grade III tumors was 68% and for patients with Grade IV tumors 47%.

Adolescent↗
PubMed1982

Atypical lipoma.

In a previous clinico-pathologic and prognostic study of a Swedish national series of liposarcoma the designation atypical lipoma was suggested for a group of well-differentiated non-metastasizing liposarcomas characterized by only moderate nuclear atypia. In the present report, 21 new cases of atypical lipoma are described. The tumors were mainly composed of univacuolated fat cells without cellular or nuclear atypia, but also showed univacuolated fat cells with enlarged, moderately polymorphic, dark nuclei. In two of the tumors a few multivacuolated fat cells with scalloped nuclei were found. Small multinucleated cells with overlapping, peripherally arranged nuclei, reminiscent of so-called floret-like cells as in pleomorphic lipoma, could occasionally be seen. Areas of generally delicate linear or patchy fibrosis with atypical nuclei were a common finding. Two atypical lipomas were studied ultrastructurally. The ultrastructural findings suggest that the nuclear polymorphism is of a neoplastic nature rather than of a regressive changed. Nine atypical lipomas were located intramuscularly, two intermuscularly and ten subcutaneously. Five of the subcutaneous tumors and three of the inter-and intramuscular tumors recurred one or more times. Most of them, particularly the subcutaneous ones, had primarily been diagnosed as ordinary lipomas, but re-examination of the histological sections after one or more recurrence revealed overlooked nuclear atypia. Metastasis or dedifferentiation at recurrence was not seen in any case.

Adult↗
PubMed1982

Alveolar rhabdomyosarcoma: a cytogenetic and correlated cytological and histological study.

A correlative, histologic and cytologic study of seven cases of alveolar rhabdomyosarcoma and chromosome analysis using the G-banding technique (in case 1) is presented. The histologic pattern was characterized by pseudo-alveolar structures, separated by fibrous septa. Primitive, dark, round cells predominated, but differentiated rhabdomyoblasts were found in all cases, and so were multi-nucleated giant cells. Unequivocal cross striation was seen in two cases. Cytologically, the tumors were highly cellular and small, undifferentiated tumor cells predominated. Large polymorphous, sometimes multi-nucleated, cells often with an elongated cytoplasm and eccentric nucleus were observed in all cases. The cell-types found could be well correlated to those identified in the histologic sections. The cytogenetic study revealed a karyotype profile, showing three 2q markers and only one chromosome type No. 13. The observations are different from the karyotype profile of embryonal rhabdomyosarcoma. However, further studies are necessary to elucidate this question.

Adolescent↗
PubMed1981

Malignant giant cell tumor of soft tissues: a clinicopathologic, cytologic, ultrastructural, angiographic, and microangiographic study.

A clinical, angiographic, pathologic-anatomic, and cytologic study of 12 cases of malignant giant cell tumor of soft tissues is presented. Preoperative angiography was performed in five cases, one of which was also studied by microangiography. Aspiration cytologic examination was performed in five cases and electron microscopy in one case. In nine cases the tumors were deeply situated and in three they were subcutaneous. In six cases the tumors were located within the lower extremity, in four cases in the upper extremity and shoulder, in one case retroperitoneally and in one case in the neck. Except for one case, the follow-up period was 1--14 years. Seven of the patients had died from metastasizing tumor disease at the time of follow-up. High vascularity and rapid circulation characterized the tumors at preoperative angiography. Conventional histology, aspiration cytology, and electron microscopy disclosed histiocyte-like cells, fibroblast-like cells, and multinucleated giant cells of both osteoclast-like benign and pleomorphic malignant type, in varying proportions. The histiocyte-like cells and the giant cells exhibited phagocytic activity at these examinations. The finding of phagocytosing pleomorphic malignant cells and giant cells of osteoclast type in aspiration cytologic material strongly favors the diagnosis of malignant giant cell tumor of soft tissues.

Adult↗
PubMed1981

Effects on rat fetuses of intrauterine injections of insulin.

The effects on rat fetuses of a single intrauterine injection of long-acting insulin with respect to length, body and organ weights, total lipids, phospholipids, cholesterol, neutral fat, total nitrogen and water content were investigated. At the age of 498 hours the fetuses were injected in utero with 2 IU of long-acting insulin or a control solution. Twenty-four hours after the injections the insulin-treated fetuses weighed about 10 per cent more than the control fetuses, 5.32 +/- 0.05 g (75 fetuses) and 4.85 +/- 0.05 (73 fetuses) respectively (p less than 0.001). The body lengths were 54.1 +/- 0.2 mm and 52.9 +/- 0.2 mm respectively (p less than 0.001). The insulin-treated fetuses had higher organ weights and higher content of total lipids, phospholipids and neutral fat. The amount of total lipids was higher in insulin-treated fetuses even after taking into account differences in body weight, suggesting that the insulin-treated fetuses were obese. The finding of significantly lower water content in insulin-treated fetuses at equal body weight is consistent with the higher fat content. There was no increase in total nitrogen or length in the fetuses in the insulin-treated group compared to control fetuses at equal body weight indicating that the administered insulin mobilized maternal proteins and that protein, as well as length, increased proportionately to overweight. For quantitative analysis of morphological and biochemical variables dependent upon body weight, as in this investigation, multivariate analysis is indispensable.

Animals↗
PubMed1981

Leiomyosarcoma of the soft tissue. A correlative cytological and histological study of 11 cases.

Leiomyosarcoma of the soft tissues is a well-defined and characteristic entity histologically but correlative cytomorphological studies are lacking. A correlative histological and cytological study of 11 cases is presented. The leiomyosarcomas were characterized histologically by elongated tumour cells arranged in bundles intersecting each other at wide angles. The nuclei were elongated and often blunt-ended, tending to be aligned in tandem-position or in rows. The smears from leiomyosarcoma were poor in tumour cells and most cells were arranged in clusters of strands. The characteristic blunt-ended cells and nuclei of leiomyosarcoma could be identified in the smears and the nuclei were focally arranged in rows and sometimes in parallel. Nuclear atypia permits diagnosis of malignancy, although the atypia was generally not very pronounced. We consider that a knowledge of the corresponding histological features is mandatory for differentiating cytologically between various soft tissue sarcomas, including leiomyosarcomas. Further correlative cytological and histological studies of other soft tissue sarcomas are necessary for a more valid interpretation of the smears from leiomyosarcomas.

Adult↗
PubMed1980

Primary leiomyosarcoma of bone: a study of five cases.

Five cases of leiomyosarcoma of bone are described. The patients, 3 men and 2 women, ranged in age from 24 to 74 years. Four of the five tumors were located in the distal half of the femur. Radiographically, all tumors presented as purely osteolytic lesions. Angiography, performed in 3 cases, revealed hypervascularity and the presence of irregular, tortuous vessels at the site of the lesion in 1, but not in 2 others. Histologically, the five tumors showed features characteristic of leiomyosarcomas. The most prominent features were blunt-ended, cigar-like, chromatin-rich nuclei in elongated acidophilic cells arranged in bundles which intersected each other at wide angles. The importance of trichrome stains, such as van Gieson stain, for th recognition of leiomyosarcomas is emphasized. Electron microscopic examination, performed in 3 cases, showed as the most prominent features spindle-shaped cells in parallel arrangement containing abundant myofilaments which elongated densities, pinocytotic vesicles, and basal lamina structures.

Adult↗
PubMed1979

Concomitant arteriovenous vascular malformation in skeletal muscle: a clinical, angiographic and histologic study.

A vascular malformation in skeletal muscle is described in 4 patients. Pathologically and anatomically, it consists of an abundance of concomitant arteries and veins and thick-walled capillaries. Angiography demonstrates the high vascularity of the lesion, and contrast medium appears early in draining veins indicating arteriovenous shunting. In the angiograms, the highly vascular region displays a certain striation which is due to the presence of muscle fiber bundles running between the pathologic vessels. This angiographic picture suggests benignity: an intramuscular malignant tumor rarely leaves intact muscle fiber bundles passing right through it.

Adult↗
PubMed1978

Recurrent and metastasizing gastric leiomyoblastoma (epithelioid leiomyosarcoma) associated with multiple pulmonary chondro-hamartomas: long survival of a patient treated with repeated operations.

A 15-year-old girl was operated for gastric leiomyoblastoma (epithelioid leiomysocarcoma) with metastasis to a regional lymph node. She has subsequently been operated on twice: once for local recurrence and metastases 9 years after her initial operation and once for an intraabdominal lymph node metastasis. Now, 13 years after her first operation for gastric leiomyoblastoma she is free from symptoms and signs of disease. Preoperative angiography was helpful in diagnosing the recurrence and planning the second operation. Our observations speak in favor of surgical treatment of recurrent and metastasizing gastric leiomyoblastoma. This patient was also operated for multiple pulmonary chondro-hamartomas, primarily suspected to be metastases. Coincidence of gastric leiomyoblastoma and pulmonary chondro-hamartoma does not seem to be due to chance alone.

Adolescent↗
PubMed1978

Congenital solitary fibromatosis of the skeleton: case report of a variant of congenital generalized fibromatosis.

A study of a 3-month-old boy with a solitary form of congenital generalized fibromatosis of the skeleton is presented. Radiographic examination revealed a shortening of the right ulna and an osteolytic lesion in the distal metaphysis extending to the epiphysis. The histological appearance seems to be consistent with previously described cases of generalized congenital fibromatosis of soft tissues and skeleton. Ultrastructurally, the tumor cells resembled primitive fibroblasts. The lesion was curetted 3 times and filled with bone transplants before it finally healed. At follow-up of the boy at age 13, there were no signs of the tumor.

Bone Neoplasms↗
PubMed1978

Liposarcoma of the neck: a clinicopathologic study of 4 cases.

A clinicopathological study of 4 patients with liposarcoma in the neck treated surgically is presented. Three of the liposarcomas were located in the supraclavicular region, two to the right one to the left, and one appeared to the left in the back of the neck. Liposarcoma rarely involves the head and neck region. A survey is given of the few reported liposarcomas in this region. Two of the tumors in the present series were well differentiated, one of which recurred repeatedly. The other two tumors were round-cell and pleomorphic in type, both of which recurred. At the end of follow-up 11 and 9 years, the two patients with well-differentiated liposarcomas were alive. The other two patients had died after 5 and 4 years from intercurrent disease and metastatic spread, respectively. The histopathological basis for the diagnosis, distinguishing features of intramuscular (infiltrating) lipoma, hibernoma and spindle cell lipoma, as well as the treatment, are discussed.

Adult↗
PubMed1978

Hemangiopericytoma: a clinicopathologic, angiographic and microangiographic study.

A clinicopathologic study of 11 hemangiopericytomas is reported, and the results of clinical angiography in 4 patients and a correlated microangiographic-histologic study of 1 tumor are presented. Six of the tumors were collected and accepted as hemangiopericytomas in a review of 42 tumors registered as hemangiopericytoma in the Swedish Cancer Registry during the period 1958--1968. The other 5 tumors occurred in patients treated by us. The histologic examination and the follow-up information showed that it can be difficult to predict the prognosis on morphologic grounds, that borderline tumors exist and that a recurrence as well as a metastasis may dedifferentiate. The tumors studied by clinical angiography all proved to be highly vascular. Irregular vessels of varying caliber were filled with contrast medium and, in addition, a prominent diffuse opacification took place. Early filling of veins was not noted despite the high vascularity. The correlated microangiographic-histologic study suggests that the irregular vessels seen on clinical angiograms corresponded to wide, angulated, thin-walled vessels without muscle coat or elastic tissue, while the diffuse opacification was caused by a dense network of delicate, branching, slit-like capillary spaces.

Adult↗