Biomedical subjects
L A Rigberg
Publications and source records attributed to L A Rigberg.
Diverticulosis--diverticulitis: newer concepts and rare case presentation.
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Two rare causes of portal hypertension: the importance of establishing the cause.
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Rational role of upper gastrointestinal endoscopy.
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Continuous low dose peripheral vein pitressin infusion in the control of variceal bleeding.
Continuous low dose peripheral vein pitressin has been shown to be effective in controlling variceal bleeding in seven episodes of bleeding in six patients. No significant side-effects were seen. The expense, delay and hazard associated with superior mesenteric artery catheterization for selective arterial pitressin infusion were avoided. If these results can be reproduced, low dose peripheral vein pitressin infusion may prove to be a valuable addition to the treatment of bleeding esophageal varices.
Chlorpropamide-induced granulomas. A probable hypersensitivity reaction in liver and bone marrow.
Anicteric hepatitis, associated with fever and exfoliative dermatitis, developed in a diabetic patient two weeks after intake of a long-acting sulfonylurea, chlorpropamide (Diabinese). Granulomas showing heavy infiltration with eosinophils were found in the liver and bone marrow. These were interpreted as manifestations of an allergic reaction. The clinical signs, abnormal laboratory findings, and hepatic lesions subsided spontaneously on withdrawal of the drug. Bone marrow changes, however, persisted seven months after cessation of the drug. To our knowledge, this is the first report of a patient with liver and bone marrow inflammation characterized by granulomas with eosinophilic infiltration following intake of chlorpropamide.