The relation of pregnancy associated plasma protein A (PAPP-A) in the umbilical circulation of the human fetus to oestriol production by the placenta.
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Estriol↗
Biomedical subjects
L A Perry
Publications and source records attributed to L A Perry.
Placental protein 12 (PP12): a new test for the prediction of the small-for-gestational-age infant.
The circulating levels of placental protein 12 (PP12) and placental lactogen (hPL) were measured in 501 women between 36 and 41 weeks gestation. There was a significant positive association between hPL levels and infant birthweight and a significant negative association in the case of PP12 levels. The clinical efficiency of elevated PP12 levels in the prediction of low-birthweight infant at term compared favourably with that of reduced hPL levels.
Birth Weight↗
Use of parental advisors in the development of a parental coping scale.
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Adaptation, Psychological↗
Quantitative cytophotometric determination of DNA, RNA and lysine bound protein in relationship to zygote formation and protein synthesis in myxamoebae and swarm cells of Didymium iridis.
Quantitative cytochemical determinations were made of the DNA of zygotes formed from myxamoebae and swarm cells of Didymium iridis. The nuclear and cytoplasmic RNA and lysine bound protein of these cells were also measured. Significant zygote formation in myxamoebae crosses began at 20-30 min, while swarmers required 35-40 min. Myxamoebae, however, demonstrated a greater ability to form zygotes. The total cytoplasmic RNA and protein bound lysine for myxamoebae was higher than that of the swarmer cells. This observed decrease in swarmers may be due to reduced protein synthesis. Values for nuclear RNA were higher in the myxamoebae, but nuclear lysine bound protein was higher in the swarmers. The data presented suggest that prefusion swarmers, after replicating their DNA, go into a period of G2 arrest and remain in this condition postfusion. In contrast, prefusion myxamoebae readily divide after DNA replication, and continue to synthesize nuclear DNA, and to divide after fusion.
Crosses, Genetic↗
Polarization fluoroimmunoassay of 11-deoxycortisol in serum and saliva.
We developed polarization fluoroimmunoassays for 11-deoxycortisol in serum and saliva. To avoid interfering factors, the steroid was initially extracted from the biological fluids with dichloromethane. Assays could then be completed without any further separation procedures or need to correct for blank signals. The serum assay was suitable for following the response to the metyrapone test and results correlated acceptably with those by an established, specific, direct 125I-radioimmunoassay. The method is not sufficiently sensitive to detect 11-deoxycortisol in normal saliva, but greatly increased concentrations were found in post-metyrapone saliva and results agreed well with those by the radioimmunoassay as modified for salivary assay. Salivary 11-deoxycortisol assay would provide a convenient means of monitoring results of the metyrapone test.
17-Hydroxycorticosteroids↗
Radioimmunoassay of cortisol in saliva with the "GammaCoat" kit.
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Humans↗
A direct radioimmunoassay for 11-deoxycortisol.
A rapid, sensitive and highly specific radioimmunoassay (RIA) for 11-deoxycortisol has been developed and used for the measurement of serum concentrations. Antisera were raised using 11-deoxycortisol -3-carboxymethyloxime-bovine serum albumin as immunogen and showed minimal cross reaction with related steroids. 11-Deoxycortisol-3-carboxymethyloxime was coupled to 125 I-iodohistamine to produce a labelled antigen of high specific activity (s.a. 680 Ci/mmol). The assay was performed for 1h at room temperature and pH 4. Results were correlated with those after extraction, high pressure liquid chromatography and RIA of serum samples (y= 0.78x + 36.9; r = 0.97, p less than 0.001). The accuracy of the method was satisfactory (y = 1.00x - 0.61; r= 0.95; p less than 0.001). Assay sensitivity was 0.3 nmol/l. 11-Deoxycortisol concentrations in normal subjects at 09.OOh were 26-46 nmol/l (37.2 +/- 5.7; x- +/- 1 S.D.). The assay should facilitate the investigation of patients with possible abnormalities of adrenocortical function.
17-Hydroxycorticosteroids↗
Salivary cortisol determination: adaptation of a commercial serum cortisol kit.
The determination of cortisol levels in saliva offers a number of significant advantages as compared with plasma or serum measurements, and radioimmunoassay is the technique of choice because of the greater sensitivity required. To date, the assay of salivary cortisol has been limited to only a few centres employing 'in-house' reagents. We describe some simple modifications of a commercial kit, designed for the assay of cortisol in serum and urine, which allow direct and rapid determination of the steroid in saliva. These modifications enable any laboratory with access to a gamma counter to perform large numbers of salivary cortisol assays at relatively low cost.
Adult↗
What you should know about dental prepayment plans.
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Insurance, Dental↗
Effects of delivery on fetal unbound cortisol concentration.
Non-protein-bound (free) cortisol in plasma is that fraction of the total plasma cortisol concentration that is generally regarded as biologically active. The concentration of free cortisol in cord vein plasma obtained at delivery was found to be related closely to the total cortisol concentration. After vaginal delivery following spontaneous onset of labor the free cortisol concentration in cord blood was not significantly different from that measured following induced onset of labor. The free cortisol concentration in the cord blood correlated significantly with the duration of the second stage of labor. These changes in the free cortisol concentration in cord plasma, rather than constituting a primary event in the onset of labor, may reflect the stress of vaginal delivery on the fetus.
Cesarean Section↗
Comparisons of the concentrations of palmitate and cortisol in amniotic fluid for the prediction of pulmonary maturity.
The concentrations of palmitic acid, derived from lecithin, and of cortisol in samples of amniotic fluid collected during the last trimester of human pregnancy, ranged from 28 to 420 mumol/l and from 16 to 104 nmol/l, respectively. There was a weak (r = 0.43) but significant (p less than 0.01) correlation between the concentrations of cortisol and palmitate in the samples. Measurement of the cortisol concentration in amniotic fluid provided an unreliable index of pulmonary immaturity, whether this was assessed with reference to the concentration of palmitate or from subsequent development of the respiratory distress syndrome. Measurement of cortisol in amniotic fluid cannot be recommended for this purpose.
Amniotic Fluid↗
Plasma prolactin in pregnancy induced hypertension.
In a prospective study, plasma prolactin concentration at 37 to 41 weeks gestation in 45 primigravidae showed a significant correlation with maximal rise in diastolic blood pressure between levels at 7 to 16 weeks and those measured between 28 weeks and delivery.
Female↗
The relationship between selected educational outcomes of senior RN-to-BSN students and their choice of advanced placement options available in the Maryland nursing articulation model.
If national standards for entry into practice are to be changed, viable routes to achievement of the BSN must be established in each state. Maryland has implemented a statewide articulation model that allows the registered nurse to obtain credit for work completed at lower division schools through one of three advanced placement options. This study sought to answer the question of whether there is a difference in selected academic outcomes of senior RN-to-BSN students who choose different pathways available in the model. Data were collected from all students (n = 113) completing clinical concepts courses at a large university school of nursing. The independent variables were mode of entry and pattern of study. The dependent variables were scores obtained on the National League for Nursing (NLN) Comprehensive Nursing Achievement Test for Baccalaureate Nursing Students and the grades obtained in the spring and fall nine-credit clinical concepts courses (examinations, formal papers, clinical evaluations). The entry pathway did not make a significant difference in terms of scores on the spring NLN examination, course tests, or paper grades. However, differences were noted in the clinical area. Transition course students achieved the highest mean clinical performance score, and direct transfer students achieved the lowest score. The implication for nursing education is that there appears to be no significant difference in academic achievement of RN-to-BSN students admitted for advanced placement using three different validating procedures.
Adult↗
Adrenocortical adenoma--an unusual presentation with hypersecretion of oestradiol, androgens and cortisol.
We describe a 6 year-old boy who presented with bilateral gynaecomastia, pseudoprecocious puberty and facial features suggestive of Cushing's syndrome. The underlying pathology was a right adrenocortical adenoma which was secreting oestradiol, androgens and cortisol. All the biochemical abnormalities normalised within one week of right adrenalectomy. To our knowledge this combination of hormones produced by an adrenocortical adenoma is particularly unusual.
Adenoma↗
Self-reported adjustment, chronic sorrow, and coping of parents of children with Down syndrome.
Mothers and fathers of children with Down syndrome were surveyed on overall patterns of adjustment and on frequency of chronic sorrow and coping behaviors. Fathers overwhelmingly (83%) depicted their adjustment in terms of steady, gradual recovery, while the majority of mothers (68%) reported a peaks-and-valleys, periodic crises pattern; chi 2 = 8.64, p less than .01. Mothers also reported higher frequencies for chronic sorrow as well as for behaviors such as self-blame and expression of negative affect. Thus, mothers and fathers in the same family may experience distinct differences in adjustment and coping as parents of a handicapped child.
Adaptation, Psychological↗
The Bridge Program: an overview.
Challenging the health manpower requirements of a diverse population is the concomitant need to prepare nurses from underrepresented groups with leadership skills. As the graduate educated nursing population is not congruent with the numbers of minorities in the general population, it is urgent that the academic community address this problem. The Bridge Program is one answer to this concern by a large university system. The Bridge Program provides academic support, mentoring, program enrichment for baccalaureate students from underrepresented groups who possess the ability and desire to pursue advanced nursing study. The preparation includes each student producing a scholarly project developed in collaboration with a research faculty member. These teaching-learning activities are to facilitate minority nursing students' access to the rigors of graduate education.
Education, Nursing, Baccalaureate↗