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Biomedical subjects

L Alexander

Publications and source records attributed to L Alexander.

At least 91 records · Page 5Linked to original sources
PubMed1980

Epidemiology of acromegaly in the Newcastle region.

In an attempt to derive estimates of the incidence and prevalence of acromegaly a survey of the population in the area served by the former Newcastle Regional Hospital Board has been conducted to detect cases of acromegaly alive after 1 January 1960 and diagnosed before 31 December 1971. Cases were detected by means of letters to general practitioners, hospital physicians, neurosurgeons and to hospital records officers, as well as from death certificates. From the population of 3.1 millions a firm diagnosis of acromegaly was made in 164 patients, in eighty-one on clinical grounds alone and in eighty-three with confirmation by assay of human growth hormone (hGH). The annual incidence of acromegaly appears to be close to three cases per million and the prevalence of diagnosed cases up to forty cases per million. In male acromegalics there was a significant increase in the risk of death from cardiovascular, cerebrovascular respiratory and malignant diseases but in females from cerebrovascular disease only.

Acromegaly↗
PubMed1980

Suitability of vigilance test data as a neurobehavioral measure of uremic status.

A vigilance/continuous performance test was designed to be used for the serial testing of patients on chronic maintenance hemodialysis therapy. Correct detections, false alarms, and reaction time provided measures of an attentional deficit. A matched sample of 28 patients and 28 controls composed of nondialysands were tested. No significant differences were found between groups in correct detections and false alarms. Reaction time discriminated younger and older subjects and also dialysands and controls. The clinical usage of the test is questioned because patients resist taking the test on a serial basis every 2 wk. Motivational factors or lack of willingness to be compliant outweighed technical accomplishments.

Adolescent↗
PubMed1979

Unusual leiomyoblastoma of the stomach.

Only about 250 cases of benign gastric leiomyoblastoma of the stomach have been reported. Most occur in the smooth muscle of the antrum, and may be intramural, intraluminal, or exogastric in position. A pedunculated gastric leiomyoblastoma occurs less frequently, and those containing radiographically identifiable calcifications are extremely rare.

Aged↗
PubMed1979

Long-term survival in a case of stage IV carcinoma of the ovary treated with a single chemotherapeutic agent.

A case of stage IV carcinoma of the ovary is presented which was treated approximately six years ago in the Department of Radiation Therapy at Queens Hospital Center. On September 12, 1972, the patient had a total abdominal hysterectomy and bilateral salpingo-oophorectomy for a papillary scirrhous cystadenocarcinoma of the left ovary. At the time of the operation, the patient was found to have stage IV carcinoma of the ovary due to metastases of the liver and rectum. She was scheduled to receive pelvic-abdominal postoperative radiation therapy via the moving strip technique. Unfortunately, after completion of two strips, the patient could not tolerate treatment. She then began chemotherapy with a single agent, chlorambucil.Chlorambucil, 0.2 mg/kg/day×25 days/course was administered. The patient received 18 courses. Treatment dosage on a few occasions was decreased and increased again, due to drops in hemoglobin level and white blood cell and platelet counts. At the time of this presentation, the patient has no signs or symptoms of the disease. The introduction of megavoltage radiotherapy and adjuvant chemotherapy postoperatively has significantly improved the prognosis for patients with ovarian carcinoma. However, despite progress in radiotherapy, some patients cannot sustain this kind of treatment due to the unwanted side effects. Such was the case in this patient. She was switched to chemotherapy with excellent results in response and survival, even cure.

Adenocarcinoma, Scirrhous↗
PubMed1979

Total lung irradiation and chemotherapy in pulmonary metastases from carcinoma of the uterine cervix and endometrium.

Despite the radiocurability of stage I and II squamous cell carcinoma (SCC) of the cervix, palliation of patients with pulmonary metastases has been disappointing. Four patients with pulmonary metastases (three from cervical and one from endometrial carcinoma) were treated with total lung irradiation, followed two to three weeks after termination of radiotherapy with combination chemotherapy consisting of vincristine 1.4 mg/m(2) IV+ adriamycin 50 mg/m(2) IV + cyclophosphamide 500 mg/m(2) IV repeated at four-week intervals. Radiotherapy was delivered through a Co(60) teletherapy unit in a daily dosage of 100 rads in anterior and posterior opposing fields. After completion of irradiation in one lung, the other lung was similarly treated if involved with gross disease. Two out of four patients (both with cervix SCC) obtained complete tumor regression, whereas the other two patients had stabilization of their pulmonary lesions. The survival of the two responders was 216+ and 621 days from the start of irradiation. The two nonresponders survived 56 and 109 days. Except for one patient who died of pulmonary metastases, the remaining three patients died of metastases elsewhere. While only one patient developed radiation pneumonitis, all four had alopecia and leukopenia <4000/mm(3) from chemotherapy. Total lung irradiation and combination chemotherapy appear to have activity in the treatment of pulmonary metastases from SCC of the cervix and warrant further exploration.

Adult↗
PubMed1977

Pituitary problems.

Explore the source record for details and available documents.

Cushing Syndrome↗
PubMed1976

The double-bind theory and hemodialysis.

A review of the literature on the psychosocial problems attending hemodialysis provides no coherent theory or approach to explain the high incidence of psychiatric morbidity in this medical population. The literature is characterized in the main by the assumption that the problems lie either in the patients or in the stresses consequent to the treatment. Little recognition is given the fact that hemodialysis patients, unlike patients in other medical categories, are involved in intense, ongoing, and in many cases permanent, interpersonal relationships with medical professionals. Instead of looking at the personalities, predispositions, or capacities of patients, or how these responded to handicap and stress, the focus here is on the structure or pattern of the staff-patient relationships in this context.

Adult↗
PubMed1976

When to glaze--an electron microscope study.

1. A smooth porcelain surface can be obtained by glazing after grinding. There is no need for sanding or polishing with a rubber wheel. 2. A low-fusing glaze gives a slightly smoother surface than a natural glaze. The low-fusing glaze may be added at any stage of polishing, and the results will be the same.

Dental Porcelain↗
PubMed1975

A simple cell-suspension method for transplantation of V2 carcinoma.

A simple and rapid method for the preparation of an essentially monodispersed cell suspension from the rabbit V2 carcinoma, suitable for either large or small amounts of tumor tissue, did not require specialized equipment and yielded relatively large numbers of viable cells. Cell suspensions prepared by this method could be used to approximate a dose-response curve relating the percentage of tumor takes to the number of cells inoculated and could allow quantitative correlations not possible when macroscopic tumor fragments are used for implantation. The method, or slight modifications of it, should prove suitable for most tissues with a significant connective tissue component.

Animals↗