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L A Lewis

Publications and source records attributed to L A Lewis.

At least 73 records · Page 4Linked to original sources
PubMed1989

Lack of recognition of internal medicine as a specialty: a factor in medical student career choice?

Interest among medical students in a career in internal medicine has recently declined. We propose that lack of recognition of general internal medicine as a specialty may be one factor in students' decisions to enter other fields. A survey of 300 first-year and second-year medical students at the Medical College of Georgia showed that 84% of the respondents plan to specialize, yet only 49% recognized general internal medicine as a specialty. Significantly higher percentages of students correctly classified six other specialties. Only family practice was less likely than internal medicine to be recognized as a specialty. Earlier recognition of general internal medicine as a specialty among students who want to specialize might result in an increased number of students entering internal medicine residency programs.

Awareness↗
PubMed1985

Curriculum change in the 1980s. A report of 40 southern US medical schools.

Forty southern medical schools were surveyed to evaluate the nature and mechanisms of curricular change during 1980 to 1983. Ninety percent of schools experienced change in some aspect of curriculum. Faculty, curriculum committees, the dean, and external forces were stimuli for change. Internal self-review or self-criticism seemed to be the most important reasons for change. Proposals were considered by curriculum committees and the dean, but veto power often rested with the dean, although departmental chairmen and faculty occasionally had veto power. Types of change were divided equally between content, timing of courses, and the educational process. Half the schools stated that they had evaluated the changes or planned to do so. Thirteen of 38 changes in curriculum were in the direction of curricular innovations of the 1960s and 1970s and 25 were in the opposite direction.

Curriculum↗
PubMed1985

A foreign medical school transfer program: student performance and career choices.

U.S. medical students who have been unable to gain acceptance into medical schools have long sought alternative pathways into American medical practice. The Medical College of Georgia (MCG) has had a transfer program since 1977 to facilitate entry of Georgia Transfer students into the third-year clinical rotations. After completing a remedial program of three to five months, transfer students have entered the third year and performed similarly to regular MCG students. Evaluation of 31 students who have graduated and for whom data are available shows no significant difference in performance when compared to other MCG students in terms of clinical grade point averages and NBME Part 2 scores. These students were also similar to their MCG peers in the number entering residencies within the state.

Career Choice↗
PubMed1984

Chromatographic behavior of immunoglobulin-bound creatine kinase on DEAE-Sephadex A-50.

We investigated the chromatographic behavior of CK isoenzymes and immunoglobulin-bound macro-CK by discontinuous gradient elution from DEAE-Sephadex A-50 at pH 7 and 8. In four of five patients with macro-CK, the macro-CK was eluted with the MB buffer at pH 8, but a significant portion of the complex was eluted with the MM buffer at pH 7, in a region between CK-MM and CK-MB. In the fifth patient, the macro-CK was eluted with the MB buffer at both pH values. The immunoglobulin patterns of all five patients and of normal serum showed that IgG and IgM are eluted mainly with the MM and MB buffers, respectively, at both pH values, whereas IgA is eluted mainly with the MB buffer at pH 8, but at pH 7, shows a significant shift similar to that of macro-CK. These characteristic patterns allowed the identification of the immunoglobulin in macro-CK as IgA in the first four patients, and as IgM in the fifth patient.

Adult↗
PubMed1984

Separation of CK isoenzymes on DEAE-sephadex A-50 at neutral pH.

The MM, MB and BB isoenzymes of human creatine kinase (CK) were separated by elution from micro-columns of DEAE-Sephadex A-50 with Tris buffer containing increasing concentrations of NaCl at pH 7.0, instead of pH 8.0 as has commonly been used. Since pH 7.0 is close to the pH optimum of CK, this allowed the use of four times larger aliquots of the eluates for the estimation of CK activity and, consequently, a 4-fold increase in sensitivity. Using serum specimens from patients with acute myocardial infarction, there was a good correlation of the CK-MM (r = 0.99) and CK-MB (r = 0.93) activities obtained with the two buffer systems. Similarly, normal sera had CK-MB and CK-BB activities of less than 2 U/l with both buffer systems. Comparison of the composition of serum proteins in the eluates by conventional electrophoresis revealed that although the distribution of CK isoenzymes separated by the two buffer systems was similar, the distribution of proteins at pH 7.0 showed an appreciable shift of protein from the MB to the MM eluates.

Blood Protein Electrophoresis↗
PubMed1984

Automated kinetic assay for lactate dehydrogenase isoenzyme 1 by centrifugal analysis after alkaline inactivation.

Lactate dehydrogenase isoenzyme 1 (LD1, EC 1.1.1.27) has been used widely as a marker for myocardial infarction, and many analytical methods for it have been developed, most of which are relatively labor intensive. On the basis of a recent report by Takizawa et al. (Clin Chem 29: 1941-1945, 1983) describing the marked stability of LD1 in buffered alkaline solutions, and with use of a centrifugal analyzer, we have developed a fully automated assay for LD1. Results with this method are precise (between-day SD = 2.1 U/L), vary linearly with LD1 activity to 600 U/L, and correlate well with LD1 as determined by immunological (Roche Isomune-LD) and agarose electrophoretic methods (r = 0.985 and 0.986, respectively). Furthermore, the method is easy and convenient, and should provide a substantial savings in labor and reagent costs to laboratories currently determining LD1 by electrophoretic or immunologic methods.

Autoanalysis↗
PubMed1982

The temporal response of recombination events to gamma radiation of meiotic cells in Sordaria brevicollis.

The temporal frequencies of different stages of prophase I were determined cytologically in Sordaria brevicollis (Olive and Fantini) as the basis for ascertaining the degree of synchrony in meiosis in this ascomycete. Croziers, karyogamy-zygotene and pachytene asci were shown to be in significant majorities at three distinct periods of the meiotic cycle. The response of recombination frequency to ionizing radiation was examined for the entire meiotic cycle. Three radiosensitive periods were determined. This response, which correlated temporally with each of the three peaks in ascal frequency, is interpreted as showing that the meiotic cycle of this organism is divided into periods of recombination commitment (radiation reduced frequencies) during the pre-meiotic S phase and recombination consummation (radiation induced frequencies) during zygotene and pachytene. The results are discussed in the context of the time at which recombination is consummated in eukaryotes such as yeast and Drosophila.

Ascomycota↗
PubMed1981

Description of the interview process in selecting students for admission to U.S. medical schools.

A survey was made of the medical schools in the United States to obtain a description of the interview process used in the selection of first-year medical students. The following questions were the basis for the study: What is the role of the interview in the selection of medical students? What is the nature of the interview process? How is the interview administered? An 87 percent response rate was obtained. The results indicated that 99 percent of the responding medical schools use interviews in evaluating students for medical school admission, and the interview ranks second only to the grade-point average in importance among four selection factors. The interview is usually in a one to one setting, with each applicant having two separate interviews. All schools use faculty and staff members in interviewing, and usually at least one admissions committee member interviews each applicant. Usually interviews are conducted on the campus of the school. Implications drawn from the results indicate a need for a quantification of methods to incorporate the interview into the selection process.

College Admission Test↗
PubMed1980

Significance alone is not enough.

Information and data vital for evaluating and/or replicating research are often absent from publications. Thirty-three research articles with findings based on results of t tests, F tests, or Pearson product-moment correlations were randomly selected from the Journal of Medical Education and examined for adequate research reporting. Effect size and power were found and analyzed when sufficient data were available. Nearly one-half of the studies did not report a sufficient amount of data; or, if satisfactorily reported, a number of statistical tests were found to have low power values. The importance of effect size and power in research is presented along with guidelines for adequate research reporting.

Evaluation Studies as Topic↗
PubMed1980

Drug-induced dyslipoproteinemia: a report of two cases.

We describe two cases of atypical dyslipoproteinemia due to drug-induction. This secondary form of lipoprotein abnormality is unique because the newly available drug, miconazole, apparently directly delipidated the alpha-lipoproteins in the bloodstream. On closer study we found that the delipidation was caused by the vehicle rather than the fungicide--more specifically, only by the polyethoxylated castor oil in the vehicle. It affects serum lipoproteins both in vitro and in vivo, and the effect is species-specific. In vitro studies indicate that it preferentially delipidates high-density lipoprotein rather than low-density lipoprotein. Because its effects on the serum lipoproteins of rats resemble those on man, and because aortic lesions were produced in rats injected daily (90 mL/L) with this substance, caution is indicated in long-term use of drugs containing this chemical component in the vehicle.

Adult↗