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Biomedical subjects

L A Sobrevilla

Publications and source records attributed to L A Sobrevilla.

15 recordsLinked to original sources
PubMed1980

Effects of progestin-estrogen combination and progestational contraceptives on pituitary gonadotropins, gonadal steroids and sex hormone-binding globulin.

The effects of three kinds of hormonal contraceptives on the levels of follicle-stimulating (FSH), luteinizing hormone (LH), estradiol, progesterone, testosterone, and sex hormone-binding globulins (SHBG) in three groups of normally menstruating women were analyzed. During the administration of a very low-dose combination of 150 micrograms of D-norgestrel and 30 micrograms of ethinylestradiol, a progressive suppression of LH, FSH, estradiol, and (to a lesser extent) testosterone levels was observed while progesterone stayed at levels found during the early follicular phase. SHBG levels in these subjects were within the normal range for women. Oral treatment with 0.5 mg of lynestrenol and the intramuscular administration of 200 mg of norethindrone enanthate produced a suppression of LH but not FSH in all cases. Estradiol levels showed peaks in the three women treated with lynestrenol and in half of those treated with norethindrone enanthate, suggesting follicular activity caused by the unsuppressed FSH stimulus; the subsequent elevation of progesterone in two subjects suggested some luteinization, although there was no evidence of an ovulatory surge of gonadotropins. The SHBG in four subjects treated with norethindrone enanthate fell within our normal range for men, and the mean serum testosterone levels fell 40% below the normal basal levels in these cases.

Adult↗
PubMedDate not supplied

Postpartum and postabortion use of the TCu-220C and Lippes Loop: A comparative study.

The postinsertion experience of 274 women with the TCu-220C and 522 women with the Lippes Loop in a university hospital family planning program in Bogotá, Colombia, has been studied by a life-table method. Pregnancy and continuation rates are similar for both devices. Although the expulsion rate of the TCu-220C is significantly lower than that of the Loop up to 12 months, higher removal rates for the TCu-220C account for the similarity in overall continuation.

Abortion, Spontaneous↗
PubMedDate not supplied

[Urinary oestriol excretion and the lecithin/sphingomyelin ratio in amniotic fluid in Bogota (2600 m) I. Normal pregnancy (author's transl)].

We have studied 22 pregnancies in order to establish normal values for the urinary oestriol excretion in Bogotá, a city 2600 metres above sea level. The study subjects were normal pregnant women attending the prenatal clinic of the Hospital San José de Bogotá, and belong to a racially mixed community of medium to low socio-economic level. In the study, new born weight was found low (mean +/- SEM 2.97 +/-0.06 kg) while placental weight was high (0.6 +/- 0.02 kg) with a high placenta/newborn ratio. Maternal hemoglobin was elevated (12.8 +/- 0.2g/100 ml) reflecting the effect of altitude. In 66 determinations, oestriol excretion was more than 4mg/24 hours from week 31 to 36 and of more than 5 mg/24 hours from week 35 to 40. The decreased excretion of oestriol most likely reflects impaired intrauterine fetal growth, and is probably related to nutrional, racial and socio-economic factors as well as to the altitude. In five normal term pregnancies studied, the lecithin/sphingomyelin ratio was of 2 or more and amniotic fluid creatinine was also elevated, indicating maturity of the pulmonary and renal enzyme systems of the fetus.

Altitude↗