Search PubMed⌕ Search

Biomedical subjects

L A Ross

Publications and source records attributed to L A Ross.

60 records · Page 4Linked to original sources
PubMedDate not supplied

Computed tomography and magnetic resonance imaging of cavernous sinus enlargement in a dog with unilateral exophthalmos.

Computed tomography (CT), magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) were performed on a dog with a two year history of unilateral exophthalmos occurring two years following head trauma. On CT images, an expansile enhancing mass was present along the right intracranial cavernous sinus and extended through the orbital fissure into the retrobulbar space. With MRI, the structure appeared as a signal void due to the presence of rapidly flowing blood. Gadolinium enhancement of the adjacent brain was not present. A vascular origin of the lesion was confirmed with MRA. Based on the CT and MRI findings, the enlarged cavernous sinus and associated ophthalmic plexus were believed to represent an arterialized aneurysm, most likely the result of traumatic arteriovenous fistulization. Treatment consisted of surgical enucleation. At the time of this report, 29 months later, the dog remains free of clinical signs.

Animals↗
PubMedDate not supplied

Canine leptospirosis. A retrospective study of 17 cases.

Seventeen dogs were diagnosed with leptospirosis on the basis of clinical findings, laboratory abnormalities, and serology. This article summarizes and characterizes the historical and physical findings, laboratory data, serology, treatment, and outcome of these dogs. All of the dogs had serologic evidence of infection with interrogans serovars pomona and grippotyphosa. These findings are compared with previous reports of canine infection with Leptospira interrogans serovars icteroaemorrhagiae and canicola. The clinical presentation of these dogs did not correspond to the classic description of the disease in dogs in which concurrent renal and hepatic diseases are present. This may be due to infection with different serovars than those previously reported. In addition, this article suggests that canine leptospirosis should be considered in the differential diagnosis of dogs with acute or subacute renal failure.

Animals↗
PubMedDate not supplied

Disposition and metabolism of adriamycin octanoylhydrazone (NSC 233853) in mice and rabbits.

The disposition, metabolism, and excretion of adriamycin octanoylhydrazone (OctAdr) were studied after iv administration to BALB/c mice and New Zealand White rabbits and were compared to similar studies of adriamycin (Adr). In mice, concentrations of OctAdr-derived fluorescence were initially greatest in lung with very low concentrations detectable in kidney, liver, and spleen. Little drug fluorescence was found in brain, heart, or skeletal muscle. Adriamycin had the highest drug fluorescence concentration in the kidney, with progressively lower but easily detectable concentrations in liver, heart, lung, spleen, and skeletal muscle. Drug fluorescence was lost much more rapidly from tissues of mice injected with OctAdr than from tissues of mice injected with Adr. At all times after injection, Adr was the major fluorescent drug species recovered from livers and kidneys of mice treated with OctAdr or Adr, although substantial amounts of unaltered OctAdr were recovered from the former group. In rabbits, plasma concentrations of OctAdr-derived fluorescence declined rapidly but then remained relatively constant from 120 to 480 min after injection. No OctAdr-derived fluorescence was observed in urine. During the 8 hr after injection, biliary excretion of OctAdr represented approximately 25% of the administered dose. At all times after injection, OctAdr was the major biliary fluorescent species, with Adr and adriamycinol (Adrol) the second and third most prominent, respectively. Eight hours after OctAdr administration, lung contained the highest concentration of drug-related fluorescence, with progressively lower amounts in liver, kidney, duodenum, and heart. Brain, skeletal muscle, and spleen contained little or no OctAdr-derived fluorescence. Adr and OctAdr were the major fluorescent species in all tissues. Small amounts of Adrol were detected in all tissues, but aglycones were present only in liver.

Animals↗