Biomedical subjects

L A Drake

Publications and source records attributed to L A Drake.

57 records · Page 4Linked to original sources

PubMed1985

Cyclic nucleotides in muscarinic regulation of DNA and RNA polymerase activity in cultured corneal epithelial cells of the rabbit.

DNA and RNA polymerase activities in the purified nuclear fraction from cultured rabbit corneal epithelial cells were assayed over a range of substrate (labeled dTTP or UTP) concentrations using calf thymus DNA as template. Effects of carbamylcholine on polymerase activities were evaluated over a range of drug concentrations including those saturating muscarinic receptors. Carbamylcholine significantly (p less than 0.001) enhanced activity of both polymerases, both in nuclei incubated with the drug during assay and in nuclei from carbamylcholine-treated cells. Drug effects were blocked by atropine. Regression analysis of Hill plots for variation of polymerase activity with carbamylcholine concentration indicated half-maximal activity of both polymerases at approximately 1 microM carbamylcholine. Mechanisms by which carbamylcholine may alter polymerase activities are discussed in relation to effects of the drug on nuclear enzymes of cyclic nucleotide metabolism and on cyclic nucleotide-dependent protein phosphorylation.

Animals↗

PubMed1985

Dermatologic formulary.

The formulary for dermatologic use in the emergency department must not only encompass drugs that are essential for advanced cardiac and trauma life support, but must have specific drugs that are indicated for common dermatologic conditions that are evaluated in the emergency department. First and foremost is the selection of the appropriate drug for the disease. Other factors, such as the vehicle in which the drug is compounded, become equally important, as this directly affects the delivery of medication to the patient. Although this formulary is by no means complete, it is a reasonable guide for emergency medicine physicians to utilize when comtemplating dermatologic care. It is important when selecting a drug for dermatologic care that the physician be cognizant of the patient--the type, location, and condition of the skin--and of the disease he or she is treating. When these factors are given due consideration, the appropriate drug for the disease will be utilized for the ultimate benefit of the patient.

Anti-Infective Agents, Local↗

PubMed1985

Dyskeratosis congenita in a girl simulating chronic graft-vs-host disease.

Dyskeratosis congenita (DCG) is a rare genodermatosis characterized primarily by reticular hyperpigmentation of the skin, dystrophy of the nails, and leukoplakia. It is frequently associated with Fanconi-type pancytopenia. Although DCG has a male predisposition, it has been reported in several female patients. We encountered a case of DCG occurring in a girl whose clinical features simulated chronic graft-vs-host disease (GVHD). Because DCG and chronic GVHD share several clinical and histologic features, physicians should always examine a patient for possible DCG whenever a diagnosis of chronic GVHD is considered. In addition, the similar manifestations of the two disorders suggest a similar pathogenesis on a cellular level in the immunologic system.

Adolescent↗