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Biomedical subjects

L A Jacobs

Publications and source records attributed to L A Jacobs.

At least 55 records · Page 3Linked to original sources

Patient-controlled analgesia versus intermittent analgesia dosing.

Actively involving the patient in his or her own pain management by using patient-controlled analgesia (PCA) during the postoperative period is a concept recently introduced. This method allows self-administration of small, frequent doses of an analgesic agent to maintain a state of constant pain control. We studied the relative efficacy of PCA compared with intermittent analgesic dosing in 16 male patients requiring posterolateral thoracotomy. Eight patients received intermittent doses of buprenorphine hydrochloride (0.3 mg intramuscularly every 3 to 6 hours), and eight patients were allowed to self-activate a PCA device according to a designed protocol. In the patients using PCA, a significant reduction in the postoperative pulmonary complication rate, as evidenced by radiographic findings, was noted. In addition, significantly less medication was used and postoperative fever was substantially reduced in the PCA group. We believe PCA to be a safe, effective, and beneficial pain management modality that deserves attention in the postoperative period.

Aged↗

Splanchnic and total body oxygen consumption differences in septic and injured patients.

The splanchnic and total body oxygen exchange and flow dynamics for injured patients (n = 7) and patients with sepsis and stable vital signs (n = 12) were studied. All patients were judged to be in the hyperdynamic phase of the stress response. In both patient groups 27% to 28% of the cardiac index was directed to the splanchnic circulation. However, in sepsis the splanchnic region consumed a significantly larger fraction (p less than 0.05) of the total body oxygen (43.8%) compared with that consumed in injury (30.2%). After injury, the regional splanchnic flow and oxygen consumption appeared to be well matched whereas in sepsis, a disproportionately higher oxygen consumption is found, which must be supplied by increasing blood oxygen extraction. This regional hypermetabolism of the splanchnic area probably results from the increased metabolic demand imposed by the various synthetic processes of this region. In addition, it is proposed that excessive discrepancy between splanchnic flow and oxygen demand may precipitate regional ischemia.

Aged↗

Common iliac to femoral bypass. An alternative in the high risk patient.

Eighteen patients presenting with atherosclerotic iliac occlusive disease have been treated with ileofemoral bypass grafting over the preceding 66 months. All patients were treated for limb salvage. The risk factors of this patient population were judged to be excessive for the performance of aortofemoral bypass grafting. The accumulated patency for this approach at 5 years was 84.6 per cent with a mean follow-up duration of 29.1 months. Based on these results, this approach appears to be an excellent inflow procedure for patients considered unsuitable for conventional aortofemoral reconstruction.

Aged↗

The relationship of insulin production to glucose metabolism in severe sepsis.

Basal glucose metabolism was evaluated in eight stable, infected patients by measuring hepatic glucose production rates in relation to stress endocrine profile and by comparing these data to five injured, noninfected patients. All patients exhibited normal total-body oxygen consumptions and cardiac indices. Fasting basal insulin values were similar in both groups (6 microU/cc) despite a significantly higher plasma glucose level in septic patients (106 +/- 14 mg/dL) compared to nonseptic patients (88 +/- 10 mg/dL). Septic patients exhibited splanchnic glucose production and calculated glucose clearance rates, 53% and 34% higher, than injured nonseptic patients, respectively. In addition, septic patients exhibited a decreased pancreatic insulin secretory response to an intravenous glucose tolerance test as evidenced by a significantly depressed peak insulin value (17 microU/cc) relative to injured patients (77 microU/cc). These findings indicate that insulin suppression is evident in sepsis even in the absence of shock and suggest that sepsis-related basal hyperglycemia does not appear to be associated with peripheral insulin resistance.

Aged↗

Cardiac tamponade due to an iatrogenic pericardial-diaphragmatic hernia.

Because of its ease, safety, and effectiveness, surgeons are increasingly using the subxiphoid approach to drain pericardial effusions and to insert epicardial pacemakers. Although we could find no previous reports of iatrogenic pericardial-diaphragmatic hernias in the literature, experience with a recent patient who developed this problem after a subxiphoid pericardial drainage suggests that it may become much more frequent. Physicians should strongly suspect this complication in patients with a triad of previous subxiphoid pericardial incision and signs of bowel obstruction and tamponade.

Aged↗

An assessment of the variability of early scalp-components of the somatosensory evoked response in uncomplicated, unshunted carotid endarterectomy.

Although many publications deal with the usefulness of the SER in CEAs, the criteria of calling a SER abnormal during a CEA are largely arbitrary. One way to define the limits of normalcy for SERs during the CEA will be to analyze the SER tracings obtained during unshunted and uncomplicated (intra- and postoperative) CEAs. In 23 such CEAs (10 right, 13 left; clamptime 10-23 mins.), data analysis at the ipsilateral parietal electrode, on stimulation of the contralateral median nerve (square pulse -5.1/sec, 10-30 V, 200 microseconds; bandpass-30-3000 Hz trials-500 stimuli), revealed that (1) latency fluctuations of the N20 (21.4 msec) were narrowest, being less than 1.5 msec different during and after clamping compared to the preclamp latency in all 23 CEAs, whereas those of P25 (27.4 msec) and N35 (38.5 msec) were greater than 2.0 msec different from the preclamp latency in 3 and 8 CEAs respectively, and (2) the amplitudes of N20, P25 and N35 measured from the preceding peak of opposite polarity, fell to less than 75% of the preclamp value on 3, 4 and 7 CEAs respectively. It is concluded that N20 was the most stable of the first three short-latency components in the SER and should perhaps be most relied upon to predict abnormality of the SER during CEAs.

Brain Ischemia↗

Management of aortofemoral graft failure.

A simplified technique of patch angioplasty is demonstrated for the reconstruction of the failed distal aortofemoral anastomosis. The salient features of this technique include performance of the angioplasty without disconnecting the original anastomosis and reutilization of the existing suture line in order to avoid late formation of a pseudoaneurysm.

Blood Vessel Prosthesis↗

The significance of hypoalbuminemia following injury and infection.

Serum albumin and absolute hepatic albumin synthetic rates were measured in ten seriously ill injured and septic patients using the (14C) carbonate technique. Although it is commonly believed that serum albumin levels (SAL) reflect hepatic function and visceral protein status in hospitalized patients, no relationship was found between these two measured parameters in this patient population. A depressed mean serum albumin level of 1.98 +/- 0.50 gm/dl (range: 1.25-2.69 gm/dl) was associated with a supranormal mean albumin synthetic rate of 215 +/- 121 mg/kg/day (range: 21-447 mg/kg/d). No significant mean SAL and albumin synthetic rate differences were noted between injured nonseptic and septic patient populations. Since albumin synthesis was elevated in most of these stressed patients these findings support the view that extravascular protein redistribution and/or increased peripheral catabolism are the major factors responsible for hypoalbuminemia in critically ill patients.

Aged↗

Infected venous pseudoaneurysm. A complication of drug addiction.

There has been an increase in the incidence of major vascular complications of intravenous drug addiction. We studied five patients who had infected venous pseudoaneurysms of the femoral vein. Patients may have cryptic sepsis or an infected hematoma from venous rupture. The vein containing pus may drain through a venipuncture site. Treatment is complete excision of the involved vein with packing of the wound. Complications due to septic embolization or metastatic infection from septicemia are common. Venous reconstruction is unwarranted.

Adult↗

Elective carotid resection for squamous cell carcinoma of the head and neck.

Patients with squamous cell carcinoma adherent to the carotid artery have a very poor prognosis, but some can be salvaged by aggressive surgical resection. Preoperative four vessel arteriography with intracranial views is mandatory to detect coexisting arteriosclerotic disease which may limit collateral perfusion of the ipsilateral cerebral hemisphere. Matas-type occlusive tests performed preoperatively are potentially dangerous and do not provide quantitative information that can be obtained intraoperatively by measuring internal carotid artery stump pressures. If the stump pressure is 50 mm Hg or greater, carotid reconstruction is unnecessary. A stump pressure of less than 50 mm Hg is an indication for reconstruction if the pharynx has not been entered during resection. If mucosal entry will be necessary and the stump pressure is less than 50 mm Hg, resection should not be carried out because of the increased risk of graft complications. Somatosensory evoked potentials predict cerebral tolerance to temporary interruption of flow but do not necessarily predict tolerance to permanent interruption of flow. Autogenous vein is the graft material of choice for reconstruction. In those patients not reconstructed, low-dose heparinization started before operation and continued for 10 days may lessen the likelihood of delayed stroke from embolization of a propagated thrombus in the carotid stump.

Adult↗

Neuropsychological impairment after carotid endarterectomy correlates with intraoperative ischemia.

Detailed neuropsychological assessments were performed before and shortly after carotid endarterectomy in thirty-four patients. The degree of intraoperative ischemia was assessed by monitoring the somatosensory evoked cortical potential change upon carotid clamping. Changed neuropsychological performance was found to be related to intraoperative ischemia most clearly in patients with a history of previous stroke and in those with more severe vascular disease. In such patients greater SSEP change was correlated with greater neuropsychological change postoperatively.

Aged↗

Iatrogenic hiatal and diaphragmatic hernias.

Seven patients with hernias occurring after Belsey hiatal hernia repair are described. These hernias were of two types. Four occurred through the hiatus, had the appearance of a parahiatal hernia, and were attributed to the failure to correct a shortened esophagus. In three patients the hernia occurred through a disrupted counterincision in the diaphragm. In the second group postoperative abdominal distension and possibly technical faults were incriminated. In the first group satisfactory repair was achieved by a Collis-Belsey gastroplasty and an antireflux procedure. In the second group reduction of the hernia and resuture of the diaphragm incision encompassing all layers corrected these life threatening hernias.

Female↗

Outcome after peritoneo-jugular shunting of pancreatic ascites.

Three patients with pancreatic ascites documented by ascitic fluid protein greater than 2.5 g/dl and elevated amylase in their peritoneal fluid were treated by peritoneo-jugular shunting (PJS). Patient 1 was so treated inadvertently; Patient 2 had resolving amylase levels but increasing amounts of ascites; Patient 3 had clear, active pancreatic ascites. None incurred untoward effects from this procedure. Ventilatory compromise from reduced diaphragmatic excursion was ameliorated in all patients. Two patients required no further therapy. The third patient was greatly improved in preparation for definitive surgical therapy for a leaking pancreatic pseudocyst. The infusion of enzyme-rich fluids into the circulation may be responsible for certain systemic effects of pancreatitis. Coagulation defects are a known complication of PJS for the ascites of Laennec's cirrhosis. There was no evidence of histamine-mediated cardiovascular collapse, exacerbation of respiratory failure, or coagulation defects in these patients. We conclude that these complications are not the inevitable results of PJS of pancreatic ascites.

Adult↗

Cognitive improvement after extracranial reconstruction for the low flow--endangered brain.

Twelve patients with multiple occlusive neck vessel lesions were thought to possess low flow-endangered brains. These patients were studied before and after carotid reconstruction with a battery of neuropsychologic tests emphasizing memory and mental agility. A closely matched control group was selected from patients undergoing endarterectomy for hemodynamically insignificant lesions. The patients with low flow-endangered brains showed significantly greater improvements in memory and mental abilities than did the control group. Reconstruction of neck vessels may reverse such global neurologic deficits in carefully selected patients.

Analysis of Variance↗

Cardiovascular performance and myocardial infarction following aortic surgery.

A review of all patients who had undergone aortic reconstruction for aortoiliac occlusive disease and aneurysm over the previous five years demonstrated that fatal myocardial infarctions occurred most frequently two or three days remote from surgery. The most outstanding hemodynamic finding was sustained tachycardia which displayed a maximum risk on the second postoperative day. The peak coincided with the period of maximum incidence of fatal myocardial infarction. We suggest that the degree of postoperative tachycardia, which is a major determinant of myocardial oxygen consumption, contributes significantly to the risk of acute myocardial ischemia.

Acidosis↗