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Biomedical subjects

L Adolfsson

Publications and source records attributed to L Adolfsson.

29 records · Page 2Linked to original sources
PubMed1987

Catecholamine release after physical exercise. A new provocative test for early diagnosis of pheochromocytoma in multiple endocrine neoplasia type 2.

A simple and practical provocative test is needed for early asymptomatic pheochromocytoma, which is a major risk for patients with multiple endocrine neoplasia type 2 (MEN-2). We measured plasma catecholamines before and after submaximal exercise in 26 MEN-2 gene carriers, eight of whom with asymptomatic pheochromocytoma, nine with medullary thyroid carcinoma and 10 after uni- or bilateral adrenalectomy. Seventeen clinically healthy individuals and 11 patients with neurovegetative lability and symptoms mimicking pheochromocytoma served as controls. Plasma adrenaline, noradrenaline and dopamine increased after exercise except for adrenaline after bilateral adrenalectomy. The post-exercise levels of adrenaline and the adrenaline/dopamine ratio were significantly higher in the pheochromocytoma patients compared to the healthy controls and the patients with neurovegetative lability, while the patients with medullary thyroid carcinoma represented an intermediate group with a high probability of developing adrenal tumors. The present method is a physiological test with a high sensitivity and specificity. It is practical and well suited for repeated examinations and seems to be of value for the detection of early pheochromocytoma in MEN-2 patients. Furthermore, the test could be used in the differential diagnosis between pheochromocytoma and neurovegetative lability.

Adrenal Gland Neoplasms↗
PubMed1985

Reference values for exercise tests with continuous increase in load.

Reference values for exercise tests with continuous increase in load are presented. The exercise tests were performed on an electrically braked bicycle ergometer by 188 randomly selected Swedes of both sexes who were between 20 and 79 years of age. The reference values are related to sex, age (in decades) and weight and classified in decreasing levels of exercise capacity. Reference values for systolic blood pressure at different work loads are also given.

Adult↗
PubMed1985

Effect of metoprolol on "non-specific" ST-segment and T-wave changes.

Metoprolol, a cardio-selective beta-adrenergic blocking agent, was studied in 25 patients to assess its effect on "non-specific" ST-segment and T-wave changes both at rest and during exercise. In two thirds of the patients with ST-T-abnormalities at rest, the changes disappeared completely after beta-blockade but reappeared during exercise in some of them. Only in 9 patients were the changes eliminated also during exercise implying that they were "functional", i.e., caused by increased sympathetic discharge. In those patients, where the ST-T-abnormalities were not affected at all by the beta-blockade, they were probably due to organic heart disease, whereas when they were reduced but not completely abolished, increased sympathetic tone as well as organic heart disease might be the cause. It is inferred that the diagnostic information is increased by studying the effect of beta-blockade not only at rest but also during exercise. Metoprolol seems to be well suited for the evaluation of "non-specific" ST-T-abnormalities, especially when non-selective beta-blockers should be avoided, e.g. in obstructive lung disease.

Adolescent↗
PubMed1982

Diagnosis of deep vein thrombosis with 99Tcm-plasmin.

The diagnostic efficiency of 99Tcm-plasmin test was evaluated by X-ray contrast phlebography in 110 consecutive patients with suspected deep vein thrombosis (DVT). The test was positive in 50 of 55 patients with DVT (sensitivity 91%) and negative in 18 of 55 without DVT (specificity 33%). The positive plasmin test in patients without DVT was in most cases due to another inflammatory process or a post-thrombotic state. The 99Tcm-plasmin test is a rapid and sensitive screening method for th diagnosis of DVT, but as it is based on comparison between the legs, it may be unreliable in cases of bilateral thrombosis. The low specificity makes it less valuable in patients with concomitant inflammatory disease or previous thrombosis in either leg. When the plasmin test is positive, the diagnosis of DVT should in most cases be confirmed by X-ray contrast phlebography.

Adult↗
PubMed1976

Hemodynamic effects of two cardioselective beta-adrenoceptive antagonists, metoprolol and H 87/07, in coronary insufficiency.

Nineteen patients with ischemic heart disease were randomized into two groups and received either metoprolol or H 87/07. Heart catheterization was performed, and the groups were studied at rest and during exercise--before and after intravenous drug administration. During work metoprolol gave a statistically significant reduction in left ventricular work (expressed as pressure-rate product) of about 20%, mainly depending on a reduction in heart rate. Cardiac output decreased by 21%. Stroke volume was almost unchanged. The abnormal increase in left ventricular filling pressure during work was slightly, but not significantly, reduced by the drug. For H 87/07 no significant changes were found in the corresponding variables. This seems, however, to depend on an inadequate dosage, since not even the heart rate during work was significantly reduced. In conclusion, in the doses used metoprolol has been shown to be a potent beta-adrenoceptive antagonist in contrast to H 87/07.

Adrenergic beta-Antagonists↗
PubMed1969

Effects of a cardio-selective beta-adrenergic blocker (I.C.I. 50172) at exercise in angina pectoris.

A cardio-selective beta-adrenergic blocking agent (I.C.I. 50172), which has been studied both in normal subjects and in patients with angina pectoris during and after a standardized work test, produced a significant increase in the exercise tolerance of the patients. These favourable effects are comparable with those of propranolol.One patient with severe bronchial asthma and coronary insufficiency treated with I.C.I. 50172 improved and his respiratory function was not impaired.

Adult↗
PubMedDate not supplied

Arthroscopic removal of os centrale carpi causing wrist pain.

The os centrale carpi is a relatively rare accessory carpal bone of the wrist that infrequently has been reported to cause symptoms. This report describes 2 cases where an apparently mobile os centrale carpi caused painful clicking and crepitus and where the symptoms disappeared after arthroscopic removal of the ossicles.

Adolescent↗