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Biomedical subjects

L Andolsek

Publications and source records attributed to L Andolsek.

36 records · Page 2Linked to original sources
PubMed1969

Preliminary evaluation of four oral contraceptives containing only progestogens.

One hundred and seventy-five women took part in a comparative clinical trial of four progestogen-only oral contraceptives and were followed for either a year or until treatment was discontinued. Megestrol acetate 0.25 mg. was found to be a very ineffective contraceptive, 21 out of 43 women becoming pregnant. One, three, and four pregnancies occurred during treatment with norethisterone acetate 0.3 mg., norgestrel 0.05 mg., and chlormadinone 0.5 mg., respectively, corresponding to pregnancy rates of 4, 9, and 12 per 100 woman-years of use.All three effective progestogens were very much less acceptable than modern low-dose combined oral contraceptives. Discontinuation of treatment for medical reasons (particularly menstrual disturbances) during the course of only one year affected 24% receiving norethisterone acetate, 38% receiving norgestrel, and 46% receiving chlormadinone.

Adolescent↗
PubMedDate not supplied

First trimester abortion by vacuum aspiration: interphysician variability.

This study compares the performances of four physicians using two types of plastic cannulae (flexible and rigid) for 1100 vacuum aspiration procedures. The criteria for assessing physician performance by cannula type were: (a) frequency of cannula obstructions, (b) amount of retained tissue obtained by sharp curettage after vacuum aspiration, (c) estimated blood loss during the procedure and (d) time required to perform the procedure. Data for each physician were compared and yielded significantly different results. The length of time required to use the cannula differed significantly among physicians; two of them had significantly shorter cannula times with the flexible instrument. The others had the lowest distributions of blood loss and the most difference between cannula usage. Consistent grouping over several variables suggests that differences in these criteria are more likely to be attributable to subtle distinctions in operator technique than to variations in equipment.

Abortion, Induced↗
PubMedDate not supplied

[Influence of the kind of anesthesia and length of hospitalization on the frequency of early complications of abortion].

A case-control study of the safety of early vacuum aspiration, when performed as an outpatient/inpatient procedure in local/general anaesthesia was undertaken in Ljubljana. Three thousand and four healthy women were observed. General anaesthesia was applied to 1509 women and local to 1495 women. The inpatient procedure required at least overnight stay, the outpatient one only five hours. No differences in complication rates of any clinical importance between the different types of services and anaesthesia were observed. The overnight stay resulted in no decrease in complications but in an even greater bed occupancy beyond that expected.

Abortion, Induced↗
PubMedDate not supplied

[Perspectives of intrauterine contraception].

The author describes the current research in intrauterine contraception. It is directed in two ways: to improve the design of inert devices and to construct an optimal bioactive IUD. The design of the inert IUD should be adapted as much as possible to anatomical and functional conditions of the uterus. In developing new bioactive devices it is ained at finding the optimal dosage of metals and hormones as well as the new material acting as carriers of bioactive substances. With new constructions and the determination of the optimale dosage of antifertile and antifibrinolitic substances it is hoped to reduce three main insufficiences of intrauterine contraception: bleeding, expulsion and pregnancy.

Female↗
PubMedDate not supplied

[Sterilization--where are we and what do we want?].

According to the estimation from the mid-eighties, about 135 million people were sterilized, 95 million females and 40 million males. In 1977, sterilization was legalized in Slovenia, in 1978 in Croatia. In the period from 1978 to 1989, 4,503 females and 654 males were sterilized in Slovenia. The majority of female sterilizations were performed in the interval and post partum (the third cesarean section), applying laparoscopy or mini-laparotomy according to Pomeroy, in some cases the obsolete Madlener technique, while vasectomies were performed by using the standard method. The accurate statistical data on complications are not available but are estimated to be minimal. Requests for a tubal or seminal duct reconstruction have been exceptional. With a higher number of sterilizations the incidence of induced abortions in women at the age of more than 35 years would be reduced and the use of contraception would be increased. Yugoslavia, besides Albania and the Soviet Union, was the last to resort to contraceptives.

Female↗
PubMedDate not supplied

[The effect of induced abortion in adolescence on the manifestations of spontaneous abortion, premature labor and birth weight].

An experimental group of adolescents having become pregnant after induced abortion (n = 320) were compared with 514 primigravid adolescents, 391 women 20-24 years old having become pregnant after induced abortion, and 368 primigravid women of the same age. Spontaneous abortion appeared more frequently in the experimental group (5.9%) than in all control groups (5.1%, 3.3%, and 3.8% respectively. Preterm delivery was more frequent in the experimental group (9.3%) than in the control groups (6.8%, 6.4%, 5.7%, respectively). In the young adolescents (14-16 years old) of the experimental group, spontaneous abortion was almost twice as frequent (10.7%) as in the older adolescents of the same group (5.5%) and preterm delivery two and a half times as frequent (24.0%) as in the primigravid adolescents of the same age (10.3%). The weight of the newborns in the experimental group (3,155.7 +/- 536.3 g) was significantly lower than that in primigravid adolescents (3,228 +/- 488 g; t = 1.97, p less than 0.05), in women 20-24 years old with an earlier induced abortion (3,303 +/- 556 d; t = 3.49, p less than 0.01), and in primigravid women 20-24 years old (3.331 +/- 508; t = 4.30, p less than 0.001). The adolescents of the experimental group had on term deliveries in the 40th to the 42nd week significantly less frequently (31.6%) than primigravid adolescents (47.1%), 20-24 year-old women with earlier induced abortion (47.4%), and 20-24 year-old primigravid women (53.8%).

Abortion, Induced↗
PubMedDate not supplied

[The effect of artificial abortion on the course and result of subsequent pregnancy].

The study covered a total of 1,488 pregnant women who came for their first prenatal consultations in about the 19th week of pregnancy. The experimental group consisted of 416 women previous pregnancy ended with artificial abortion. In the control groups there were women who had neither a delivery nor abortion, then women whose previous pregnancy ended with the birth of a live child, and, finally, women in whom the previous pregnancy ended with spontaneous abortion. It has been shown that after artificial abortion, spontaneous abortion and premature deliveries in the subsequent pregnancy are just as frequent as in women who have not been pregnant (ili who had no delivery). Nor was there any higher percentage of low birth-weight children or perinatal mortality. A larger number of newborns weighing at birth less than 2,500 g was observed in women in whom abortion was performed by vacuum aspiration and not by curettage. In women with the abortion performed by vacuum aspiration and becoming pregnant in the first year following abortion, there was a significantly higher number of premature deliveries and low birth-weight children.

Abortion, Induced↗