[The effect of mineral waters of differing chemical composition on the regenerative processes in tissue during the postradiation period].
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Biomedical subjects
Publications and source records attributed to L A Nikulina.
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Based on a macro- and microscopic analysis of the material of 2 section cases and 29 biopsies of persons operated on for arachnoidal cysts two types of cysts were distinguished: 1) arachnoidal cysts that occurred as a result of isolated congenital pathology of the leptomeninx; 2) cysts representing a manifestation of the combined developmental abnormality of the CNS occurring in the form of arachnoidal cysts coupled with intracerebral ones and with pathology of the adjacent cortical parts in the form of gross impairment of its architectonics and developmental abnormality of cerebral vessels.
Rat experiments have shown that course intake (21 days) of sulphate sodium-magnesium-calcium water with sulphate concentration 2.6 mg/l and mineralization 3.1 g/l in early postradiation period (1-2 Gy) inhibits development of dystrophic and destructive processes in spermatogenic epithelium of the testes and maintains spermatogenesis at higher level than control.
Drinking sulphate mineral water and that with addition of silicon prevented and restricted postradiation lesions in the spermatogenic epithelium of rat testis. Iodine-containing mineral waters had no protective effect on spermatogenesis.
Early after irradiation (2 Gy) white male rats were given sulfate mineral water, sulfate mineral water with silicon, iodine-containing mineral water (iodine concentration 30 mg/l). It was found that sulfate mineral water alone or with silicon reduces the number of endocrine Leidig's cells, inhibits their functional activity, lowers blood level of testosterone. These effects were not observed after intake of iodine-containing mineral water.
Histological and electron-microscopic studies of a radioprotective action of drinking sulphate mineral water (SMW) on spermatogenesis of irradiated male rats' progeny have found that SMW used before radiation (2 Gy) and 10 days after it is able to reduce postradiation sequelae in the progeny (2-5 month and 1.5 year old rats) testes.
Experiments on non-inbred male rats have found that pretreatment with drinking sulfate mineral water and veteron reduced incidence of radiation-induced aneuplodia in bone marrow cells. The proportion of cells with normal number of chromosomes went up.
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Experiments on male rats have established that preventive use of low-intensive impulse laser radiation (200-400 Hz) on the adrenals prevented and limited development of postradiation disorders of spermatogenesis in irradiated male rats and their progeny.
Drinking sulfate mineral water in combination with low-intensive infra-red laser or magneto-laser radiation is shown to effectively depress development of different forms of pathological mitoses in spermatogones of irradiated rats and in their first-generation progeny.
Assessment of thyroid function and antitoxic protein-synthesizing function of hepatocytes at light microscopic and ultrastructural levels revealed differences in the effects of natural and prepared iodine water under similar iodine-ion concentration (14 mg/l). The varieties seem to result from the presence of ion-salt base in the natural water.
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The article describes five cases of rare cerebral tumors, paragangliomas of the chiasma-sellar area. Their clinical course characteristically begins with the appearance of endocrine disorders manifested by progressive hypophyseal insufficiency. Analysis of the clinical and X-ray signs of paragangliomas of the chiasma-sellar region show these to be similar to adenomas of the hypophysis. A specific feature of paragangliomas of the chiasma-sellar area is their rich vascularization, which is demonstrated by angiography and verified in all cases during operation. The rich vascularization of paragangliomas of the chiasma-sellar area calls for their rapid and complete removal so as to reduce the loss of blood and provide reliable hemostasis.
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In experiments on 54 white noninbred male rats it was shown that drinking mineral water containing sulphate, calcium and sodium ions (Moskovskaia mineral water) activates postradiation regenerative processes in the thymus and the liver and normalizes functional activity of CCS-system in blood plasma if it was taken 28 days after whole-body 1 Gy gamma-radiation. This positive effect was less marked after 5 Gy gamma-radiation. Silicon and boron containing mineral water under the above conditions proved less effective.